Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7- dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models

Archives of Pharmacal Research

Volumn 34, Issue 3, 2011, Pages 485-494

  Park, Jae Hwan ^a   Hwang, In Chang ^a   Ha, Nina ^a   Lee, Sera ^a   Kim, Jung Min ^a   Lee, Sung Sook ^a   Yu, Hosung ^a   Lim, In Taek ^a   You, Jun A ^a   Kim, Dal Hyun ^a  

^a Chong Kun Dang Research Institute   (South Korea)

Author keywords

Cecal ligation and puncture; CKD 712; Hypothermia; Interleukin 6; Nuclear factor B; Organ protection; Sepsis; Survival rate; Tumor necrosis factor

Indexed keywords

1 (ALPHA NAPHTHYLMETHYL) 6,7 DIHYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; ALANINE AMINOTRANSFERASE; ANTIINFECTIVE AGENT; ASPARTATE AMINOTRANSFERASE; CREATININE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITROGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; ZYMOSAN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY TEMPERATURE; CELL NUCLEUS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISSEMINATED INTRAVASCULAR CLOTTING; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENDOTOXEMIA; HYPOTHERMIA; INFLAMMATION; LEUKOCYTE; LIGATION; LIVER INJURY; LUNG ALVEOLUS CELL; LUNG INJURY; MALE; MORTALITY; MOUSE; NONHUMAN; ORGAN INJURY; PREMEDICATION; PUNCTURE SURGERY; RAT; SEPSIS; SURGICAL TECHNIQUE; SURVIVAL RATE; UREA NITROGEN BLOOD LEVEL;

EID: 79959960166     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0318-6     Document Type: Article

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