FKBP38-Bcl-2 interaction: A novel link to chemoresistance

Current Opinion in Pharmacology

Volumn 11, Issue 4, 2011, Pages 354-359

  Choi, Bo Hwa ^a   Yoon, Ho Sup ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIMYCIN; CALCINEURIN; CISPLATIN; CYCLOHEXIMIDE; DM CHX; DOXORUBICIN; ETOPOSIDE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 38; FK 506 BINDING PROTEIN 51; FK 506 BINDING PROTEIN 52; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; ISOMERASE INHIBITOR; KINETIN RIBOSIDE; MAMMALIAN TARGET OF RAPAMYCIN; MELPHALAN; MINERALOCORTICOID RECEPTOR; PACLITAXEL; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; RHEB PROTEIN; STAUROSPORINE; TACROLIMUS; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CARCINOGENESIS; CELL SURVIVAL; COLON CANCER; COMPLEX FORMATION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG SENSITIVITY; HUMAN; LIVER CANCER; LUNG CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STOMACH CANCER; ULTRAVIOLET RADIATION;

EID: 80051666034     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2011.04.013     Document Type: Review

References (48)

1. B.K. Law, A. Chytil, N. Dumont, E.G. Hamilton, M.E. Waltner-Law, M.E. Aakre, C. Covington, and H.L. Moses Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells Mol Cell Biol 22 2002 8184 8198 (Pubitemid 35304052)
2. C.K. Yip, K. Murata, T. Walz, D.M. Sabatini, and S.A. Kang Structure of the human mTOR complex 1 and its implications for rapamycin inhibition Mol Cell 38 2010 768 774
3. X. Bai, D. Ma, A. Liu, X. Shen, Q.J. Wang, Y. Liu, and Y. Jiang Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38 Science 318 2007 977 980 (Pubitemid 350098994)
4. D.D. Sarbassov, S.M. Ali, S. Sengupta, J.H. Sheen, P.P. Hsu, A.F. Bagley, A.L. Markhard, and D.M. Sabatini Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB Mol Cell 22 2006 159 168
5. H. Pei, L. Li, B.L. Fridley, G.D. Jenkins, K.R. Kalari, W. Lingle, G. Petersen, Z. Lou, and L. Wang FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt Cancer Cell 16 2009 259 266
6. L. Li, B. Fridley, K. Kalari, G. Jenkins, A. Batzler, S. Safgren, M. Hildebrandt, M. Ames, D. Schaid, and L. Wang Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression Cancer Res 68 2008 7050 7058
7. B.H. Choi, L. Feng, and H.S. Yoon FKBP38 protects Bcl-2 from caspase-dependent degradation J Biol Chem 285 2010 9770 9779
8. A.S. Azmi, Z. Wang, P.A. Philip, R.M. Mohammad, and F.H. Sarkar Emerging Bcl-2 inhibitors for the treatment of cancer Expert Opin Emerg Drugs 16 2011 59 70
9. C.B. Kang, Y. Hong, S. Dhe-Paganon, and H.S. Yoon FKBP family proteins: immunophilins with versatile biological functions Neurosignals 16 2008 318 325
10. C.B. Kang, L. Feng, J. Chia, and H.S. Yoon Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2 Biochem Biophys Res Commun 337 2005 30 38 (Pubitemid 41393754)
11. F. Edlich, F. Erdmann, F. Jarczowski, M.C. Moutty, M. Weiwad, and G. Fischer The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90 J Biol Chem 282 2007 15341 15348 (Pubitemid 47093293)
12. R. Alag, N. Bharatham, A. Dong, T. Hills, A. Harikishore, A.A. Widjaja, S.G. Shochat, R. Hui, and H.S. Yoon Crystallographic structure of the tetratricopeptide repeat domain of plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 c-terminal pentapeptide Protein Sci 18 2009 2115 2124
13. C. Scheufler, A. Brinker, G. Bourenkov, S. Pegoraro, L. Moroder, H. Bartunik, F.U. Hartl, and I. Moarefi Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine Cell 101 2000 199 210 (Pubitemid 32004747)
14. J.P. Schulke, G.M. Wochnik, I. Lang-Rollin, N.C. Gassen, R.T. Knapp, B. Berning, A. Yassouridis, and T. Rein Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors PLoS ONE 5 2010 e11717
15. M.D. Galigniana, A.G. Erlejman, M. Monte, C. Gomez-Sanchez, and G. Piwien-Pilipuk The Hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events Mol Cell Biol 30 2010 1285 1298
16. P.C. Echeverria, G. Mazaira, A. Erlejman, C. Gomez-Sanchez, G. Piwien Pilipuk, and M.D. Galigniana Nuclear import of the glucocorticoid receptor-Hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta Mol Cell Biol 29 2009 4788 4797
17. G.M. Wochnik, J. Ruegg, G.A. Abel, U. Schmidt, F. Holsboer, and T. Rein FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells J Biol Chem 280 2005 4609 4616 (Pubitemid 40288629)
18. U.K. Jinwal, J. Koren 3rd, S.I. Borysov, A.B. Schmid, J.F. Abisambra, L.J. Blair, A.G. Johnson, J.R. Jones, C.L. Shults, and J.C. O'Leary 3rd The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules J Neurosci 30 2010 591 599
19. S. Periyasamy, T. Hinds Jr., L. Shemshedini, W. Shou, and E.R. Sanchez FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A Oncogene 29 2010 1691 1701
20. L. Ni, C.S. Yang, D. Gioeli, H. Frierson, D.O. Toft, and B.M. Paschal FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells Mol Cell Biol 30 2010 1243 1253
21. M. Shirane, and K.I. Nakayama Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis Nat Cell Biol 5 2003 28 37 (Pubitemid 36054326)
22. H.Q. Wang, Y. Nakaya, Z. Du, T. Yamane, M. Shirane, T. Kudo, M. Takeda, K. Takebayashi, Y. Noda, K.I. Nakayama, and M. Nishimura Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2 Hum Mol Genet 14 2005 1889 1902 (Pubitemid 41418059)
23. F. Erdmann, F. Jarczowski, M. Weiwad, G. Fischer, and F. Edlich Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells FEBS Lett 581 2007 5709 5714 (Pubitemid 350182414)
24. S.W. Muchmore, M. Sattler, H. Liang, R.P. Meadows, J.E. Harlan, H.S. Yoon, D. Nettesheim, B.S. Chang, C.B. Thompson, and S.L. Wong X-ray and NMR structure of human Bcl-xl, an inhibitor of programmed cell death Nature 381 1996 335 341
25. C.B. Kang, J. Tai, J. Chia, and H.S. Yoon The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK506 binding protein 38 (FKBP38) FEBS Lett 579 2005 1469 1476 (Pubitemid 40289198)
26. F. Edlich, M. Weiwad, F. Erdmann, J. Fanghanel, F. Jarczowski, J.U. Rahfeld, and G. Fischer Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin EMBO J 24 2005 2688 2699 (Pubitemid 41076324)
27. L. Peng, D. Liang, W. Tong, J. Li, and Z. Yuan Hepatitis c virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR J Biol Chem 285 2010 20870 20881
28. D. Ma, X. Bai, S. Guo, and Y. Jiang The switch 1 region of Rheb is critical for its interaction with FKBP38 J Biol Chem 283 2008 25963 25970
29. D. Ma, X. Bai, H. Zou, Y. Lai, and Y. Jiang Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-xl J Biol Chem 285 2010 8621 8627
30. F. Edlich, M. Weiwad, D. Wildemann, F. Jarczowski, S. Kilka, M.C. Moutty, G. Jahreis, C. Lucke, W. Schmidt, F. Striggow, and G. Fischer The specific FKBP38 inhibitor n-(n',n'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia J Biol Chem 281 2006 14961 14970 (Pubitemid 43855200)
31. P. Chaudhry, and E. Asselin Resistance to chemotherapy and hormone therapy in endometrial cancer Endocr Relat Cancer 16 2009 363 380
32. F.J. Sharom ABC multidrug transporters: structure, function and role in chemoresistance Pharmacogenomics 9 2008 105 127 (Pubitemid 351560534)
33. X.K. Yang, F. Zheng, J.H. Chen, Q.L. Gao, Y.P. Lu, S.X. Wang, C.Y. Wang, and D. Ma Relationship between expression of apoptosis-associated proteins and caspase-3 activity in cisplatin-resistant human ovarian cancer cell line Ai Zheng 21 2002 1288 1291
34. Y. Sagawa, A. Fujitoh, H. Nishi, H. Ito, T. Yudate, and K. Isaka Establishment of three cisplatin-resistant endometrial cancer cell lines using two methods of cisplatin exposure Tumour Biol 32 2011 399 408
35. Y. Tabuchi, J. Matsuoka, M. Gunduz, T. Imada, R. Ono, M. Ito, T. Motoki, T. Yamatsuji, Y. Shirakawa, and M. Takaoka Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer Int J Oncol 34 2009 313 319
36. L.K. Leung, and T.T. Wang Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7 Breast Cancer Res Treat 55 1999 73 83 (Pubitemid 29353976)
37. G. Tudor, A. Aguilera, D.O. Halverson, N.D. Laing, and E.A. Sausville Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xl protein levels Cell Death Differ 7 2000 574 586 (Pubitemid 30303613)
38. Y. Zhao, C.L. Zhang, B.F. Zeng, X.S. Wu, T.T. Gao, and Y. Oda Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing Biochem Biophys Res Commun 390 2009 642 647
39. M.D. Hadjidaniel, and C.P. Reynolds Antagonism of cytotoxic chemotherapy in neuroblastoma cell lines by 13-cis-retinoic acid is mediated by the antiapoptotic Bcl-2 family proteins Mol Cancer Ther 9 2010 3164 3174
40. P. Chanvorachote, U. Nimmannit, C. Stehlik, L. Wang, B.H. Jiang, B. Ongpipatanakul, and Y. Rojanasakul Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination Cancer Res 66 2006 6353 6360
41. N. Azad, A. Iyer, V. Vallyathan, L. Wang, V. Castranova, C. Stehlik, and Y. Rojanasakul Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation Ann N Y Acad Sci 1203 2010 1 6
42. J. Zhang, H. Yan, Y.P. Wu, C. Li, and G.Y. Zhang Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment J Biol Chem 286 2011 7669 7680
43. S. Barth, J. Nesper, P.A. Hasgall, R. Wirthner, K.J. Nytko, F. Edlich, D.M. Katschinski, D.P. Stiehl, R.H. Wenger, and G. Camenisch The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability Mol Cell Biol 27 2007 3758 3768 (Pubitemid 46726183)
44. S. Barth, F. Edlich, U. Berchner-Pfannschmidt, S. Gneuss, G. Jahreis, P.A. Hasgall, J. Fandrey, R.H. Wenger, and G. Camenisch Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38 J Biol Chem 284 2009 23046 23058
45. T. Nakagawa, M. Shirane, S. Iemura, T. Natsume, and K.I. Nakayama Anchoring of the 26s proteasome to the organellar membrane by FKBP38 Genes Cells 12 2007 709 719 (Pubitemid 46952545)
46. S. Fong, L. Mounkes, Y. Liu, M. Maibaum, E. Alonzo, P.Y. Desprez, A.D. Thor, M. Kashani-Sabet, and R.J. Debs Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family Proc Natl Acad Sci USA 100 2003 14253 14258 (Pubitemid 37499223)
47. S. Ma, T.K. Lee, B.J. Zheng, K.W. Chan, and X.Y. Guan CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway Oncogene 27 2008 1749 1758 (Pubitemid 351380265)
48. R. Di Fiore, A. Santulli, R.D. Ferrante, M. Giuliano, A. De Blasio, C. Messina, G. Pirozzi, V. Tirino, G. Tesoriere, and R. Vento Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment J Cell Physiol 219 2009 301 313