Cb1 receptor-mediated signaling emerges as a novel lead to evidence-based treatment development for stress-related psychopathology

Neuroscience Letters

Volumn 502, Issue 1, 2011, Pages 1-4

  Bailey, Christopher R ^a   Neumeister, Alexander ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID 1 RECEPTOR;

ALCOHOLISM; ANXIETY; BRAIN CORTEX; CHRONIC STRESS; HUMAN; LEARNING; MEMORY; MOOD; NONHUMAN; NOTE; PRIORITY JOURNAL; SEX DIFFERENCE; SIGNAL TRANSDUCTION; STRESS; SUBCORTEX;

ANIMALS; DRUG DELIVERY SYSTEMS; EVIDENCE-BASED MEDICINE; HUMANS; RECEPTOR, CANNABINOID, CB1; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 80051786774     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.07.011     Document Type: Note

References (81)

1. Ameri A., Wilhelm A., Simmet T. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. Br. J. Pharmacol. 1999, 126(8):1831-1839.
2. Atkinson H.C., Leggett J.D., Wood S.A., Castrique E.S., Kershaw Y.M., Lightman S.L. Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic. Endocrinology 2010, 151(8):3720-3727.
3. Bambico F.R., Cassano T., Dominguez-Lopez S., Katz N., Walker C.D., Piomelli D., Gobbi G. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology 2010, 35(10):2083-2100.
4. Basavarajappa B.S. The endocannabinoid signaling system: a potential target for next-generation therapeutics for alcoholism. Mini Rev. Med. Chem. 2007, 7(8):769-779.
5. Basavarajappa B.S., Yalamanchili R., Cravatt B.F., Cooper T.B., Hungund B.L. Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice. Neuropharmacology 2006, 50(7):834-844.
6. Blednov Y.A., Cravatt B.F., Boehm S.L., Walker D., Harris R.A. Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology 2007, 32(7):1570-1582.
7. Bowler R.M., Han H., Gocheva V., Nakagawa S., Alper H., DiGrande L., Cone J.E. Gender differences in probable posttraumatic stress disorder among police responders to the 2001 World Trade Center terrorist attack. Am. J. Ind. Med. 2010, 53(12):1186-1196.
8. Breslau N. Epidemiologic studies of trauma, posttraumatic stress disorder, and other psychiatric disorders. Can. J. Psychiatry 2002, 47(10):923-929.
9. Breslau N., Anthony J.C. Gender differences in the sensitivity to posttraumatic stress disorder: an epidemiological study of urban young adults. J. Abnorm. Psychol. 2007, 116(3):607-611.
10. Burston J.J., Wiley J.L., Craig A.A., Selley D.E., Sim-Selley L.J. Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure. Br. J. Pharmacol. 2010, 161(1):103-112.
11. Cheer J.F., Wassum K.M., Sombers L.A., Heien M.L., Ariansen J.L., Aragona B.J., Phillips P.E., Wightman R.M. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J. Neurosci. 2007, 27(4):791-795.
12. Chhatwal J.P., Davis M., Maguschak K.A., Ressler K.J. Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 2005, 30(3):516-524.
13. Colombo G., Serra S., Brunetti G., Gomez R., Melis S., Vacca G., Carai M.M., Gessa L. Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats. Psychopharmacology (Berl) 2002, 159(2):181-187.
14. Dell'osso L., Carmassi C., Massimetti G., Daneluzzo E., Di Tommaso S., Rossi A. Full and partial PTSD among young adult survivors 10months after the L'Aquila 2009 earthquake: gender differences. J. Affect. Disord. 2011, 131(1-3):79-83.
15. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258(5090):1946-1949.
16. Di Marzo V., Fontana A., Cadas H., Schinelli S., Cimino G., Schwartz J.C., Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994, 372(6507):686-691.
17. Ditlevsen D., Elklit A. The combined effect of gender and age on post traumatic stress disorder: do men and women show differences in the lifespan distribution of the disorder?. Ann. Gen. Psychiatry 2010, 9(1):32.
18. Fattore L., Fratta W. How important are sex differences in cannabinoid action?. Br. J. Pharmacol. 2010, 160(3):544-548.
19. Fegley D., Gaetani S., Duranti A., Tontini A., Mor M., Tarzia G., Piomelli D. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J. Pharmacol. Exp. Ther. 2005, 313(1):352-358.
20. Femenia T., Garcia-Gutierrez M.S., Manzanares J. CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats. Alcohol Clin. Exp. Res. 2010, 34(1):131-141.
21. Gallate J.E., Saharov T., Mallet P.E., McGregor I.S. Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist. Eur. J. Pharmacol. 1999, 370(3):233-240.
22. Galovski T.E., Mott J., Young-Xu Y., Resick P.A. Gender differences in the clinical presentation of PTSD and its concomitants in survivors of interpersonal assault. J. Interpers. Violence 2011, 26(4):789-806.
23. Gerald T.M., Howlett A.C., Ward G.R., Ho C., Franklin S.O. Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology (Berl) 2008, 198(4):497-508.
24. Gorzalka B.B., Morrish A.C., Hill M.N. Endocannabinoid modulation of male rat sexual behavior. Psychopharmacology (Berl) 2008, 198(4):479-486.
25. Gorzalka B.B., Hill M.N., Chang S.C. Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function. Horm. Behav. 2010, 58(1):91-99.
26. Haller J., Bakos N., Szirmay M., Ledent C., Freund T.F. The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur. J. Neurosci. 2002, 16(7):1395-1398.
27. Haller J., Varga B., Ledent C., Barna I., Freund T.F. Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice. Eur. J. Neurosci. 2004, 19(7):1906-1912.
28. Haller J., Varga B., Ledent C., Freund T.F. CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents. Behav. Pharmacol. 2004, 15(4):299-304.
29. Harte L.C., Dow-Edwards D. Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat. Neurotoxicol. Teratol. 2010, 32(5):515-524.
30. Herkenham M. Characterization and localization of cannabinoid receptors in brain: an in vitro technique using slide-mounted tissue sections. NIDA Res. Monogr. 1991, 112:129-145.
31. Herkenham M., Lynn A.B., Little M.D., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. U.S.A. 1990, 87(5):1932-1936.
32. Herkenham M., Groen B.G., Lynn A.B., De Costa B.R., Richfield E.K. Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum. Brain Res. 1991, 552(2):301-310.
33. Hill M.N., McEwen B.S. Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34(5):791-797.
34. Hill M.N., Patel S., Carrier E.J., Rademacher D.J., Ormerod B.K., Hillard C.J., Gorzalka B.B. Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology 2005, 30(3):508-515.
35. Hill M.N., Karacabeyli E.S., Gorzalka B.B. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology 2007, 32(4):350-357.
36. Hill M.N., Miller G.E., Ho W.S., Gorzalka B.B., Hillard C.J. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. Pharmacopsychiatry 2008, 41(2):48-53.
37. Hill M.N., Carrier E.J., Ho W.S., Shi L., Patel S., Gorzalka B.B., Hillard C.J. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. Hippocampus 2008, 18(2):221-226.
38. Hill M.N., Carrier E.J., McLaughlin R.J., Morrish A.C., Meier S.E., Hillard C.J., Gorzalka B.B. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. J. Neurochem. 2008, 106(6):2322-2336.
39. Hill M.N., McLaughlin R.J., Morrish A.C., Viau V., Floresco S.B., Hillard C.J., Gorzalka B.B. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology 2009, 34(13):2733-2745.
40. Hill M.N., Patel S., Campolongo P., Tasker J.G., Wotjak C.T., Bains J.S. Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. J. Neurosci. 2010, 30(45):14980-14986.
41. Hungund B.L., Szakall I., Adam A., Basavarajappa B.S., Vadasz C. Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens. J. Neurochem. 2003, 84(4):698-704.
42. Irish L.A., Fischer B., Fallon W., Spoonster E., Sledjeski E.M., Delahanty D.L. Gender differences in PTSD symptoms: an exploration of peritraumatic mechanisms. J. Anxiety Disord. 2011, 25(2):209-216.
43. Kathuria S., Gaetani S., Fegley D., Valino F., Duranti A., Tontini A., Mor M., Tarzia G., La Rana G., Calignano A., Giustino A., Tattoli M., Palmery M., Cuomo V., Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nat. Med. 2003, 9(1):76-81.
44. Koob G.F. Drug abuse and alcoholism. Overview. Adv. Pharmacol. 1998, 42:969-977.
45. Krebs-Kraft D.L., Hill M.N., Hillard C.J., McCarthy M.M. Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(47):20535-20540.
46. Lazarus R.S., Fokman S. Stress, Appraisal, and Coping 1984, Springer, New York.
47. Lopez-Gallardo M., Llorente R., Llorente-Berzal A., Marco E.M., Prada C., Di Marzo V., Viveros M.P. Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation. Dev. Neurobiol. 2008, 68(12):1429-1440.
48. Luxton D.D., Skopp N.A., Maguen S. Gender differences in depression and PTSD symptoms following combat exposure. Depress. Anxiety 2010, 27(11):1027-1033.
49. Maccioni P., Pes D., Carai M.A., Gessa G.L., Colombo G. Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats. Behav. Pharmacol. 2008, 19(3):197-209.
50. Maccioni P., Colombo G., Carai M.A. Blockade of the cannabinoid CB1 receptor and alcohol dependence: preclinical evidence and preliminary clinical data. CNS Neurol. Disord. Drug Targets 2010, 9(1):55-59.
51. Mackie K. Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb. Exp. Pharmacol. 2005, 168:299-325.
52. Mailleux P., Vanderhaeghen J.J. Glucocorticoid regulation of cannabinoid receptor messenger RNA levels in the rat caudate-putamen. An in situ hybridization study. Neurosci. Lett. 1993, 156(1-2):51-53.
53. Malinen H., Hyytia P. Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats. Alcohol. Clin. Exp. Res. 2008, 32(11):1976-1983.
54. Mangieri R.A., Hong K.I., Piomelli D., Sinha R. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology (Berl) 2009, 205(1):63-72.
55. Marsicano G., Wotjak C.T., Azad S.C., Bisogno T., Rammes G., Cascio M.G., Hermann H., Tang J., Hofmann C., Zieglgansberger W., Di Marzo V., Lutz B. The endogenous cannabinoid system controls extinction of aversive memories. Nature 2002, 418(6897):530-534.
56. Martin M., Ledent C., Parmentier M., Maldonado R., Valverde O. Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology 2002, 159(4):379-387.
57. Matsuda L.A., Bonner T.I., Lolait S.J. Localization of cannabinoid receptor mRNA in rat brain. J. Comp. Neurol. 1993, 327(4):535-550.
58. McEwen B.S. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 2000, 22(2):108-124.
59. Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R., Pertweee R.G., Griffine G., Bayewitchf M., Bargf J., Vogelf Z. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 1995, 50(1):83-90.
60. Naassila M., Pierrefiche O., Ledent C., Daoust M. Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. Neuropharmacology 2004, 46(2):243-253.
61. Piomelli D. The endocannabinoid system: a drug discovery perspective. Curr. Opin. Investig. Drugs 2005, 6(7):672-679.
62. Poncelet M., Maruani J., Calassi R., Soubrie P. Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice. Neurosci. Lett. 2003, 343(3):216-218.
63. Rademacher D.J., Meier S.E., Shi L., Ho W.S., Jarrahian A., Hillard C.J. Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology 2008, 54(1):108-116.
64. Reich C.G., Taylor M.E., McCarthy M.M. Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats. Behav. Brain Res. 2009, 203(2):264-269.
65. Selye H. The Stress of Life 1976, McGraw-Hill, New York.
66. Sinha R. The role of stress in addiction relapse. Curr. Psychiatry Rep. 2007, 9(5):388-395.
67. Stella N., Schweitzer P., Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature 1997, 388(6644):773-778.
68. Suarez J., Llorente R., Romero-Zerbo S.Y., Mateos B., Bermudez-Silva F.J., de Fonseca F.R., Viveros M.P. Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats. Hippocampus 2009, 19(7):623-632.
69. Sugiura T., Kondo S., Sukagawa A., Nakane S., Shinoda A., Itoh K., Yamashita A., Waku K. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 1995, 215(1):89-97.
70. Tang S.L., Wagner E.J. Gender differences in the cannabinoid modulation of an A-type K1 current in neurons of the mammalian hypothalamus. J. Am. Osteopath. Assoc. 2005, 105(1):26-27.
71. Tang S.L., Tran V., Wagner E.J. Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus. J. Neurophysiol. 2005, 94(4):2983-2986.
72. Thanos P.K., Dimitrakakis E.S., Rice O., Gifford A., Volkow N.D. Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors. Behav. Brain Res. 2005, 164(2):206-213.
73. Van Laere K., Goffin K., Casteels C., Dupont P., Mortelmans L., de Hoon J., Bormans G. Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. Neuroimage 2008, 39(4):1533-1541.
74. Van Sickle M.D., Duncan M., Kingsley P.J., Mouihate A., Urbani P., Mackie K., Stella N., Makriyannis A., Piomelli D., Davison J.S., Marnett L.J., Di Marzo V., Pittman Q.J., Patel K.D., Sharkey K.A. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 2005, 310(5746):329-332.
75. Varvel S.A., Wise L.E., Niyuhire F., Cravatt B.F., Lichtman A.H. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology 2007, 32(5):1032-1041.
76. Vinod K.Y., Yalamanchili R., Thanos P.K., Vadasz C., Cooper T.B., Volkow N.D., Hungund B.L. Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice. Synapse 2008, 62(8):574-581.
77. Vinod K.Y., Kassir S.A., Hungund B.L., Cooper T.B., Mann J.J., Arango V. Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. J. Psychiatry Res. 2010, 44(9):591-597.
78. Viveros M.P., de Fonseca F.R., Bermudez-Silva F.J., McPartland J.M. Critical role of the endocannabinoid system in the regulation of food intake and energy metabolism, with phylogenetic, developmental, and pathophysiological implications. Endocr. Metab. Immune Disord. Drug Targets 2008, 8(3):220-230.
79. Ward S.J., Walker E.A. Sex and cannabinoid CB1 genotype differentiate palatable food and cocaine self-administration behaviors in mice. Behav. Pharmacol. 2009, 20(7):605-613.
80. Xing G., Carlton J., Zhang L., Jiang X., Fullerton C., Li H., Ursano R. Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: implication for PTSD and drug abuse. Neurosci. Lett. 2011.
81. Yehuda R. Status of glucocorticoid alterations in post-traumatic stress disorder. Ann. N. Y. Acad. Sci. 2009, 1179:56-69.