Use of magnetoencephalography (MEG) to study functional brain networks in neurodegenerative disorders

Journal of the Neurological Sciences

Volumn 289, Issue 1-2, 2010, Pages 128-134

  Stam, C J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; Functional connectivity; Graph analysis; Magnetoencephalography; Oscillations; Parkinson's disease; Resting state; Small world networks; Synchronization

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA;

ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CINGULATE GYRUS; ELECTROENCEPHALOGRAM; HUMAN; MAGNETIC FIELD; MAGNETIC STIMULATION; MAGNETOENCEPHALOGRAPHY; MOTOR CORTEX; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OSCILLATION; PARKINSON DISEASE; PRIORITY JOURNAL;

ALZHEIMER DISEASE; BRAIN; ELECTROENCEPHALOGRAPHY; HUMANS; MAGNETOENCEPHALOGRAPHY; NERVE NET; NEURODEGENERATIVE DISEASES; NEUROPSYCHOLOGICAL TESTS; NONLINEAR DYNAMICS; PARKINSON DISEASE; SPECTRUM ANALYSIS;

EID: 74149085654     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.08.028     Document Type: Article

References (67)

1. Varela F., Lachaux J.P., Rodriguez E., and Martinerie J. The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2 (2001) 229-239
2. Uhlhaas P.J., and Singer W. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52 (2006) 155-168
3. Buzsaki G., and Draguhn A. Neuronal oscillation in cortical networks. Science 304 (2004) 1926-1929
4. Fries P. A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. TRENDS Cogn Neurosci 9 (2005) 474-480
5. Posthuma D., de Geus E.J.C., Mulder E.J.C.M., Smit D.J.A., Boomsma D.I., and Stam C.J. Genetic components of functional connectivity in the brain: the heritability of synchronization likelihood. Hum Brain Mapp 26 (2005) 191-198
6. Smit D.J.A., Stam C.J., Posthuma D., Boomsma D.I., and de Geus E. Heritability of 'small-world' networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity. Hum Brain Mapp 29 (2008) 1368-1378
7. Schnitzler A., and Gross J. Normal and pathological oscillatory communication in the brain. Nat Rev Neurosci 6 (2005) 285-296
8. Schnitzler A., and Gross J. Functional connectivity analysis in magnetoencephalography. Int Rev Neurobiol 68 (2005) 173-195
9. Pekkonen E., Ahveninen J., Virtanen J., and Teräväinen H. Parkinson's disease selectively impairs preattentive auditory processing: an MEG study. Neuroreport 9 (1998) 2949-2952
10. Anninos P.A., Adamopoulos A.V., Kotini A., and Tsagas N. Nonlinear analysis of brain activity in magnetic influenced Parkinson patients. Brain Topogr 13 (2000) 135-144
11. Kotini A., Anninos P., Adamopoulos A., and Prassopoulos P. Low-frequency MEG activity and MRI evaluation in Parkinson's disease. Brain Topogr. 18 (2005) 59-63
12. Anninos P., Adamopoulos A., Kotini A., Tsagas N., Tamiolakis D., and Prassopoulos P. MEG evaluation of Parkinson's diseased patients after external magnetic stimulation. Acta Neurol Belg. 107 (2007) 5-10
13. Timmermann L., Gross J., Dirks M., Volkmann J., Freund H.J., and Schnitzler A. The cerebral oscillatory network of parkinsonian resting tremor. Brain 126 (2003) 199-212
14. Stoffers D., Bosboom J.L.W., Wolters E.Ch., Berendse H.W., and Stam C.J. Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia. Brain 130 (2007) 1847-1860
15. Bosboom J.L.W., Stoffers D., Stam C.J., van Dijk B.W., Verbunt J., Berendse H.W., et al. Clin Neurophysiol 117 (2006) 2521-2531
16. Bosboom et al., submitted.
17. Osipova D., Ahveninen J., Kaakkola S., Jaaskelainen I.P., Huttunen J., and Pekkonen E. Effects of scopolamine on MEG spectral power and coherence in elderly subjects. Clin Neurophysiol 114 (2003) 1902-1907
18. Silberstein P., Pogosyan A., Kuhn A.A., Hotton G., Tisch S., Kupsch A., et al. Cortico-cortical coupling in Parkinson's disease and its modulation by therapy. Brain 128 (2005) 1277-1291
19. Stoffers D., Bosboom J.L.W., Deijen J.B., Wolters E.Ch., Stam C.J., and Berendse H.W. Increased cortico-cortical functional connectivity in early-stage Parkinson's disease: an MEG study. Neuroimage 41 2 (2008) 212-222
20. Stoffers D., Bosboom J.L.W., Wolters E.Ch., Stam C.J., and Berendse H.W. Dopaminergic modulation of cortico-cortical functional connectivity. Exp Neurol 213 1 (2008) 191-195
21. Bosboom JLW, Stoffers D, Wolters ECh, Stam CJ, Berendse HW. MEG resting state functional connectivity in Parkinson's disease related dementia. J Neural Transm [under revision].
22. Stam C.J., Jones B.F., Manshanden I., van Cappellen van Walsum A.M., Montez T., Verbunt J.P.A., et al. Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer's disease. Neuroimage 32 (2006) 1335-1344
23. Berendse H.W., and Stam C.J. Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease. Parkinsonism Relat Disord 13 (2007) S440-S445
24. Osipova D., Rantanen K., Ahveninen J., Ylikoski R., Happola O., Strandberg T., et al. Source estimation of spontaneous MEG oscillations in mild cognitive impairment. Neurosci Lett 405 (2006) 57-61
25. Maestu F., Campo P., Gil-Gregorio P., Fernandez S., Fernandez A., and Ortiz T. Medial temporal lobe neuromagnetic hypoactivation and risk for developing cognitive decline in elderly population: a 2-year follow up study. Neurobiol Aging 27 (2006) 32-37
26. Fernandez A., Hornero R., Mayo A., Poza J., Gil-Gregorio, and Ortiz T. MEG spectral profile in Alzheimer's disease and mild cognitive impairment. Clin Neurophysiol 117 (2006) 306-314
27. Fernandez A., Turrero A., Zuluaga P., Gil P., Maestu F., Campo P., et al. Magnetoencephalographic parietal delta dipole density in mild cognitive impairment. Preliminary results of a method to estimate the risk of developing Alzheimer disease. Arch Neurol 63 (2006) 427-430
28. Kurimoto R., Ishii R., Canuet L., Ikezawa K., Azechi M., Iwase M., et al. Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: an MEG study combining beamformer and group comparison. Neurosci Lett 443 (2008) 86-89
29. Berendse H.W., Verbunt J.P.A., Scheltens P., van Dijk B.W., and Jonkman E.J. Magnetoencephalographic analysis of cortical activity in Alzheimer's disease. A pilot study. Clin Neurophysiol 111 (2000) 604-612
30. Jeong J. EEG dynamics in patients with Alzheimer's disease. Clin Neurophysiol 115 (2004) 1490-1505
31. Fernandez A., Hornero R., Mayo A., Poza J., Maestu F., and Ortiz Alonso T. Quantitative magnetoencephalography of spontaneous brain activity in Alzheimer's disease. Alzheimer Dis Assoc Disord 20 (2006) 153-159
32. De Haan W., Stam C.J., Jones B.F., Zuiderwijk I.M., van Dijk B.W., and Scheltens P. Resting-state oscillatory brain dynamics in Alzheimer Disease. J Clin Neurophysiol 25 (2008) 187-193
33. Poza J., Hornero R., Abasolo D., Fernandez A., and Garcia M. Extraction of spectral based measures from MEG background oscillations in Alzheimer's disease. Med Eng Phys 29 (2007) 1073-1083
34. Poza J., Hornero R., Abásolo D., Fernández A., and Mayo A. Evaluation of spectral ratio measures from spontaneous MEG recordings in patients with Alzheimer's disease. Comput Methods Programs Biomed. 90 (2008) 137-147
35. Hornero R., Escudero J., Fernandez A., Poza J., and Gomez C. Spectral and nonlinear analyses of MEG background activity in patients with Alzheimer's disease. IEEE Trans Biomed Eng 55 (2008) 1658-1665
36. De Munck J.C., de Jongh A., and van Dijk B.W. The localization of spontaneous brain activity: an efficient way to analyze large data sets. IEEE Trans Biomed Eng 48 (2001) 1221-1228
37. Fernandez A., Maestu F., Amo C., Gil P., Fehr T., Wienbruch C., et al. Focal temporoparietal slow activity in Alzheimer's disease revealed by magnetoencephalography. Biol Psychiatry 52 (2002) 764-770
38. Fernandez A., Arazzola J., Maestu F., Amo C., Gil-Gregorio P., Wienbruch C., et al. Correlations of hippocampal atrophy and focal low-frequency magnetic activity in Alzheimer disease: volumetric MR imaging - magnetoencephalographic study. Am J Neuroradiol 24 (2003) 481-487
39. Fernandez A., Garcia-Seguria J.M., Ortiz T., Montoya J., Maestu F., Gil-Gregorio P., et al. Proton magnetic resonance spectroscopy and magnetoencephalographic estimation of delta dipole density: a combination of techniques that may contribute to the diagnosis of Alzheimer's disease. Dement Geriatr Cogn Disord 20 (2005) 169-177
40. Maestu F., Garcia-Segura J., Ortiz T., Montoya J., Fernandez A., Gil-Gregorio P., et al. Evidence of biochemical and biomagnetic interactions in Alzheimer's disease: an MEG and MR spectroscopic study. Dement Geriatr Cogn Disord 20 (2005) 145-152
41. Osipova D., Ahveninen J., Jensen O., Ylikoski A., and Pekkonen E. Altered generation of spontaneous oscillations in Alzheimer's disease. Neuroimage 27 (2005) 835-841
42. Escudero J., Hornero R., Poza J., Abásolo D., and Fernández A. Assessment of classification improvement in patients with Alzheimer's disease based on magnetoencephalogram blind source separation. Artif Intell Med. 43 (2008) 75-85
43. Damoiseaux J.S., Rombouts S.A.R.B., Barkhof F., Scheltens P., Stam C., Smith S.M., et al. Consistent resting-state networks across healthy subjects. PNAS 103 (2006) 13848-13853
44. Maestu F., Fernandez A., Simos P.G., Gil-Gregorio P., Amo C., Rodriguez R., et al. Spatio-temporal patterns of brain magnetic activity during a memory task in Alzheimer's disease. Neuroreport 12 (2001) 3917-3922
45. Maestu F., Arrazola J., Fernandez A., Simos P.G., Amo C., Gil-Gregorio P., et al. Do cognitive patterns of brain magnetic activity correlate with hippocampal atrophy in Alzheimer's disease?. J Neurol Neurosurg Psychiatry 74 (2003) 208-212
46. Maestu F., Fernandez A., Simos P.G., Lopez-Ibor M.I., Campo P., Criado J., et al. Profiles of brain magnetic activity during a memory task in patients with Alzheimer's disease and in non-demented elderly subjects, with or without depression. J Neurol Neurosurg Psychiatry 75 (2004) 1160-1162
47. Osipova D., Pekkonen E., and Ahveninen J. Enhanced auditory steady-state response in early Alzheimer's disease. Clin Neurophysiol 117 (2006) 1990-1995
48. Stam C.J. Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. Clin Neurophysiol 116 (2005) 2266-2301
49. Stam C.J., Breakspear M., van Cappellen van Walsum A.M., and van Dijk B.W. Nonlinear synchronization in EEG and whole-head MEG recordings of healthy subjects. Hum Brain Mapp 19 (2003) 63-78
50. Poza J., Hornero R., Abásolo D., Fernández A., and Escudero J. Analysis of spontaneous MEG activity in patients with Alzheimer's disease using spectral entropies. Conf Proc IEEE Eng Med Biol Soc. 2007 (2007) 6180-6183
51. Poza J., Hornero R., Escudero J., Fernandez A., and Sanchez C.I. Regional analysis of spontaneous MEG rhythms in patients with Alzheimer's disease using spectral entropies. Ann Biom Eng 36 (2008) 141-152
52. Gómez C., Hornero R., Abásolo D., Fernández A., and Escudero J. Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. Conf Proc IEEE Eng Med Biol Soc 2007 (2007) 6184-6187
53. Gomez C., Hornero R., Abasolo D., Fernandez A., and Escudero J. Analysis of the magnetoencephalogram background activity in Alzheimer's disease patients with auto-mutual information. Comput Methods Programs Biomed 87 (2007) 239-247
54. Gomez C., Hornero R., Abasolo D., Lopez M., and Fernandez A. Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms. Conf Proc IEEE Eng Med Biol Soc. 5 (2005) 4514-4517
55. Gomez C., Mediavilla A., Hornero R., Abasolo D., and Fernandez A. Use of Higuchi's fractal dimension for the analysis of MEG recordings from Alzheimer's disease patients. Med Eng Phys 31 3 (2009) 306-313
56. Abatzoglou I., Anninos P., Adamopoulos A., and Koukourakis M. Nonlinear analysis of brain magnetoencephalographic activity in Alzheimer disease patients. Acta Neurol Belg 107 (2007) 34-39
57. Tononi G., Sporns O., and Edelman G.M. A measure for brain complexity: relating functional segregation and integration in the nervous system. Proc Natl Acad Sci USA 91 (1994) 5033-5037
58. Stam C.J., and van Dijk B.W. Synchronization likelihood: an unbiased measure of generalized synchronization in multivariate data sets. Physica D 163 (2002) 236-241
59. Stam C.J., Nolte G., and Daffertshofer A. Phase lag index: assessment of functional connectivity from multichannel EEG and MEG with diminished bias from common sources. Hum Brain Mapp 28 (2007) 1178-1193
60. Stam C.J., van Cappellen van Walsum A.M., Pijnenburg Y.A.L., Berendse H.W., de Munck J.C., Scheltens P., et al. Generalized synchronization of MEG recordings in Alzheimer's disease: evidence for involvement of the gamma band. J Clin Neurophysiol 19 (2002) 562-574
61. van Cappellen van Walsum A.M., Pijnenburg Y.A.L., Berendse H.W., van Dijk B.W., Knol D.L., Scheltens P., et al. A neural complexity measure applied to MEG data in Alzheimer's disease. Clin Neurophysiol 114 (2003) 1034-1040
62. Stam CJ, de Haan W, Daffertshofer A, Jones BF, Manshanden I, van AM, et al. Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. Brain (accepted).
63. Stam C.J., and Reijneveld J.C. Graph theoretical analysis of complex networks in the brain. Nonlinear Biomed Phys 1 (2007) 3 10.1186/1753-4631-1-3 [2761]
64. Jonkman E.J. The role of the electroencephalogram in the diagnosis of dementia of the Alzheimer type: an attempt at technology assessment. Neurophysiol Clin 27 (1997) 211-219
65. Georgopoulos A.P., Karageorgiou E., Leuthold A.C., Lewis S.M., Lynch J.K., Alonso A.A., et al. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng 4 (2007) 349-355
66. Zotev V.S., Matlashov A.N., Volegov P.L., Savukov I.M., Espy M.A., Mosher J.C., et al. Microtesla MRI of the human brain combined with MEG. J Magn Reson 194 (2008) 115-120
67. Reijneveld J.C., Ponten S.C., Berendse H.W., and Stam C.J. The application of graph theoretical analysis to complex networks in the brain. Clin Neurophysiol 118 (2007) 2317-2331