Inhibition of activation of nuclear factor κB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 1, 1999, Pages 314-320

  Kang, Young Jin ^a   Lee, Young Soo ^a   Lee, Goun Woo ^a   Lee, Duck Hyung ^b   Ryu, Jae Chun ^c   Yun Choi, Hye Sook ^d   Chang, Ki Churl ^a,e  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Sogang University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Seoul National University   (South Korea)

^e Gyeongsang National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HIGENAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; NORADRENALIN; PHENYLEPHRINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; GENE INACTIVATION; HYPOTENSION; INOTROPISM; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THORACIC AORTA;

ACONITUM; ALKALOIDS; ANIMALS; CELLS, CULTURED; ENDOTOXEMIA; ENDOTOXINS; HUMANS; HYBRID CELLS; HYPOTENSION; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TETRAHYDROISOQUINOLINES;

EID: 0008211999     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Chang KC, Lim JK and Park CW (1986) Synthesis of higenamine and its cardiovascular effects in rabbit: Evidence for β-adrenoceptor agonist. Kor J Pharmacol 22:96-104.
2. Chang KC, Chung SY, Chong WS, Suh JS, Kim SH, Noh HK, Seong BW, Ko HJ and Chun KW (1993a) Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 266: 992-1000.
3. Chang KC, Kim YS and Lee SY (1993b) Is the L-arginine pathway involved in photorelaxation in rat aorta? Pharmacol Commun 4:67-75.
4. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X and Demers LM (1997) Tetrandrine inhibits signal-induced NF-κB activation in rat alveolar macrophages. Biochem Biophys Res Commun 231:99-102.
5. Deng WL (1990) Anti-inflammatory agents from traditional chinese drugs. Drugs Future 15:809-816.
6. Farrell AJ, Blake DE, Palmer RM and Moncada S (1992) Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 51:1219-1222.
7. Green SJ, Meltzer MS, Hibbs JB Jr and Nacy CA (1990) Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J Immunol 144:278-283.
8. Gross SS and Levi R (1992) Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267:25722-25729.
9. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR and Stoclet JC (1990) Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 259:H1038-H1043.
10. Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh SI, Kimura T and Green SJ (1994) Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (Wash DC) 263:1612-1615.
11. G-methyl-L-arginine, an inhibitor of nitric oxide formation, acts aynergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. Crit Care Med 22:1835-1840.
12. Kimura I, Makino M, Takamura Y, Islam MA and Kimura M (1994) Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated marine atria. Jpn J Pharmacol 66:75-80.
13. Kondo Y, Takano F and Hojo H (1993a) Inhibitory effect of bifibenzylisoquinoline alkaloids on nitric oxide production in activated macrophages. Biochem Pharmacol 46:1887-1892.
14. Kondo Y, Takano F and Hojo H (1993b) Suppression of lipopolysaccharide-induced fulminant hepatitis and tumor necrosis factor production by bisbenzylisoquinoline alkaloids in bacillus Calmette-Guerin-treated mice. Biochem Pharmacol 46:1861-1863.
15. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K and Hutchinson N (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
16. Marletta MA, Tayeh MA and Hevel JM (1990) Unraveling the biological significance of nitric oxide. Biofactors 2:219-225.
17. McKenna TM (1990) Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release. J Clin Invest 86:160-168.
18. Middleton SJ, Shorthouse M and Hunter JO (1993) Relaxation of distal colonic circular smooth muscle by nitric oxide derived from human leucocytes. Gut 34: 814-817.
19. Moritoki H, Hisayama T, Kida K, Kondoh W, Inoue S and Takaishi Y (1996) Inhibition by triptoquinone-A of LPS- and IL-1 beta-primed induction of NO synthase in rat thoracic aorta. Life Sci 59:PL49-PL54.
20. Natanson C, Danner RL, Elin RJ, Hosseini JM, Peart KW, Banks SM, MacVittie TJ, Walker RI and Parrillo JE (1989) Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock. J Clin Invest 83:243-251.
21. Nishio M, Watanabe Y and Hidaka H (1998) HMN-1180, a small molecule inhibitor of neuronal nitric oxide synthase. J Pharmacol Exp Ther 287:1063-1067.
22. Park CW, Chang KC and Lim JK (1984) Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacdyn 267:279-288.
23. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA and Parrillo JE (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483-490.
24. Petros A, Bennett D and Vallance P (1991) Effect of nitric oxide gynthase inhibitors on hypotension in patients with septic shock. Lancet 338:1557-1558.
25. Sakurai H, Kohsaka H, Liu MF, Higashiyama H, Hirata Y, Kanno K, Saito I and Miyasaka N (1995) Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest 96:2357-2363.
26. Thiemermann C and Vane J (1990) Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182:591-595.
27. Vincent JL, Gris P, Coffernile M, Leon M, Pinsky M, Reuse C and Kahn RJ (1992) Myocardial depression characterizes the fatal course of septic shock. Surgery 111:660-667.
28. Vincent JL, Leon M and Berre J (1990) The role of enoximone in the treatment of cardiogenic shock. Cardiology 77(Suppl 3):21-26.
29. Wei XQ, Charles IG, Smith A, Ure J, Feng GJ, Huang FP, Xu D, Muller W, Moncada S and Liew FY (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (Lond) 375:408-411.
30. Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ and Vane JR (1995) Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci USA 92:3473-3477.
31. Xie QW, Kashiwabara Y and Nathan C (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705-4708.
32. Zhang JJ and Chen WW (1985) Protection of synovial fluid by higenamine. Acta Pharm Sin 20:423-426.