Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

Current Topics in Medicinal Chemistry

Volumn 11, Issue 16, 2011, Pages 2048-2059

  Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antimicrobial drug discovery; Isoprenoid precursor biosynthesis; Malaria; Structure based inhibitor discovery; Toxoplasmosis

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE SYNTHASE; 1 HYDROXY 2 METHYL 2 BUTENYL 4 DIPHOSPHATE REDUCTASE; 1 HYDROXY 2 METHYL 2 BUTENYL 4 DIPHOSPHATE SYNTHASE; 2C METHYL DEXTRO ERYTHRITOL 2,4 CYCLODIPHOSPHATE SYNTHASE; 4 DIPHOSPHOCYTIDYL 2C METHYL DEXTRO ERYTHRITOL CYTIDYLYLTRANSFERASE; 4 DIPHOSPHOCYTIDYL 2C METHYL DEXTRO ERYTHRITOL KINASE; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; BACTERIAL ENZYME; DIMETHYLALLYL DIPHOSPHATE; FOSMIDOMYCIN; ISOPENTENYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; ISOPRENOID; MEVALONIC ACID; PYROPHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APICOMPLEXA; APICOMPLEXAN INFECTION; ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; DRUG BINDING SITE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GRAM NEGATIVE BACTERIUM; MALARIA; NONHUMAN; PLASMODIUM; SEQUENCE ALIGNMENT;

ANIMALS; ANTIPROTOZOAL AGENTS; APICOMPLEXA; BACTERIA; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; ENZYME INHIBITORS; ENZYME PRECURSORS; ESCHERICHIA COLI PROTEINS; FOSFOMYCIN; HEMITERPENES; HUMANS; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTOZOAN INFECTIONS; PROTOZOAN PROTEINS; TERPENES;

EID: 80051674818     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802611796575867     Document Type: Article

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