Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

ChemMedChem

Volumn 3, Issue 1, 2008, Pages 91-101

  Crane, Christine M ^a   Hirsch, Anna K H ^a   Alphey, Magnus S ^b   Sgraja, Tanja ^b   Lauw, Susan ^c   Illarionova, Victoria ^c   Rohdich, Felix ^c   Eisenreich, Wolfgang ^c   Hunter, William N ^b   Bacher, Adelbert ^c   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Crystal structure analysis; Drug design; Inhibitors; Kinases; Non mevalonate pathway

Indexed keywords

CYTIDINE; DRUG DERIVATIVE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; ISPE PROTEIN, E COLI; MEVALONIC ACID; PHENYLALANINE; PHOSPHOTRANSFERASE; TERPENE;

ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; HYDROPHOBICITY; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTIDINE; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HUMANS; HYDROPHOBICITY; MEVALONIC ACID; MYCOBACTERIUM TUBERCULOSIS; PHENYLALANINE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLASMODIUM FALCIPARUM; TERPENES;

EID: 44349094544     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700208     Document Type: Article

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