Functional network disruption in the degenerative dementias

The Lancet Neurology

Volumn 10, Issue 9, 2011, Pages 829-843

  Pievani, Michela ^a   de Haan, Willem ^b   Wu, Tao ^c   Seeley, William W ^d   Frisoni, Giovanni B ^a  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; DEMENTIA; DISEASE COURSE; ELECTROENCEPHALOGRAPHY; FRONTOTEMPORAL DEMENTIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; MAGNETOENCEPHALOGRAPHY; PRIORITY JOURNAL; REVIEW;

DEMENTIA; ELECTROENCEPHALOGRAPHY; HUMANS; MAGNETIC RESONANCE IMAGING; NERVE NET; NEURODEGENERATIVE DISEASES;

EID: 80051663721     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(11)70158-2     Document Type: Review

References (145)

1. Taylor JP, Hardy J, Fischbeck KH Toxic proteins in neurodegenerative disease. Science 2002, 296:1991-1995.
2. Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008, 131:1630-1645.
3. Whitwell JL, Josephs KA, Murray ME, et al. MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology 2008, 71:743-749.
4. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
5. Albert MS, Dekosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:270-279.
6. Seeley WW, Crawford R, Rascovsky K, et al. Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Arch Neurol 2008, 65:249-255.
7. Whitwell JL, Josephs KA Voxel-based morphometry and its application to movement disorders. Parkinsonism Relat Disord 2007, 13(suppl 3):S406-S416.
8. Whitwell JL, Weigand SD, Shiung MM, et al. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain 2007, 130:708-719.
9. Du AT, Schuff N, Kramer JH, et al. Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain 2007, 130:1159-1166.
10. Frisoni GB, Fox NC, Jack CR, Scheltens P, Thompson PM The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol 2010, 6:67-77.
11. Alladi S, Xuereb J, Bak T, et al. Focal cortical presentations of Alzheimer's disease. Brain 2007, 130:2636-2645.
12. Sporns O The human connectome: a complex network. Ann N Y Acad Sci 2011, 1224:109-125.
13. Stam CJ Use of magnetoencephalography (MEG) to study functional brain networks in neurodegenerative disorders. J Neurol Sci 2010, 289:128-134.
14. Bullmore E, Sporns O Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 2009, 10:186-198.
15. Zhang D, Raichle ME Disease and the brain's dark energy. Nat Rev Neurol 2010, 6:15-28.
16. Sperling RA, Dickerson BC, Pihlajamaki M, et al. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med 2010, 12:27-43.
17. Bokde AL, Ewers M, Hampel H Assessing neuronal networks: understanding Alzheimer's disease. Prog Neurobiol 2009, 89:125-133.
18. Sorg C, Riedl V, Perneczky R, Kurz A, Wohlschläger AM Impact of Alzheimer's disease on the functional connectivity of spontaneous brain activity. Curr Alzheimer Res 2009, 6:541-553.
19. Dickerson BC, Sperling RA Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol 2009, 21:63-75.
20. Guye M, Bettus G, Bartolomei F, Cozzone PJ Graph theoretical analysis of structural and functional connectivity MRI in normal and pathological brain networks. MAGMA 2010, 23:409-421.
21. Dickerson BC Advances in functional magnetic resonance imaging: technology and clinical applications. Neurotherapeutics 2007, 4:360-370.
22. He Y, Chen Z, Evans A Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease. J Neurosci 2008, 28:4756-4766.
23. Yao Z, Zhang Y, Lin L, Zhou Y, Xu C, Jiang T Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease. PLoS Comput Biol 2010, 6:e1001006. Alzheimer's Disease Neuroimaging Initiative.
24. Fox MD, Raichle ME Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 2007, 8:700-711.
25. Beckmann CF, DeLuca M, Devlin JT, Smith SM Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci 2005, 360:1001-1013.
26. Damoiseaux JS, Rombouts SA, Barkhof F, et al. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA 2006, 103:13848-13853.
27. Buckner RL, Andrews-Hanna JR, Schacter DL The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 2008, 1124:1-38.
28. Seeley WW, Menon V, Schatzberg AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 2007, 27:2349-2356.
29. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 2005, 102:9673-9678.
30. Smith SM, Fox PT, Miller KL, et al. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci USA 2009, 106:13040-13045.
31. Hampson M, Tokoglu F, Sun Z, et al. Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. Neuroimage 2006, 31:513-519.
32. Varela F, Lachaux JP, Rodriguez E, Martinerie J The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2001, 2:229-239.
33. Ioannides AA Magnetoencephalography as a research tool in neuroscience: state of the art. Neuroscientist 2006, 12:524-544.
34. Nunez PL, Srinivasan R, Westdorp AF, et al. EEG coherency: I-Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalogr Clin Neurophysiol 1997, 103:499-515.
35. Johansen-Berg H, Behrens TEJ Diffusion MRI: from quantitative measurement to in vivo neuroanatomy 2009, Elsevier, London.
36. Catani M, Thiebaut de Schotten M A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 2008, 44:1105-1132.
37. Reijneveld JC, Ponten SC, Berendse HW, Stam CJ The application of graph theoretical analysis to complex networks in the brain. Clin Neurophysiol 2007, 118:2317-2331.
38. Watts DJ, Strogatz SH Collective dynamics of 'small-world' networks. Nature 1998, 393:440-442.
39. Bassett DS, Bullmore E Small-world brain networks. Neuroscientist 2006, 12:512-523.
40. Ferrarini L, Veer IM, Baerends E, et al. Hierarchical functional modularity in the resting-state human brain. Hum Brain Mapp 2009, 30:2220-2231.
41. Power JD, Fair DA, Schlaggar BL, Petersen SE The development of human functional brain networks. Neuron 2010, 67:735-748.
42. Meunier D, Achard S, Morcom A, Bullmore E Age-related changes in modular organization of human brain functional networks. Neuroimage 2009, 44:715-723.
43. van den Heuvel MP, Stam CJ, Kahn RS, Hulshoff Pol HE Efficiency of functional brain networks and intellectual performance. J Neurosci 2009, 29:7619-7624.
44. Wen W, Zhu W, He Y, et al. Discrete neuroanatomical networks are associated with specific cognitive abilities in old age. J Neurosci 2011, 31:1204-1212.
45. Bosma I, Reijneveld JC, Klein M, et al. Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG. Nonlinear Biomed Phys 2009, 3:9.
46. Wang L, Yu C, Chen H, et al. Dynamic functional reorganization of the motor execution network after stroke. Brain 2010, 133:1224-1238.
47. Castellanos NP, Paúl N, Ordóñez VE, et al. Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury. Brain 2010, 133:2365-2381.
48. Ponten SC, Bartolomei F, Stam CJ Small-world networks and epilepsy: graph theoretical analysis of intracerebrally recorded mesial temporal lobe seizures. Clin Neurophysiol 2007, 118:918-927.
49. Alstott J, Breakspear M, Hagmann P, Cammoun L, Sporns O Modeling the impact of lesions in the human brain. PLoS Comput Biol 2009, 5:e1000408.
50. Delbeuck X, Van der Linden M, Collette F Alzheimer's disease as a disconnection syndrome?. Neuropsychol Rev 2003, 13:79-92.
51. Saper CB, Wainer BH, German DC Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease. Neuroscience 1987, 23:389-398.
52. Thal DR, Rüb U, Orantes M, Braak H Phases of Ab-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58:1791-1800.
53. Braak H, Braak E Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
54. Braak H, Del Tredici K The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol 2011, 121:171-181.
55. Mormino EC, Kluth JT, Madison CM, et al. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 2009, 132:1310-1323.
56. Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci 2009, 29:1860-1873.
57. Greicius MD, Srivastava G, Reiss AL, Menon V Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci USA 2004, 101:4637-4642.
58. Zhou J, Greicius MD, Gennatas ED, et al. Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain 2010, 133:1352-1367.
59. Zhang HY, Wang SJ, Liu B, et al. Resting brain connectivity: changes during the progress of Alzheimer disease. Radiology 2010, 256:598-606.
60. Wang L, Zang Y, He Y, et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI. Neuroimage 2006, 31:496-504.
61. Zhang HY, Wang SJ, Xing J, et al. Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease. Behav Brain Res 2009, 197:103-108.
62. Sorg C, Riedl V, Mühlau M, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci USA 2007, 104:18760-18765.
63. Qi Z, Wu X, Wang Z, et al. Impairment and compensation coexist in amnestic MCI default mode network. Neuroimage 2010, 50:48-55.
64. Gili T, Cercignani M, Serra L, et al. Regional brain atrophy and functional disconnection across Alzheimer's disease evolution. J Neurol Neurosurg Psychiatry 2011, 82:58-66.
65. Pievani M, Agosta F, Pagani E, et al. Assessment of white matter tract damage in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 2010, 31:1862-1875.
66. Zhang Y, Schuff N, Du AT, et al. White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain 2009, 132:2579-2592.
67. Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 2010, 133:529-539.
68. Sexton CE, Kalu UG, Filippini N, Mackay CE, Ebmeier KP A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 2010, published online July 7. 10.1016/j.neurobiolaging.2010.05.019.
69. Stam CJ, Montez T, Jones BF, et al. Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease. Clin Neurophysiol 2005, 116:708-715.
70. Babiloni C, Ferri R, Binetti G, et al. Fronto-parietal coupling of brain rhythms in mild cognitive impairment: a multicentric EEG study. Brain Res Bull 2006, 69:63-73.
71. Stam CJ, Jones BF, Manshanden I, et al. Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer's disease. Neuroimage 2006, 32:1335-1344.
72. Mantini D, Perrucci MG, Del Gratta C, Romani GL, Corbetta M Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci USA 2007, 104:13170-13175.
73. Jann K, Kottlow M, Dierks T, Boesch C, Koenig T Topographic electrophysiological signatures of FMRI Resting State Networks. PLoS One 2010, 5:e12945.
74. Petrella JR, Sheldon FC, Prince SE, Calhoun VD, Doraiswamy PM Default mode network connectivity in stable vs progressive mild cognitive impairment. Neurology 2011, 76:511-517.
75. Stam CJ, de Haan W, Daffertshofer A, et al. Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. Brain 2009, 132:213-224.
76. Supekar K, Menon V, Rubin D, Musen M, Greicius MD Network analysis of intrinsic functional brain connectivity in Alzheimer's disease. PloS Comput Biol 2008, 4:e1000100.
77. Sanz-Arigita EJ, Schoonheim MM, Damoiseaux JS, et al. Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity. PLoS One 2010, 5:e13788.
78. deHaan W, Pijnenburg YA, Strijers RL, et al. Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory. BMC Neurosci 2009, 10:101.
79. Lo CY, Wang PN, Chou KH, Wang J, He Y, Lin CP Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease. J Neurosci 2010, 30:16876-16885.
80. Mackenzie IR, Rademakers R, Neumann M TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol 2010, 9:995-1007.
81. Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011, 76:1006-1014.
82. Josephs KA, Hodges JR, Snowden JS, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol 2011, published online May 26. 10.1007/s00401-011-0839-6.
83. Rohrer JD, Geser F, Zhou J, et al. TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia. Neurology 2010, 75:2204-2211.
84. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD Neurodegenerative diseases target large-scale human brain networks. Neuron 2009, 62:42-52.
85. Seeley WW, Allman JM, Carlin DA, et al. Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution. Alzheimer Dis Assoc Disord 2007, 21:S50-S57.
86. Whitwell JL, Avula R, Senjem ML, et al. Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology 2010, 74:1279-1287.
87. Agosta F, Henry RG, Migliaccio R, et al. Language networks in semantic dementia. Brain 2010, 133:286-299.
88. Pijnenburg YA, Strijers RL, Made YV, van der Flier WM, Scheltens P, Stam CJ Investigation of resting-state EEG functional connectivity in frontotemporal lobar degeneration. Clin Neurophysiol 2008, 119:1732-1738.
89. Rubinov M, Sporns O Complex network measures of brain connectivity: uses and interpretations. Neuroimage 2010, 52:1059-1069.
90. Whitwell JL, Jack CR, Parisi JE, et al. Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia. J Mol Neurosci 2011, published online May 10. 10.1007/s12031-011-9533-3.
91. Josephs KA, Whitwell JL, Knopman DS, et al. Two distinct subtypes of right temporal variant frontotemporal dementia. Neurology 2009, 73:1443-1450.
92. Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003, 24:197-211.
93. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005, 65:1863-1872.
94. Alexander GE, DeLong MR, Strick PL Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986, 9:357-381.
95. Wu T, Long X, Wang L, et al. Functional connectivity of cortical motor areas in the resting state in Parkinson's disease. Hum Brain Mapp 2010, published online Aug 25. 10.1002/hbm.21118.
96. Helmich RC, Derikx LC, Bakker M, Scheeringa R, Bloem BR, Toni I Spatial remapping of cortico-striatal connectivity in Parkinson's disease. Cereb Cortex 2010, 20:1175-1186.
97. Baudrexel S, Witte T, Seifried C, et al. Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease. Neuroimage 2011, 55:1728-1738.
98. Kwak Y, Peltier S, Bohnen NI, Müller ML, Dayalu P, Seidler RD Altered resting state cortico-striatal connectivity in mild to moderate stage Parkinson's disease. Front Syst Neurosci 2010, 4:143.
99. Litvak V, Jha A, Eusebio A, et al. Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. Brain 2011, 134:359-374.
100. Silberstein P, Pogosyan A, Kühn AA, et al. Cortico-cortical coupling in Parkinson's disease and its modulation by therapy. Brain 2005, 128:1277-1291.
101. Stoffers D, Bosboom JL, Deijen JB, Wolters ECh, Stam CJ, Berendse HW Increased cortico-cortical functional connectivity in early-stage Parkinson's disease: an MEG study. Neuroimage 2008, 41:212-222.
102. Bosboom JL, Stoffers D, Wolters ECh, Stam CJ, Berendse HW MEG resting state functional connectivity in Parkinson's disease related dementia. J Neural Transm 2009, 116:193-202.
103. Franciotti R, Iacono D, Della Penna S, et al. Cortical rhythms reactivity in AD, LBD and normal subjects: a quantitative MEG study. Neurobiol Aging 2006, 27:1100-1109.
104. Andersson M, Hansson O, Minthon L, Rosén I, Londos E Electroencephalogram variability in dementia with lewy bodies, Alzheimer's disease and controls. Dement Geriatr Cogn Disord 2008, 26:284-290.
105. Kai T, Asai Y, Sakuma K, Koeda T, Nakashima K Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer's disease. J Neurol Sci 2005, 237:89-95.
106. Galvin JE, Price JL, Yan Z, Morris JC, Sheline YI Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease. Neurology 2011, 76:1797-1803.
107. Péran P, Cherubini A, Assogna F, et al. Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. Brain 2010, 133:3423-3433.
108. Vaillancourt DE, Spraker MB, Prodoehl J, et al. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 2009, 72:1378-1384.
109. Yoshikawa K, Nakata Y, Yamada K, Nakagawa M Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI. J Neurol Neurosurg Psychiatry 2004, 75:481-484.
110. Menke RA, Scholz J, Miller KL, et al. MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. Neuroimage 2009, 47:435-441.
111. Gattellaro G, Minati L, Grisoli M, et al. White matter involvement in idiopathic Parkinson disease: a diffusion tensor imaging study. AJNR Am J Neuroradiol 2009, 30:1222-1226.
112. Karagulle Kendi AT, Lehericy S, Luciana M, Ugurbil K, Tuite P Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol 2008, 29:501-505.
113. Zhang K, Yu C, Zhang Y, et al. Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease. Eur J Radiol 2011, 77:269-273.
114. Lee JE, Park HJ, Park B, et al. A comparative analysis of cognitive profiles and white-matter alterations using voxel-based diffusion tensor imaging between patients with Parkinson's disease dementia and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 2010, 81:320-326.
115. Matsui H, Nishinaka K, Oda M, Niikawa H, Kubori T, Udaka F Dementia in Parkinson's disease: diffusion tensor imaging. Acta Neurol Scand 2007, 116:177-181.
116. Kantarci K, Avula R, Senjem ML, et al. Dementia with Lewy bodies and Alzheimer disease: neurodegenerative patterns characterized by DTI. Neurology 2010, 74:1814-1821.
117. Ota M, Sato N, Ogawa M, et al. Degeneration of dementia with Lewy bodies measured by diffusion tensor imaging. NMR Biomed 2009, 22:280-284.
118. Kiuchi K, Morikawa M, Taoka T, et al. White matter changes in dementia with Lewy bodies and Alzheimer's disease: a tractography-based study. J Psychiatr Res 2011, published online Feb 9. 10.1016/j.jpsychires.2011.01.011.
119. Burack MA, Hartlein J, Flores HP, Taylor-Reinwald L, Perlmutter JS, Cairns NJ In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology 2010, 74:77-84.
120. Wu T, Wang L, Chen Y, Zhao C, Li K, Chan P Changes of functional connectivity of the motor network in the resting state in Parkinson's disease. Neurosci Lett 2009, 460:6-10.
121. Skidmore F, Korenkevych D, Liu Y, He G, Bullmore E, Pardalos PM Connectivity brain networks based on wavelet correlation analysis in Parkinson fMRI data. Neurosci Lett 2011, 499:47-51.
122. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL Functional-anatomic fractionation of the brain's default network. Neuron 2010, 65:550-562.
123. Robinson S, Basso G, Soldati N, et al. A resting state network in the motor control circuit of the basal ganglia. BMC Neurosci 2009, 10:137.
124. Gomperts SN, Rentz DM, Moran E, et al. Imaging amyloid deposition in Lewy body diseases. Neurology 2008, 71:903-910.
125. Achard S, Salvador R, Whitcher B, Suckling J, Bullmore E A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci 2006, 26:63-72.
126. Mesulam MM From sensation to cognition. Brain 1998, 121:1013-1052.
127. Frost B, Diamond MI Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci 2010, 11:155-159.
128. Clavaguera F, Bolmont T, Crowther RA, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 2009, 11:909-913.
129. Eisele YS, Obermüller U, Heilbronner G, et al. Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 2010, 330:980-982.
130. Angot E, Steiner JA, Hansen C, Li JY, Brundin P Are synucleinopathies prion-like disorders?. Lancet Neurol 2010, 9:1128-1138.
131. Palop JJ, Chin J, Roberson ED, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007, 55:697-711.
132. Wu C, Cui B, He L, Chen L, Mobley WC The coming of age of axonal neurotrophin signaling endosomes. J Proteomics 2009, 72:46-55.
133. Mesulam MM Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles. Neuron 1999, 24:521-529.
134. Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005, 25:7709-7717.
135. Cole DM, Smith SM, Beckmann CF Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Front Syst Neurosci 2010, 4:8.
136. Zuo XN, Kelly C, Adelstein JS, Klein DF, Castellanos FX, Milham MP Reliable intrinsic connectivity networks: test-retest evaluation using ICA and dual regression approach. Neuroimage 2010, 49:2163-2177.
137. Stevenson IH, Körding KP On the similarity of functional connectivity between neurons estimated across timescales. PLoS One 2010, 5:e9206.
138. Wu X, Li R, Fleisher AS, et al. Altered default mode network connectivity in Alzheimer's disease-a resting functional MRI and bayesian network study. Hum Brain Mapp 2011, published online Jan 21. 10.1002/hbm.21153.
139. Honey CJ, Sporns O, Cammoun L, et al. Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci USA 2009, 106:2035-2040.
140. Damoiseaux JS, Greicius MD Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct 2009, 213:525-533.
141. Pike KE, Savage G, Villemagne VL, et al. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 2007, 130:2837-2844.
142. Sperling RA, Laviolette PS, O'Keefe K, et al. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 2009, 63:178-188.
143. Drzezga A, Becker JA, Van Dijk KR, et al. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134:1635-1646.
144. Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol 2010, 68:521-534.
145. Cotelli M, Calabria M, Manenti R, et al. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry 2011, 82:794-797.