Intracellular trafficking of polyamidoamine-poly(ethylene glycol) block copolymers in DNA delivery

Bioconjugate Chemistry

Volumn 22, Issue 8, 2011, Pages 1519-1525

  Bonner, Daniel K ^a,b,c   Leung, Cheuk ^a   Chen Liang, Jane ^a   Chingozha, Loice ^a   Langer, Robert ^a,b,c   Hammond, Paula T ^a,b  

^a USA   (United States)

^b David H Koch Institute for Integrative Cancer Research at MIT   (United States)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; EFFICIENCY; GENE TRANSFER; GENES; NUCLEIC ACIDS; POLYETHYLENE GLYCOLS; THROUGHPUT;

BLOCK CO POLYMERS; DELIVERY SYSTEMS; DNA DELIVERY; ENDOSOMAL ESCAPES; IMMUNOGENICITY; INTRACELLULAR TRAFFICKING; MODULARS; POLYAMIDOAMINES; SYNTHETIC VECTOR; TRANSFECTION EFFICIENCY;

BLOCK COPOLYMERS;

COPOLYMER; DNA; LIGAND; MACROGOL; PLASMA PROTEIN; POLYAMIDOAMINE;

ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DENDRITIC CELL; ENDOSOME; GENE TARGETING; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; VIRAL GENE DELIVERY SYSTEM;

EID: 80051715739     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200059v     Document Type: Article

References (42)

1. Somia, N. and Verma, I. M. (2000) Gene therapy: trials and tribulations Nat. Rev. Genet. 1, 91-99
2. Schaffert, D. and Wagner, E. (2008) Gene therapy progress and prospects: synthetic polymer-based systems Gene Ther. 15, 1131-8
3. Walther, W. and Stein, U. (2000) Viral vectors for gene transfer-A review of their use in the treatment of human diseases Drugs 60, 249-271
4. Zaiss, A. K. and Muruve, D. A. (2008) Immunity to adeno-associated virus vectors in animals and humans: a continued challenge Gene Ther. 15, 808-816 (Pubitemid 351712613)
5. Nayak, S. and Herzog, R. W. (2010) Progress and prospects: immune responses to viral vectors Gene Ther. 17, 295-304
6. Glover, D. J., Lipps, H. J., and Jans, D. A. (2005) Towards safe, nonviral therapeutic gene expression in humans Nat. Rev. Genet. 6, 299-310 (Pubitemid 40469049)
7. Kan, P. L., Schatzlein, A. G., and Uchegbu, I. F. (2006) Polymers used for the delivery of genes in gene therapy, in Polymers in drug delivery (Uchegbu, I. F. and Schatzlein, A. G., Eds.) CRC Press, Boca Raton.
8. Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., and Danielsen, M. (1987) Lipofection-a highly efficient, lipid-mediated dna-transfection procedure Proc. Natl. Acad. Sci. U. S. A. 84, 7413-7417
9. Kogure, K., Akita, H., Yamada, Y., and Harashima, H. (2008) Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system Adv. Drug Delivery Rev. 60, 559-571 (Pubitemid 351215573)
10. Legendre, J.-Y. and Szoka, F. C., Jr. (1992) Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes Pharm. Res. 9, 1235-1242
11. Haensler, J. and Szoka, F. C. (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture Bioconjugate Chem. 4, 372-379
12. Tang, M. X., Redemann, C. T., and Szoka, F. C. (1996) In vitro gene delivery by degraded polyamidoamine dendrimers Bioconjugate Chem. 7, 703-714 (Pubitemid 27012712)
13. Abdallah, B., Hassan, A., Benoist, C., Goula, D., Behr, J. P., and Demeneix, B. A. (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine Hum. Gene Ther. 7, 1947-1954 (Pubitemid 26390233)
14. Anderson, D. G., Akinc, A., Hossain, N., and Langer, R. (2005) Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters) Mol. Ther. 11, 426-34 (Pubitemid 40277319)
15. Anderson, D. G., Lynn, D. M., and Langer, R. (2003) Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery Angew. Chem., Int. Ed. Engl. 42, 3153-8 (Pubitemid 36898737)
16. Lynn, D. M., Anderson, D. G., Putnam, D., and Langer, R. (2001) Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library J. Am. Chem. Soc. 123, 8155-6 (Pubitemid 32895758)
17. Fukushima, S., Miyata, K., Nishiyama, N., Kanayama, N., Yamasaki, Y., and Kataoka, K. (2005) PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery J. Am. Chem. Soc. 127, 2810-2811 (Pubitemid 40349832)
18. Chiou, H. C., Tangco, M. V., Levine, S. M., Robertson, D., Kormis, K., Wu, C. H., and Wu, G. Y. (1994) Enhanced resistance to nuclease degradation of nucleic-acids complexed to asialoglycoprotein-polylysine carriers Nucleic Acids Res. 22, 5439-5446
19. Dash, P. R., Read, M. L., Barrett, L. B., Wolfert, M., and Seymour, L. W. (1999) Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery Gene Ther. 6, 643-650 (Pubitemid 29192673)
20. Patel, H. M. (1992) Serum opsonins and liposomes: their interaction and opsonophagocytosis Crit. Rev. Ther. Drug Carrier Syst. 9, 39-90
21. Mislick, K. A. and Baldeschwieler, J. D. (1996) Evidence for the role of proteoglycans in cation-mediated gene transfer Proc. Natl. Acad. Sci. U. S. A. 93, 12349-12354 (Pubitemid 26367146)
22. Lam, A. P. and Dean, D. A. (2010) Progress and prospects: nuclear import of nonviral vectors Gene Ther. 1-9
23. Dean, D. A., Strong, D. D., and Zimmer, W. E. (2005) Nuclear entry of nonviral vectors Gene Ther. 12, 881-90 (Pubitemid 40852206)
24. Hama, S., Akita, H., Iida, S., Mizuguchi, H., and Harashima, H. (2007) Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex Nucleic Acids Res. 35, 1533-43 (Pubitemid 46592875)
25. Wood, K. C., Little, S. R., Langer, R., and Hammond, P. T. (2005) A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery Angew. Chem., Int. Ed. 44, 6704-8 (Pubitemid 41532216)
26. Wood, K. C., Azarin, S. M., Arap, W., Pasqualini, R., Langer, R., and Hammond, P. T. (2008) Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide Bioconjugate Chem. 19, 403-5 (Pubitemid 351294909)
27. Arap, M. A., Lahdenranta, J., Mintz, P. J., Hajitou, A., Arap, W., and Pasqualini, R. (2004) Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands Cancer Cell 6, 275-284 (Pubitemid 39222040)
28. Lee, A. S. (2007) GRP78 induction in cancer: therapeutic and prognostic implications Cancer Res. 67, 3496-3499 (Pubitemid 46762126)
29. Li, J. and Lee, A. S. (2006) Stress induction of GRP78/BiP and its role in cancer Current 45-54
30. Gabrielson, N. P. and Pack, D. W. (2006) Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions Biomacromolecules 7, 2427-2435 (Pubitemid 44336356)
31. Forrest, M. L., Meister, G., Koerber, J., and Pack, D. (2004) Partial acetylation of polyethylenimine enhances in vitro gene delivery Pharm. Res. 21, 365-371 (Pubitemid 38221984)
32. Sahay, G., Alakhova, D. Y., and Kabanov, A. V. Endocytosis of nanomedicines. J. Controlled Release 145, 182-195.
33. Giri, J., Diallo, M. S., Simpson, A. J., Liu, Y., Goddard, W. A., Kumar, R., and Woods, G. C. Interactions of poly(amidoamine) dendrimers with human serum albumin: binding constants and mechanisms. ACS Nano [Online early Online].
34. Ni, M., Zhang, Y., and Lee, A. S. (2011) Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting Biochem. J. 434, 181-8
35. Payne, C. K. (2007) Imaging gene delivery with fluorescence microscopy Nanomedicine 2, 847-60
36. Akita, H., Ito, R., Khalil, I. A., Futaki, S., and Harashima, H. (2004) Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy Mol. Ther. 9, 443-451 (Pubitemid 38404534)
37. Akinc, A., Thomas, M., Klibanov, A. M., and Langer, R. (2005) Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis J. Gene Med. 7, 657-63 (Pubitemid 40744532)
38. Hu, Y., Litwin, T., Nagaraja, A. R., Kwong, B., Katz, J., Watson, N., and Irvine, D. J. (2007) Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles Nano Lett. 7, 3056-3064 (Pubitemid 350132930)
39. Jones, R. A., Cheung, C. Y., Black, F. E., Zia, J. K., Stayton, P. S., Hoffman, A. S., and Wilson, M. R. (2003) Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles Biochem. J. 372, 65-75 (Pubitemid 36609607)
40. Barua, S. and Rege, K. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials 31, 5894-5902.
41. Pouton, C. W., Wagstaff, K. M., Roth, D. M., Moseley, G. W., and Jans, D. A. (2007) Targeted delivery to the nucleus Adv. Drug Delivery Rev. 59, 698-717 (Pubitemid 47320817)
42. Bielinska, A. U., Kukowska-Latallo, J. F., and Baker, J. R. (1997) The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA Biochim. Biophys. Acta 1353, 180-190 (Pubitemid 27360174)