HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1

Biochemical Journal

Volumn 401, Issue 1, 2007, Pages 247-256

  Mukherji, Atish ^a   Janbandhu, Vaibhao C ^a   Kumar, Vijay ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Cell cycle; Cyclin E; Cyclin dependent kinase 2 (cdk2); p27Kip1; Src kinase; X protein of hepatitis B virus (HBx)

Indexed keywords

ACTIVATION ENERGY; BINDING ENERGY; CELL CULTURE; ENZYME INHIBITION; VIRUSES;

CELL CYCLE; CYCLIN-DEPENDENT KINASE 2 (CDK2); SRC KINASE; X PROTEIN OF HEPATITIS B VIRUS (HBX);

PROTEINS;

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; HEPATITIS B VIRUS X PROTEIN; PROTEIN TYROSINE KINASE;

ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; DNA PRIMERS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIVER NEOPLASMS; PHOSPHORYLATION; RECOMBINANT PROTEINS; RETICULOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; VIRAL REGULATORY PROTEINS;

HEPATITIS B VIRUS;

EID: 33846333916     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061091     Document Type: Article

References (51)

1. Swanton, C. and Jones, N. (2001) Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products. Int. J. Exp. Pathol. 82, 3-13
2. Schang, L. M. (2003) The cell cycle, cyclin-dependent kinases and viral infections: new horizons and unexpected connections. Progr. Cell Cycle Res. 5, 103-124
3. O'Brien, V. (1998) Viruses and apoptosis. J. Gen. Virol. 79, 1833-1845
4. Everett, E. and McFadden, G. (1999) Apoptosis: an innate immune response to virus infection. Trends Microbiol. 7, 160-165
5. Butel, J. S. (2000) Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. Carcinogenesis 21, 405-426
6. Feitelson, M. A., Pan, J. and Lian, Z. (2004) Early molecular and genetic determinants of primary liver malignancy. Surg. Clin. North Am. 84, 339-354
7. Ganem, D. and Prince, A. M. (2004) Hepatitis B virus infection - natural history and clinical consequences. N. Engl. J. Med. 350, 1118-1129
8. Kumar, V. and Sarkar, D. P. (2004) Hepatitis B virus X protein: structure-function relationships and role in viral pathogenesis. In Handbook of Experimental Pharmacology (Triezenberg, S. J., Kaufman, J. and Gossen, M., eds.), pp. 377-407, Springer-Verlag, Berlin
9. Zhang, X., Zhang, H. and Ye, L. (2006) Effects of hepatitis B virus X protein on the development of liver cancer. J. Lab. Clin. Med. 147, 58-66
10. Bouchard, M. J. and Schneider, R. J. (2004) The enigmatic X gene of hepatitis B virus. J. Virol. 78, 12725-12734
11. Kim, H., Lee, H. and Yun, Y. (1998) X-gene product of hepatitis B virus induces apoptosis in liver cells. J. Biol. Chem. 273, 381-385
12. Arbuthnot, P., Capovilla, A. and Kew, M. (2000) Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways. J. Gastroenterol. Hepatol. 15, 357-368
13. Lee, Y. I., Kang-Park, S., Do, S. I. and Lee, Y. I. (2001) The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 276, 16969-16977
14. Lee, S., Tarn, C., Wang, W. H., Chen, S., Hullinder, R. L. and Andrisani, O. M. (2002) Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines. J. Biol. Chem. 277, 8730-8740
15. Benn, J. and Schneider, R. J. (1995) Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc. Natl. Acad. Sci. U.S.A. 92, 11215-11219
16. Bouchard, M., Giannakopoulosm, S., Wang, E. H., Tanese, N. and Schneider, R. J. (2001) Hepatitis B virus HBx protein activation of cyclin A - cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway. J. Virol. 75, 4247-4257
17. Sherr, C. J. and Roberts, J. M. (2004) Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18, 2699-2711
18. Murray, A. W. (2004) Recycling the cell cycle: cyclins revisited. Cell 116, 221-234
19. Kumar, V., Jayasuryan, N. and Kumar, R. (1996) A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. Proc. Natl. Acad. Sci. U.S.A. 93, 5647-5652
20. Kumar, V., Jayasuryan, N., Reddi, H., Sahal, D. and Panda, S. K. (1998) A monoclonal antibody against the X protein of hepatitis B virus: fine mapping of its epitope and application in a quantitative ELISA of the X protein in sera of hepatitis B patients. Hybridoma 17, 157-164
21. Hung, L. and Kumar, V. (2004) Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs. FEBS Lett. 560, 210-214
22. Watanabe, S., Itoh, T. and Arai, K. (1996) JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells J. Biol. Chem. 271, 12681-12686
23. Wolf, D., Witte, V., Laffert, B., Blume, K., Stromer, E., Trapp, S., D'Aloja, P., Schurmann, A. and Baur, A. S. (2001) HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat. Med. 7, 1217-1224
24. van den Heuvel, S. and Harlow, E. (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-2054
25. Rodier, G., Montagnoli, A., Di Marcotullio, L., Coulombe, P., Draetta, G. F., Pagano, M. and Meloche, S. (2001) p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 20, 6672-6682
26. Treier, M., Staszewski, L. M. and Bohmann, D. (1994) Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78, 787-798
27. Krishan, A. (1975) Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66, 188-193
28. Chu, Y. W., Wang, R., Schmid, I. and Sakamoto, K. M.. (1999) Analysis with flow cytometry of green fluorescent protein expression in leukemic cells. Cytometry 36, 333-339
29. Hengst, L. and Reed, S. I. (1996) Translational control of p27Kip1 accumulation during the cell cycle. Science 271, 1861-1864
30. Nijhara, R., Jana, S. S., Goswami, S. K., Kumar, V. and Sarkar, D. P. (2001) An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver. FEBS Lett. 504, 59-64
31. Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70
32. Harper, J. W. (1997) Cyclin dependent kinase inhibitors. Cancer Surv. 29, 91-107
33. Besson, A., Gurian-West, M., Chen, X., Kelly-Spratt, K. S., Kemp, C. J. and Roberts, J. M. (2006) A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 20, 47-64
34. Sheaff, R. J., Groudine, M., Gordon, M., Roberts, J. M. and Clurman, B. E. (1997) Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11, 1464-1478
35. Vlach, J., Hennecke, S. and Amati, B. (1997) Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16, 5334-5344
36. Sutterluty, H., Chatelain, E., Marti, A., Wirbelauer, C., Senften, M., Muller, U. and Krek, W. (1999) p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1, 207-214
37. Bashir, T., Dorrello, N. V., Amador, V., Guardavaccaro, D. and Pagano, M. (2004) Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428, 190-193
38. Brown, N. R., Noble, M. E., Endicott, J. A. and Johnson, L. N. (1999) The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. 1, 438-443
39. Connell-Crowley, L., Harper, J. W. and Goodrich, D. W. (1997) Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol. Biol. Cell 8, 287-301
40. Teodora, J. G. and Branton, P. E. (1997) Regulation of apoptosis by viral gene products. J. Virol. 71, 1739-1746
41. Banks, L., Pim, D. and Thomas, M. (2003) Viruses and the 26S proteasome: hacking into destruction. Trends Biochem. Sci. 28, 452-459
42. Bloom, J. and Pagano, M. (2003) Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin. Cancer Biol. 13, 41-47
43. Hwang, H. C. and Clurman, B. E. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24, 2776-2786
44. Hui, A. M., Makuuchi, M. and Li, X. (1998) Cell cycle regulators and human hepatocarcinogenesis. Hepatogastroenterology 45, 1635-1642
45. Skp2 complex through phosphorylated Thr187 in p27. Curr. Biol. 9, 661-664
46. Welcker, M., Singer, J., Loeb, K. R., Grim, J., Bloecher, A., Gurien-West, M., Clurman, B. E. and Roberts, J. M. (2003) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol. Cell 12, 381-392
47. Iwanaga, R., Ohtani, K., Hayashi, T. and Nakamura, M. (2001) Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 20, 2055-2067
48. Ito, Y., Matsuura, N., Sakon, M., Miyoshi, E., Noda, K., Takeda, T., Umeshita, K., Nagano, H., Nakamori, S., Dono, K. et al. (1999) 1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence. Hepatology 30, 90-99
49. Ekholm, S. V., Zickert, P., Reed, S. I. and Zetterberg, A. (2001) Accumulation of cyclin E is not a prerequisite for passage through the restriction point. Mol. Cell. Biol. 21, 3256-3265
50. Schaefer, S. and Gerlich, W. H. (1995) In vitro transformation by hepatitis B virus DNA. Intervirology 38, 143-154
51. Singh, M. and Kumar, V. (2003) Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma. Rev. Med. Virol. 13, 243-253