Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides

Journal of Psychiatric Research

Volumn 44, Issue 9, 2010, Pages 591-597

  Vinod, K Yaragudri ^a,b,c   Kassir, Suham A ^c   Hungund, Basalingappa L ^a,c,d   Cooper, Thomas B ^a,c,d   Mann, J John ^c,d   Arango, Victoria ^c,d  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d Columbia University ^*  (United States)

Author keywords

Alcoholism; Anandamide; Cannabinoid; G protein; Striatum; Suicide

Indexed keywords

CANNABINOID 1 RECEPTOR; FATTY ACID AMIDASE; GUANINE NUCLEOTIDE BINDING PROTEIN;

ADOLESCENT; ADULT; AGED; ALCOHOLISM; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUICIDE; UPREGULATION;

ADOLESCENT; ADULT; AGED; ALCOHOLISM; AMIDOHYDROLASES; ANALYSIS OF VARIANCE; AUTORADIOGRAPHY; BASAL GANGLIA; GENE EXPRESSION REGULATION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; IMIPRAMINE; MALE; MIDDLE AGED; POSTMORTEM CHANGES; PROTEIN BINDING; RECEPTOR, CANNABINOID, CB1; SUICIDE; TRITIUM; YOUNG ADULT;

EID: 77953291374     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.11.013     Document Type: Article

References (68)

1. Arango V., Underwood M.D., Mann J.J. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002, 136:443-453.
2. Basavarajappa B.S., Cooper T.B., Hungund B.L. Chronic ethanol administration down-regulates cannabinoid receptors in mouse brain synaptic plasma membrane. Brain Res 1998, 79:212-218.
3. Blednov Y.A., Cravatt B.F., Boehm S.L., Walker D., Harris R.A. Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology 2007, 32:1570-1582.
4. Callado L.F., Meana J.J., Grijalba B., Pazos A., Sastre M., Garcia-Sevilla J.A. Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims. J Neurochem 1998, 70:1114-1123.
5. Cheer J.F., Wassum K.M., Sombers L.A., et al. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci 2007, 27:791-795.
6. Chiang K.P., Gerber A.L., Sipe J.C., Cravatt B.F. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Human Mol Genet 2004, 13:2113-2119.
7. Childers S.R., Breivogel C.S. The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis 1998, 5:417-431.
8. Deutsch D.G., Glaser S.T., Howell J.M., Kunz J.S., Puffenbarger R.A., Hillard C.J., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. J Biol Chem 2001, 276:6967-6973.
9. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258:1946-1949.
10. Di Marzo V., De Petrocellis L., Bisogno T., Melck D. Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments. Lipids 1999, 34:319-325.
11. 3H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims. Am J Psychiat 2002, 159:66-73.
12. Dwivedi Y., Rao J.S., Rizavi H.S., et al. Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subject. Arch Gen Psychiat 2003, 60:273-282.
13. Eisch A.J., Bolanos C.A., de Wit J., Simonak R.D., Pudiak C.M., Barrot M., et al. Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiat 2003, 54:994-1005.
14. Glass M., Dragunow M., Faull R.L. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 1997, 77:299-318.
15. Gonzalez S., Cascio M.G., Fernandez-Ruiz J., Fezza F., Di Marzo V., Ramos J.A. Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. Brain Res 2002, 954:73-81.
16. Gonzalez S., Valenti M., de Miguel R., Fezza F., Fernandez-Ruiz J., Di Marzo V., et al. Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse. Br J Pharmacol 2004, 143:455-464.
17. 2A-adrenoceptors. Mol Psychiat 2002, 7:755-767.
18. Hansson A.C., Bermudez-Silva F.J., Malinen H., et al. Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology 2007, 32:117-126.
19. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., deCost B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain; a quantitative in vitro autoradiographic study. J Neurosci 1991, 16:8057-8066.
20. Howlett A.C. Cannabinoid receptor signaling. In: Handbook of experimental pharmacology, vol. 68; 2005. p. 53-79.
21. Hungund B.L., Szakall I., Adam A., Basavarajappa B.S., Vadasz C. Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens. J Neurochem 2003, 84:698-704.
22. 35S]GTPγS binding in the prefrontal cortex of depressed suicide victims. Mol Psychiat 2004, 9:184-190.
23. Juckel G., Schlagenhauf F., Koslowski M., Filonov D., Wüstenberg T., Villringer A., et al. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology 2006, 187:222-228.
24. Kamprath K., Plendl W., Marsicano G., Deussing J.M., Wurst W., Lutz B., et al. Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. Gene Brain Behav 2009, 8:203-211.
25. Kelly T.M., Mann J.J. Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with antemortem diagnosis. Acta Psychiat Scand 1996, 94:337-343.
26. Kessler R.C., Borges G., Walters E.E. Prevalence of risk factors for lifetime suicide attempts in the National Comorbidity Survey. Archiv Gen Psychiat 1999, 56:617-626.
27. Koller G., Preuss U.W., Bottlender M., Wenzel K., Soyka M. Impulsivity and aggression as predictors of suicide attempts in alcoholics. European. Archiv Psychiat Clin Neurosci 2002, 252:155-160.
28. Kreitzer A.C., Regehr W.G. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 2001, 29:717-727.
29. Kumar P., Waiter G., Ahearn T., Milders M., Reid I., Steele J.D. Abnormal temporal difference reward-learning signals in major depression. Brain 2008, 131:2084-2093.
30. Lowry O.H., Rosebrough N.J., Farr A.G., Randall R.J. Protein measurement with folin phenol reagent. J Biol Chem 1951, 193:265-275.
31. Makhija N.J., Sher L. Preventing suicide in adolescents with alcohol use disorders. Int J Adolesc Med Health 2007, 19:53-59.
32. Malinen H., Hyytia P. Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats. Alcohol Clin Exp Res 2008, 32:1976-1983.
33. Mangieri R.A., Piomelli D. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacol Res 2007, 56:360-366.
34. Mann J.J. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003, 4:819-828.
35. Mann J.J., Waternaux C., Haas G.L., Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiat 1999, 156:181-189.
36. McDonald J., Schleifer L., Richards J.B., de Wit H. Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology 2003, 28:1356-1365.
37. Mitrirattanakul S., López-Valdés H.E., Liang J., Matsuka Y., Mackie K., Faull K.F., et al. Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence. Alcohol Clin Exp Res 2007, 31:855-867.
38. Ortiz S., Oliva J.M., Pérez-Rial S., Palomo T., Manzanares J. Chronic ethanol consumption regulates cannabinoid CB1 receptor gene expression in selected regions of rat brain. Alcohol Alcohol 2004, 39:88-92.
39. Pandey G.N., Dwivedi Y., Rizavi H.S., Ren X., Pandey S.C., Pesold C., et al. Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. Am J Psychiat 2002, 159:419-429.
40. Patel S., Hillard C.J. Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur J Neurosci 2008, 27:2821-2829.
41. Patel S., Rademacher D.J., Hillard C.J. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. J Pharmacol Exp Therapeut 2003, 306:880-888.
42. Patel S., Roelke C.T., Rademacher D.J., Cullinan W.E., Hillard C.J. Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 2004, 145:5431-5438.
43. Pattij T., Vanderschuren L.J. The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci 2008, 29:192-199.
44. Potash J.B., Kane H.S., Chiu Y.F., Simpson S.G., McKinnon D.F., et al. Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships. Am J Psychiat 2000, 157:2048-2050.
45. Preuss U.W., Schuckit M.A., Smith T.L., Danko G.R., Dasher A.C., Hesselbrock M.N., et al. A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attempts. J Stud Alcohol 2002, 63:498-502.
46. Reiach J.S., Li P.P., Warsh J.J., Kish S.J., Young L.T. Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims. Affect Disorder 1999, 56:141-151.
47. Rich C.L., Dhossche D.M., Ghani S., Isacsson G. Suicide methods and presence of intoxicating abusable substances: some clinical and public health implications. Annals Clin Psychiat 1998, 10:169-175.
48. Richardson H.N., Lee S.Y., O'Dell L.E., Koob G.F., Rivier C.L. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci 2008, 28:1641-1653.
49. Roy A. Relation of family history of suicide to suicide attempts in alcoholics. Am J Psychiat 2000, 157:2050-2051.
50. Schmidt L.G., Samochowiec J., Finckh U., Fiszer-Piosik E., Horodnicki J., Wendel B., et al. Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Drug Alcohol Depend 2002, 65:221-224.
51. Self D.W., Nestler E.J. Relapse to drug-seeking: neural and molecular mechanisms. Drug Alcohol Depend 1998, 51:49-60.
52. Sher L. The role of the hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of alcohol misuse and suicidal behavior in adolescents. Int J Adolesc Med Health 2007, 19:3-9.
53. Sipe J.C., Chiang K., Gerber A.L., Beutler E., Cravatt B.F. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc Notat Acad Sci 2002, 99:8394-8399.
54. Solinas M., Justinova J., Goldberg S.R., Tanda G.J. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rat. J Neurochem 2006, 98:408-419.
55. Solinas M., Tanda G., Justinova Z., Wertheim C.E., Yasar S., Piomelli D., et al. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. J Pharmacol Exp Therapeut 2007, 321:370-380.
56. Steiner M.A., Wanisch K., Monory K., Marsicano G., Borroni E., Bächli H., et al. Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. Pharmacogenom J 2008, 8:196-208.
57. Steiner M.A., Marsicano G., Nestler E.J., Holsboer F., Lutz B., Wotjak C.T. Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology 2008, 33:54-67.
58. Suominen K., Henriksson M., Suokas J., Isometsa E., Ostamo A., Lonnqvist J. Mental disorders and comorbidity in attempted suicide. Acta Psychiat Scand 1996, 94:234-240.
59. Tremblay L.K., Naranjo C.A., Graham S.J., Herrmann N., Mayberg H.S., Hevenor S., et al. Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Archiv Gen Psychiat 2005, 62:1228-1236.
60. Underwood M.D., Mann J.J., Huang Y.Y., Arango V. Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex. Alcohol Clin Exp Res 2008, 32:593-599.
61. Vinod K.Y., Hungund B.L. The role of endocannabinoid system in depression and suicide. Trends Pharmacol Sci 2006, 27:539-545.
62. Vinod K.Y., Arango V., Kassir S.A., Cooper T.B., Mann J.J., Hungund B.L. Elevated levels of endocannabinoids, CB1 receptors and agonist-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims. Biol Psychiat 2005, 57:480-486.
63. Vinod K.Y., Yalamanchilli R., Xie S., Cooper R., Hungund B.L. Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system. Neurochem Int 2006, 49:619-625.
64. Vinod K.Y., Sanguino E., Yalamanchili R., Manzanares J., Hungund B.L. Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol. J Neurochem 2008, 104:233-243.
65. Vinod K.Y., Yalamanchili R., Xie S., Ramalhete R., Michaelides M., Thanos P.K., et al. Genetic and pharmacological manipulations of the CB1 receptor alter ethanol consumption and dependence in ethanol preferring and non-preferring mice. Synapse 2008, 62:574-581.
66. Wang L., Liu J., Harvey-White J., Zimmer A., Kunos G. Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Notat Acad Sci 2003, 100:1393-1398.
67. Wilson R.I., Nicoll R.A. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 2001, 410:588-592.
68. Zuo L., Kranzler H.R., Luo X., Covault J., Gelernter J. CNR1 variation modulates risk for drug and alcohol dependence. Biol Psychiat 2007, 62:616-626.