Biosynthesis of terpenoids 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum

European Journal of Biochemistry

Volumn 268, Issue 11, 2001, Pages 3190-3197

  Rohdich, Felix ^a   Eisenreich, Wolfgang ^a   Wungsintaweekul, Juraithip ^a   Hecht, Stefan ^a   Schuhr, Christoph A ^a   Bacher, Adelbert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

2C methyl D erythritol 2,4 cyclodiphosphate; Isoprenoid biosynthesis; Malaria; Nonmevalonate pathway; Plasmodium falciparum

Indexed keywords

2 C METHYL DEXTRO ERYTHRITOL 2,4 CYCLODIPHOSPHATE; 2 C METHYL DEXTRO ERYTHRITOL 2,4 CYCLODIPHOSPHATE SYNTHASE; MAGNESIUM ION; MANGANESE; RECOMBINANT ENZYME; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PH; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CLONING, MOLECULAR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHORUS-OXYGEN LYASES; PLASMIDS; PLASMODIUM FALCIPARUM; TERPENES;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034845931     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02204.x     Document Type: Article

References (34)

1. Creating isorenoid diversity
2. Conversion of acetyl-coenzyme A to isopentenyl pyrophosphate
3. Sterol molecule: Structure, biosynthesis and function
4. Some aspects of isoprenoid biosynthesis in plants. A review
5. Biosynthesis of mevalonic acid from acetyl-CoA
6. Isoprenoid biosynthesis in bacteria: A novel pathway for the early steps leading to isopentenyl diphosphate
7. The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms
8. The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
9. Ginkgolide biosynthesis
10. The 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis in plants
11. Stable iostope studies on the biosynthesis of the thiazole moiety of thiamin in Escherichia coli
12. 1-Deoxy-D-threo-2-pentulose: The precursor of the five-carbon chain of the thiazole of thiamine
13. 6: Incorporation of D-1-deoxyxylulose
14. Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis
15. Identification of a thiamin-dependent synthase in Escherichia coli reqired for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoid, thiamin, and pyridoxol
16. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursur for isoprenoid, thiamin, and pyridoxol biosynthesis
17. Biosynthesis of terpenoids: YgbB protein converts of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
18. Studies on the nonmevalonate pathway: Formation 2C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2C-methyl-D-erythritol
19. MicroReview: The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways
20. A gene cluster for the mevalonate pathway from Streptomyces sp. strain CL190
21. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis
22. Evidence for the shikimate pathway in apicomplexan parasites
23. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
24. Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol
25. Biosynthesis of isoprenoids. A rapid method for the preparation of isotope-labeled 4-diphosphocytidyl-2C-methyl-D-erythritol
26. DNA sequencing with chain-terminating inhibitors. 1977
27. XL1-Blue: A high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection
28. Biosynthesis of 2C-methyl-D-erythritol in plants by rearrangement of the terpenoid precursor, 1-deoxy-D-xylulose 5-phosphate
29. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
30. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
31. The plastid in apicomplexa: What use is it?
32. Carotenoid biosynthesis during tomato fruit development: Regulatory role of 1-deoxy-D-xylulose 5-phosphate synthase