Coordinated expression of Pax-5 and FAK1 in metastasis

Anti-Cancer Agents in Medicinal Chemistry

Volumn 11, Issue 7, 2011, Pages 643-649

  Crapoulet, Nicolas ^a   O'Brien, Pierre ^a,b   Ouellette, Rodney J ^a,b   Robichaud, Gilles A ^a,b  

^a ATLANTIC CANCER RESEARCH INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONCTON   (Canada)

Author keywords

Cancer; Cell signaling; FAK1; Focal adhesion; Metastasis; Pax 5

Indexed keywords

CALPAIN 2; CD79A ANTIGEN; CD79B ANTIGEN; FOCAL ADHESION KINASE 1; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR PAX5;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BREAST CANCER; CANCER CELL; CANCER INVASION; CANCER SURVIVAL; CARCINOGENESIS; CARCINOMA CELL; CELL INTERACTION; CELL MIGRATION; DISTANT METASTASIS; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; LYMPHOPOIESIS; METASTASIS; NONHODGKIN LYMPHOMA; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 80051731432     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152011796817637     Document Type: Article

References (91)

1. Robson, E. J.; He, S. J.; Eccles, M. R., A PANorama of PAX genes in cancer and development. Nature Rev. Cancer, 2006, 6(1), 52-62.
2. Carotta, S.; Brady, J.; Wu, L.; Nutt, S. L., Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells. Eur. J. Immunol., 2006, 36(12), 3294-3304.
3. Holmes, M. L.; Pridans, C.; Nutt, S. L., The regulation of the B-cell gene expression programme by Pax5. Immunol. Cell Biol., 2008, 86(1), 47-53.
4. Delogu, A.; Schebesta, A.; Sun, Q.; Aschenbrenner, K.; Perlot, T.; Busslinger, M., Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity, 2006, 24(3), 269-281.
5. Krenacs, L.; Himmelmann, A. W.; Quintanilla-Martinez, L.; Fest, T.; Riva, A.; Wellmann, A.; Bagdi, E.; Kehrl, J. H.; Jaffe, E. S.; Raffeld, M., Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of Bcell lymphomas. Blood, 1998, 92(4), 1308-1316.
6. Tiacci, E.; Pileri, S.; Orleth, A.; Pacini, R.; Tabarrini, A.; Frenguelli, F.; Liso, A.; Diverio, D.; Lo-Coco, F.; Falini, B., PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. Cancer Res., 2004, 64(20), 7399-7404.
7. Poppe, B.; De Paepe, P.; Michaux, L.; Dastugue, N.; Bastard, C.; Herens, C.; Moreau, E.; Cavazzini, F.; Yigit, N.; Van Limbergen, H.; De Paepe, A.; Praet, M.; De Wolf-Peeters, C.; Wlodarska, I.; Speleman, F., PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements. Genes Chromosomes Cancer, 2005, 44(2), 218-223.
8. Ohno, H.; Ueda, C.; Akasaka, T., The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma. Leuk. Lymphoma, 2000, 36(5-6), 435-445.
9. Nebral, K.; Konig, M.; Harder, L.; Siebert, R.; Haas, O. A.; Strehl, S., Identification of PML as novel PAX5 fusion partner in childhood acute lymphoblastic leukaemia. Br. J. Haematol., 2007, 139(2), 269-274.
10. Bousquet, M.; Broccardo, C.; Quelen, C.; Meggetto, F.; Kuhlein, E.; Delsol, G.; Dastugue, N.; Brousset, P., A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5. Blood, 2007, 109(8), 3417-3423.
11. Cazzaniga, G.; Daniotti, M.; Tosi, S.; Giudici, G.; Aloisi, A.; Pogliani, E.; Kearney, L.; Biondi, A., The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case. Cancer Res., 2001, 61(12), 4666-4670.
12. Fazio, G.; Palmi, C.; Rolink, A.; Biondi, A.; Cazzaniga, G., PAX5/TEL acts as a transcriptional repressor causing downmodulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells. Cancer Res., 2008, 68(1), 181-189.
13. Robichaud, G. A.; Perreault, J. P.; Ouellette, R. J., Development of an isoform-specific gene suppression system: the study of the human Pax-5B transcriptional element. Nucleic Acids Research, 2008, 36(14), 4609-4620.
14. Cozma, D.; Yu, D.; Hodawadekar, S.; Azvolinsky, A.; Grande, S.; Tobias, J. W.; Metzgar, M. H.; Paterson, J.; Erikson, J.; Marafioti, T.; Monroe, J. G.; Atchison, M. L.; Thomas-Tikhonenko, A., B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling. J. Clin. Invest., 2007, 117(9), 2602-2610.
15. Liu, W.; Li, X.; Chu, E. S.; Go, M. Y.; Xu, L.; Zhao, G.; Li, L.; Dai, N.; Si, J.; Tao, Q.; Sung, J. J.; Yu, J., Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway. Hepatology, 2011.
16. Kanteti, R.; Nallasura, V.; Loganathan, S.; Tretiakova, M.; Kroll, T.; Krishnaswamy, S.; Faoro, L.; Cagle, P.; Husain, A. N.; Vokes, E. E.; Lang, D.; Salgia, R., PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. Lab. Invest., 2009, 89(3), 301-314.
17. Vidal, L. J.; Perry, J. K.; Vouyovitch, C. M.; Pandey, V.; Brunet-Dunand, S. E.; Mertani, H. C.; Liu, D. X.; Lobie, P. E., PAX5alpha enhances the epithelial behavior of human mammary carcinoma cells. Mol. Cancer Res., 2010, 8(3), 444-456.
18. Vouyovitch, C. M.; Vidal, L.; Borges, S.; Raccurt, M.; Arnould, C.; Chiesa, J.; Lobie, P. E.; Lachuer, J.; Mertani, H. C., Proteomic analysis of autocrine/paracrine effects of human growth hormone in human mammary carcinoma cells. Adv. Exp. Med. Biol., 2008, 617, 493-500.
19. Hugo, H.; Ackland, M. L.; Blick, T.; Lawrence, M. G.; Clements, J. A.; Williams, E. D.; Thompson, E. W., Epithelial-mesenchymal and mesenchymal--epithelial transitions in carcinoma progression. J. Cell Physiol., 2007, 213(2), 374-383.
20. Ellsworth, R. E.; Seebach, J.; Field, L. A.; Heckman, C.; Kane, J.; Hooke, J. A.; Love, B.; Shriver, C. D., A gene expression signature that defines breast cancer metastases. Clin. Exp. Metastasis, 2009, 26(3), 205-213.
21. Balasenthil, S.; Gururaj, A. E.; Talukder, A. H.; Bagheri-Yarmand, R.; Arrington, T.; Haas, B. J.; Braisted, J. C.; Kim, I.; Lee, N. H.; Kumar, R., Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res., 2007, 67(15), 7132-7138.
22. Schebesta, A.; McManus, S.; Salvagiotto, G.; Delogu, A.; Busslinger, G. A.; Busslinger, M., Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity, 2007, 27(1), 49-63.
23. Barrett, T.; Troup, D. B.; Wilhite, S. E.; Ledoux, P.; Evangelista, C.; Kim, I. F.; Tomashevsky, M.; Marshall, K. A.; Phillippy, K. H.; Sherman, P. M.; Muertter, R. N.; Holko, M.; Ayanbule, O.; Yefanov, A.; Soboleva, A., NCBI GEO: archive for functional genomics data sets--10 years on. Nucleic Acids Res., 2011, 39, (Database issue), D1005-10.
24. Smyth, G. K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 2004, 3, Article3.
25. Smyth, G. K.; Speed, T., Normalization of cDNA microarray data. Methods, 2003, 31(4), 265-273.
26. Bolos, V.; Gasent, J. M.; Lopez-Tarruella, S.; Grande, E., The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco. Targets Ther., 2010, 3, 83-97.
27. Schaller, M. D.; Borgman, C. A.; Cobb, B. S.; Vines, R. R.; Reynolds, A. B.; Parsons, J. T., Pp125fak a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA 1992, 89(11), 5192-5196.
28. Hanks, S. K.; Calalb, M. B.; Harper, M. C.; Patel, S. K., Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA 1992, 89(18), 8487-8491.
29. Whitney, G. S.; Chan, P. Y.; Blake, J.; Cosand, W. L.; Neubauer, M. G.; Aruffo, A.; Kanner, S. B., Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. DNA Cell Biol., 1993, 12(9), 823-830.
30. Weiner, T. M.; Liu, E. T.; Craven, R. J.; Cance, W. G., Expression of focal adhesion kinase gene and invasive cancer. Lancet, 1993, 342(8878), 1024-1025.
31. Mitra, S. K.; Hanson, D. A.; Schlaepfer, D. D., Focal adhesion kinase: in command and control of cell motility. Nat. Rev. Mol. Cell Biol., 2005, 6(1), 56-68.
32. Sieg, D. J.; Hauck, C. R.; Ilic, D.; Klingbeil, C. K.; Schaefer, E.; Damsky, C. H.; Schlaepfer, D. D., FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol., 2000, 2(5), 249-256.
33. Zheng, C.; Xing, Z.; Bian, Z. C.; Guo, C.; Akbay, A.; Warner, L.; Guan, J. L., Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J. Biol. Chem., 1998, 273(4), 2384-2389.
34. Guo, W.; Giancotti, F. G., Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol., 2004, 5(10), 816-826.
35. Canel, M.; Secades, P.; Rodrigo, J. P.; Cabanillas, R.; Herrero, A.; Suarez, C.; Chiara, M. D., Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number. Clin. Cancer Res., 2006, 12(11 Pt 1), 3272-3279.
36. Gutenberg, A.; Bruck, W.; Buchfelder, M.; Ludwig, H. C., Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas. Acta Neuropathol., 2004, 108(3), 224-230.
37. Cance, W. G.; Craven, R. J.; Weiner, T. M.; Liu, E. T., Novel protein kinases expressed in human breast cancer. Int. J.Cancer, 1993, 54(4), 571-577.
38. Cance, W. G.; Harris, J. E.; Iacocca, M. V.; Roche, E.; Yang, X.; Chang, J.; Simkins, S.; Xu, L., Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin. Cancer Res., 2000, 6(6), 2417-2423.
39. Kim, S. J.; Park, J. W.; Yoon, J. S.; Mok, J. O.; Kim, Y. J.; Park, H. K.; Kim, C. H.; Byun, D. W.; Lee, Y. J.; Jin, S. Y.; Suh, K. I.; Yoo, M. H., Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. J. Korean Med. Sci., 2004, 19(5), 710-715.
40. Lacoste, J.; Aprikian, A. G.; Chevalier, S., Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility. Mol. Cell Endocrinol., 2005, 235(1-2), 51-61.
41. Lark, A. L.; Livasy, C. A.; Calvo, B.; Caskey, L.; Moore, D. T.; Yang, X.; Cance, W. G., Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin. Cancer Res., 2003, 9(1), 215-222.
42. Ayaki, M.; Komatsu, K.; Mukai, M.; Murata, K.; Kameyama, M.; Ishiguro, S.; Miyoshi, J.; Tatsuta, M.; Nakamura, H., Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin. Cancer Res., 2001, 7(10), 3106-3112.
43. Xu, L. H.; Yang, X.; Bradham, C. A.; Brenner, D. A.; Baldwin, A. S., Jr.; Craven, R. J.; Cance, W. G., The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptorrelated signaling pathways. J. Biol. Chem., 2000, 275(39), 30597-30604.
44. Ilic, D.; Almeida, E. A.; Schlaepfer, D. D.; Dazin, P.; Aizawa, S.; Damsky, C. H., Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell Biol., 1998, 143(2), 547-560.
45. Xu, L. H.; Owens, L. V.; Sturge, G. C.; Yang, X.; Liu, E. T.; Craven, R. J.; Cance, W. G., Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ., 1996, 7(4), 413-418.
46. Sonoda, Y.; Matsumoto, Y.; Funakoshi, M.; Yamamoto, D.; Hanks, S. K.; Kasahara, T., Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J. Biol. Chem., 2000, 275(21), 16309-16315.
47. Bunek, J.; Kamarajan, P.; Kapila, Y., Anoikis mediators in oral squamous cell carcinoma. Oral Dis., 2011, 17(4), 355-361.
48. Bouchard, V.; Demers, M. J.; Thibodeau, S.; Laquerre, V.; Fujita, N.; Tsuruo, T.; Beaulieu, J. F.; Gauthier, R.; Vezina, A.; Villeneuve, L.; Vachon, P. H., Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J. Cell Physiol., 2007, 212(3), 717-728.
49. Frisch, S. M.; Vuori, K.; Ruoslahti, E.; Chan-Hui, P. Y., Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol., 1996, 134(3), 793-799.
50. Zhu, J.; Wang, Y. S.; Zhang, J.; Zhao, W.; Yang, X. M.; Li, X.; Jiang, T. S.; Yao, L. B., Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells. Exp. Eye Res., 2009, 88(5), 910-918.
51. Lim, S. T.; Chen, X. L.; Lim, Y.; Hanson, D. A.; Vo, T. T.; Howerton, K.; Larocque, N.; Fisher, S. J.; Schlaepfer, D. D.; Ilic, D., Nuclear FAK promotes cell proliferation and survival through FERMenhanced p53 degradation. Mo.l Cell, 2008, 29(1), 9-22.
52. Cary, L. A.; Chang, J. F.; Guan, J. L., Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci., 1996, 109(Pt 7), 1787-1794.
53. Hauck, C. R.; Sieg, D. J.; Hsia, D. A.; Loftus, J. C.; Gaarde, W. A.; Monia, B. P.; Schlaepfer, D. D., Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res., 2001, 61(19), 7079-7090.
54. Jones, G.; Machado, J., Jr.; Merlo, A., Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells. Cancer Res., 2001, 61(13), 4978-4981.
55. Haskell, H.; Natarajan, M.; Hecker, T. P.; Ding, Q.; Stewart, J., Jr.; Grammer, J. R.; Gladson, C. L., Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells. Clin, Cancer Res., 2003, 9(6), 2157-2165.
56. Angelucci, A.; Bologna, M., Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family. Curr. Pharm. Des., 2007, 13(21), 2129-2145.
57. Duxbury, M. S.; Ito, H.; Benoit, E.; Zinner, M. J.; Ashley, S. W.; Whang, E. E., RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochem Biophys. Res. Commun., 2003, 311(3), 786-792.
58. Itoh, S.; Maeda, T.; Shimada, M.; Aishima, S.; Shirabe, K.; Tanaka, S.; Maehara, Y., Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin. Cancer Res., 2004, 10(8), 2812-2817.
59. Miyazaki, T.; Kato, H.; Nakajima, M.; Sohda, M.; Fukai, Y.; Masuda, N.; Manda, R.; Fukuchi, M.; Tsukada, K.; Kuwano, H., FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br. J. Cancer, 2003, 89(1), 140-145.
60. Sood, A. K.; Coffin, J. E.; Schneider, G. B.; Fletcher, M. S.; DeYoung, B. R.; Gruman, L. M.; Gershenson, D. M.; Schaller, M. D.; Hendrix, M. J., Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am. J. Pathol., 2004, 165(4), 1087-1095.
61. Bailey, K. M.; Liu, J., Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J. Biol. Chem., 2008, 283(20), 13714-13724.
62. Cicchini, C.; Laudadio, I.; Citarella, F.; Corazzari, M.; Steindler, C.; Conigliaro, A.; Fantoni, A.; Amicone, L.; Tripodi, M., TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling. Exp. Cell Res., 2008, 314(1), 143-152.
63. Hsia, D. A.; Mitra, S. K.; Hauck, C. R.; Streblow, D. N.; Nelson, J. A.; Ilic, D.; Huang, S.; Li, E.; Nemerow, G. R.; Leng, J.; Spencer, K. S.; Cheresh, D. A.; Schlaepfer, D. D., Differential regulation of cell motility and invasion by FAK. J. Cell Biol., 2003, 160(5), 753-767.
64. Shibata, K.; Kikkawa, F.; Nawa, A.; Thant, A. A.; Naruse, K.; Mizutani, S.; Hamaguchi, M., Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells. Cancer Res., 1998, 58(5), 900-903.
65. Irby, R. B.; Yeatman, T. J., Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. Cancer Res., 2002, 62(9), 2669-2674.
66. Avizienyte, E.; Frame, M. C., Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr. Opin. Cell Biol., 2005, 17(5), 542-547.
67. Lightfoot, H. M., Jr.; Lark, A.; Livasy, C. A.; Moore, D. T.; Cowan, D.; Dressler, L.; Craven, R. J.; Cance, W. G., Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res. Treat., 2004, 88(2), 109-116.
68. van Nimwegen, M. J.; van de Water, B., Focal adhesion kinase: a potential target in cancer therapy. Biochem. Pharmacol., 2007, 73(5), 597-609.
69. Parsons, J. T.; Slack-Davis, J.; Tilghman, R.; Roberts, W. G., Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin. Cancer Res., 2008, 14(3), 627-632.
70. Hollstein, M.; Sidransky, D.; Vogelstein, B.; Harris, C. C., P53 mutations in human cancers. Science, 1991, 253(5015), 49-53.
71. Garg, A.; Aggarwal, B. B., Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia, 2002, 16(6), 1053-1068.
72. Golubovskaya, V.; Kaur, A.; Cance, W., Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim. Biophys. Acta, 2004, 1678(2-3), 111-125.
73. Golubovskaya, V. M.; Finch, R.; Kweh, F.; Massoll, N. A.; Campbell-Thompson, M.; Wallace, M. R.; Cance, W. G., P53 regulates FAK expression in human tumor cells. Mol Carcinog 2008, 47(5), 373-82.
74. O'Brien, P., The role of Pax-5 and its alternatively spliced isoforms in breast cancer progression. MSc thesis in preparation, Université de Moncton 2011.
75. Birney, E.; Stamatoyannopoulos, J. A.; Dutta, A.; Guigo, R.; Gingeras, T. R.; Margulies, E. H.; Weng, Z.; Snyder, M.; Dermitzakis, E. T.; Thurman, R. E.; Kuehn, M. S.; Taylor, C. M.; Neph, S.; Koch, C. M.; Asthana, S.; Malhotra, A.; Adzhubei, I.; Greenbaum, J. A.; Andrews, R. M.; Flicek, P., et al., Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 2007, 447(7146), 799-816.
76. Robinson, M. D.; McCarthy, D. J.; Smyth, G. K., Edger: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics, 2010, 26(1), 139-140.
77. Eberhard, D.; Busslinger, M., The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. Cancer Res., 1999, 59(7 Suppl), 1716s-1724s; discussion 1724s-1725s.
78. Gyorffy, B.; Lanczky, A.; Eklund, A. C.; Denkert, C.; Budczies, J.; Li, Q.; Szallasi, Z., An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat., 2010, 123(3), 725-731.
79. van Nimwegen, M. J.; Verkoeijen, S.; van Buren, L.; Burg, D.; van de Water, B., Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer Res., 2005, 65(11), 4698-4706.
80. Schmidt, M.; Bohm, D.; von Torne, C.; Steiner, E.; Puhl, A.; Pilch, H.; Lehr, H. A.; Hengstler, J. G.; Kolbl, H.; Gehrmann, M., The humoral immune system has a key prognostic impact in nodenegative breast cancer. Cancer Res., 2008, 68(13), 5405-5413.
81. Gonzalez, L.; Agullo-Ortuno, M. T.; Garcia-Martinez, J. M.; Calcabrini, A.; Gamallo, C.; Palacios, J.; Aranda, A.; Martin-Perez, J., Role of c-Src in human MCF7 breast cancer cell tumorigenesis. J. Biol. Chem., 2006, 281(30), 20851-20864.
82. Franco, S.; Perrin, B.; Huttenlocher, A., Isoform specific function of calpain 2 in regulating membrane protrusion. Exp. Cell Res., 2004, 299(1), 179-187.
83. Calalb, M. B.; Polte, T. R.; Hanks, S. K., Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell Biol., 1995, 15(2), 954-963.
84. Glading, A.; Lauffenburger, D. A.; Wells, A., Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol., 2002, 12(1), 46-54.
85. Goll, D. E.; Thompson, V. F.; Li, H.; Wei, W.; Cong, J., The calpain system. Physiol. Rev., 2003, 83(3), 731-801.
86. Howe, A. K., Regulation of actin-based cell migration by cAMP/PKA. Biochim. Biophys. Acta, 2004, 1692(2-3), 159-174.
87. Ridley, A. J.; Schwartz, M. A.; Burridge, K.; Firtel, R. A.; Ginsberg, M. H.; Borisy, G.; Parsons, J. T.; Horwitz, A. R., Cell migration: integrating signals from front to back. Science 2003, 302, (5651), 1704-9.
88. Chang, L.; Goldman, R. D., Intermediate filaments mediate cytoskeletal crosstalk. Nat. Rev. Mol. Cell Biol., 2004, 5(8), 601-613.
89. Zaidel-Bar, R.; Cohen, M.; Addadi, L.; Geiger, B., Hierarchical assembly of cell-matrix adhesion complexes. Biochem. Soc. Trans., 2004, 32(Pt3), 416-420.
90. Carragher, N. O.; Westhoff, M. A.; Fincham, V. J.; Schaller, M. D.; Frame, M. C., A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr. Biol., 2003, 13(16), 1442-1450.
91. Chan, K. T.; Bennin, D. A.; Huttenlocher, A., Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J. Biol. Chem., 2010, 285(15), 11418-11426.