Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5620-5624

  McClellan, William J ^a   Dai, Yujia ^a   Abad Zapatero, Cele ^a   Albert, Daniel H ^a   Bouska, Jennifer J ^a   Glaser, Keith B ^a   Magoc, Terry J ^a   Marcotte, Patrick A ^a   Osterling, Donald J ^a   Stewart, Kent D ^a   Davidsen, Steven K ^a   Michaelides, Michael R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Anti cancer; Aurora kinase; Orally bioavailable; Thienopyrimidine

Indexed keywords

AURORA KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051928516     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.041     Document Type: Article

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