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Volumn 23, Issue 9, 2011, Pages 778-790

Triiodothyronine Administration Ameliorates the Demyelination/Remyelination Ratio in a Non-Human Primate Model of Multiple Sclerosis by Correcting Tissue Hypothyroidism

Author keywords

Experimental allergic encephalomyelitis; Marmoset; Oligodendrocyte precursor cells; Remyelination; Thyroid hormone

Indexed keywords

LIOTHYRONINE; MESSENGER RNA; THYROID HORMONE RECEPTOR;

EID: 80051571769     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2011.02181.x     Document Type: Article
Times cited : (35)

References (59)
  • 1
    • 78650172976 scopus 로고    scopus 로고
    • Inflammation, demyelination, and degeneration - recent insights from MS pathology
    • Stadelmann C, Wegner C, Bruck W. Inflammation, demyelination, and degeneration - recent insights from MS pathology. Biochim Biophys Acta 2011; 1812: 275-282.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 275-282
    • Stadelmann, C.1    Wegner, C.2    Bruck, W.3
  • 2
    • 51849102869 scopus 로고    scopus 로고
    • The life, death, and replacement of oligodendrocytes in the adult CNS
    • McTigue DM, Tripathi RB. The life, death, and replacement of oligodendrocytes in the adult CNS. J Neurochem 2008; 107: 1-19.
    • (2008) J Neurochem , vol.107 , pp. 1-19
    • McTigue, D.M.1    Tripathi, R.B.2
  • 4
    • 33746055320 scopus 로고    scopus 로고
    • Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions
    • Wilson HC, Scolding NJ, Raine CS. Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol 2006; 176: 162-173.
    • (2006) J Neuroimmunol , vol.176 , pp. 162-173
    • Wilson, H.C.1    Scolding, N.J.2    Raine, C.S.3
  • 5
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008; 131: 1749-1758.
    • (2008) Brain , vol.131 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Bruck, W.6
  • 6
    • 20444463024 scopus 로고    scopus 로고
    • Promoting repair in multiple sclerosis: problems and prospects
    • Lubetzki C, Williams A, Stankoff B. Promoting repair in multiple sclerosis: problems and prospects. Curr Opin Neurol 2005; 18: 237-2344.
    • (2005) Curr Opin Neurol , vol.18 , pp. 237-2344
    • Lubetzki, C.1    Williams, A.2    Stankoff, B.3
  • 7
    • 35548986727 scopus 로고    scopus 로고
    • Dissecting demyelination
    • Miller RH, Mi S. Dissecting demyelination. Nat Neurosci 2007; 10: 1351-1354.
    • (2007) Nat Neurosci , vol.10 , pp. 1351-1354
    • Miller, R.H.1    Mi, S.2
  • 8
    • 0036213045 scopus 로고    scopus 로고
    • Action of thyroid hormone in brain
    • Bernal J. Action of thyroid hormone in brain. J Endocrinol Invest 2002; 25: 268-288.
    • (2002) J Endocrinol Invest , vol.25 , pp. 268-288
    • Bernal, J.1
  • 9
    • 8544225040 scopus 로고    scopus 로고
    • Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings
    • Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol 2004; 16: 809-818.
    • (2004) J Neuroendocrinol , vol.16 , pp. 809-818
    • Zoeller, R.T.1    Rovet, J.2
  • 10
    • 71849115046 scopus 로고    scopus 로고
    • Thyroid hormone action during development: more questions than answer
    • Horn S, Heuer H. Thyroid hormone action during development: more questions than answer. Mol Cell Endocrinol 2010; 315: 19-26.
    • (2010) Mol Cell Endocrinol , vol.315 , pp. 19-26
    • Horn, S.1    Heuer, H.2
  • 11
    • 0036936394 scopus 로고    scopus 로고
    • Insight into the physiological actions of thyroid hormone receptors from genetically modified mice
    • O'Shea PJ, Williams GR. Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. J Endocrinol 2002; 175: 553-570.
    • (2002) J Endocrinol , vol.175 , pp. 553-570
    • O'Shea, P.J.1    Williams, G.R.2
  • 12
    • 79851515913 scopus 로고    scopus 로고
    • Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development
    • Babu S, Sinha RA, Mohan V, Rao G, Pal A, Pathak A, Singh M, Godbole MM. Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Exp Neurol 2011; 228: 91-98.
    • (2011) Exp Neurol , vol.228 , pp. 91-98
    • Babu, S.1    Sinha, R.A.2    Mohan, V.3    Rao, G.4    Pal, A.5    Pathak, A.6    Singh, M.7    Godbole, M.M.8
  • 13
    • 0031128313 scopus 로고    scopus 로고
    • Oligodendrocyte maturation and progenitor cell proliferation are independently regulated by thyroid hormone
    • Baas D, Bourbeau D, Sarliève LL, Ittel ME, Dussault JH, Puymirat J. Oligodendrocyte maturation and progenitor cell proliferation are independently regulated by thyroid hormone. Glia 1997; 19: 324-332.
    • (1997) Glia , vol.19 , pp. 324-332
    • Baas, D.1    Bourbeau, D.2    Sarliève, L.L.3    Ittel, M.E.4    Dussault, J.H.5    Puymirat, J.6
  • 14
    • 4944242377 scopus 로고    scopus 로고
    • Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat
    • Fernández M, Pirondi S, Manservigi M, Giardino L, Calzà L. Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Eur J Neurosci 2004; 20: 2059-2070.
    • (2004) Eur J Neurosci , vol.20 , pp. 2059-2070
    • Fernández, M.1    Pirondi, S.2    Manservigi, M.3    Giardino, L.4    Calzà, L.5
  • 15
    • 70449533660 scopus 로고    scopus 로고
    • Thyroid hormone induces glial lineage of primary neurospheres derived from non-pathological and pathological rat brain: implications for remyelination-enhancing therapies
    • Fernández M, Paradisi M, Del Vecchio G, Giardino L, Calzà L. Thyroid hormone induces glial lineage of primary neurospheres derived from non-pathological and pathological rat brain: implications for remyelination-enhancing therapies. Int J Dev Neurosci 2009; 27: 769-778.
    • (2009) Int J Dev Neurosci , vol.27 , pp. 769-778
    • Fernández, M.1    Paradisi, M.2    Del Vecchio, G.3    Giardino, L.4    Calzà, L.5
  • 16
    • 0037022609 scopus 로고    scopus 로고
    • Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis
    • Calzà L, Fernandez M, Giuliani A, Aloe L, Giardino L. Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc Natl Acad Sci USA 2002; 99: 3258-3263.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3258-3263
    • Calzà, L.1    Fernandez, M.2    Giuliani, A.3    Aloe, L.4    Giardino, L.5
  • 19
    • 74749090493 scopus 로고    scopus 로고
    • Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells
    • Calzà L, Fernandez M, Giardino L. Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. J Mol Endocrinol 2010; 44: 13-23.
    • (2010) J Mol Endocrinol , vol.44 , pp. 13-23
    • Calzà, L.1    Fernandez, M.2    Giardino, L.3
  • 21
    • 47549088244 scopus 로고    scopus 로고
    • Thyroid hormones promote differentiation of remyelination after cuprizone-induced demyelination
    • Franco PG, Silvestroff L, Soto EF, Pasquini JM. Thyroid hormones promote differentiation of remyelination after cuprizone-induced demyelination. Exp Neurol 2008; 212: 458-467.
    • (2008) Exp Neurol , vol.212 , pp. 458-467
    • Franco, P.G.1    Silvestroff, L.2    Soto, E.F.3    Pasquini, J.M.4
  • 23
    • 0034657843 scopus 로고    scopus 로고
    • Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system
    • Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med 2000; 191: 1799-1806.
    • (2000) J Exp Med , vol.191 , pp. 1799-1806
    • Villoslada, P.1    Hauser, S.L.2    Bartke, I.3    Unger, J.4    Heald, N.5    Rosenberg, D.6    Cheung, S.W.7    Mobley, W.C.8    Fisher, S.9    Genain, C.P.10
  • 24
    • 27644535269 scopus 로고    scopus 로고
    • Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis
    • Pomeroy IM, Matthews PM, Frank JA, Jordan EK, Esiri MM. Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis. Brain 2005; 128: 2713-2721.
    • (2005) Brain , vol.128 , pp. 2713-2721
    • Pomeroy, I.M.1    Matthews, P.M.2    Frank, J.A.3    Jordan, E.K.4    Esiri, M.M.5
  • 25
    • 77954564262 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development
    • Kap YS, Laman JD, 't Hart BA. Experimental autoimmune encephalomyelitis in common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development. J Neuroimmune Pharmacol 2010; 5: 220-230.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 220-230
    • Kap, Y.S.1    Laman, J.D.2    't Hart, B.A.3
  • 27
    • 39549095428 scopus 로고    scopus 로고
    • A hormone map of human immune cells showing the presence of adrenocorticotropic hormone, triiodothyronine and endorphin in immunophenotyped white blood cells
    • Pallinger E, Csaba G. A hormone map of human immune cells showing the presence of adrenocorticotropic hormone, triiodothyronine and endorphin in immunophenotyped white blood cells. Immunology 2008; 123: 584-589.
    • (2008) Immunology , vol.123 , pp. 584-589
    • Pallinger, E.1    Csaba, G.2
  • 28
    • 33646345584 scopus 로고    scopus 로고
    • Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway
    • Klecha AJ, Klecha AJ, Genaro AM, Gorelik G, Barreiro Arcos ML, Silberman DM, Schuman M, Garcia SI, Pirola C, Cremaschi GA. Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. J Endocrinol 2006; 189: 45-55.
    • (2006) J Endocrinol , vol.189 , pp. 45-55
    • Klecha, A.J.1    Klecha, A.J.2    Genaro, A.M.3    Gorelik, G.4    Barreiro Arcos, M.L.5    Silberman, D.M.6    Schuman, M.7    Garcia, S.I.8    Pirola, C.9    Cremaschi, G.A.10
  • 30
    • 0037073588 scopus 로고    scopus 로고
    • Thyroid hormones stimulate expression and modification of cytoskeletal protein during rat sciatic nerve regeneration
    • Shenker M, Riederer BM, Kuntzer T, Barakat-Walter I. Thyroid hormones stimulate expression and modification of cytoskeletal protein during rat sciatic nerve regeneration. Brain Res 2002; 957: 259-270.
    • (2002) Brain Res , vol.957 , pp. 259-270
    • Shenker, M.1    Riederer, B.M.2    Kuntzer, T.3    Barakat-Walter, I.4
  • 31
    • 33646764917 scopus 로고    scopus 로고
    • Thyroid hormone and astrocyte morphogenesis
    • Trentin AG. Thyroid hormone and astrocyte morphogenesis. J Endocrinol 2006; 189: 189-197.
    • (2006) J Endocrinol , vol.189 , pp. 189-197
    • Trentin, A.G.1
  • 33
    • 0032539826 scopus 로고    scopus 로고
    • Proliferation and phenotype regulation in the subventricular zone during experimental encephalomyelitis in vivo evidence of a role for nerve growth factor
    • Calzà L, Giardino L, Pozza M, Bettelli C, Micera A, Aloe L. Proliferation and phenotype regulation in the subventricular zone during experimental encephalomyelitis in vivo evidence of a role for nerve growth factor. Proc Natl Acad Sci USA 1998; 95: 3209-3214.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3209-3214
    • Calzà, L.1    Giardino, L.2    Pozza, M.3    Bettelli, C.4    Micera, A.5    Aloe, L.6
  • 35
    • 27744455099 scopus 로고    scopus 로고
    • Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS
    • Jakovcevski I, Zecevic N. Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. J Neurosci 2005; 25: 10064-10073.
    • (2005) J Neurosci , vol.25 , pp. 10064-10073
    • Jakovcevski, I.1    Zecevic, N.2
  • 36
    • 78149329463 scopus 로고    scopus 로고
    • Regulation of oligodendrocyte differentiation and myelination
    • Emery B. Regulation of oligodendrocyte differentiation and myelination. Science 2010; 330: 779-782.
    • (2010) Science , vol.330 , pp. 779-782
    • Emery, B.1
  • 38
    • 0034611002 scopus 로고    scopus 로고
    • Long-term culture of purified postnatal oligodendrocyte precursor cells. Evidence for an intrinsic maturation program that plays out over months
    • Tang DG, Tokumoto YM, Raff MC. Long-term culture of purified postnatal oligodendrocyte precursor cells. Evidence for an intrinsic maturation program that plays out over months. J Cell Biol 2000; 148: 971-984.
    • (2000) J Cell Biol , vol.148 , pp. 971-984
    • Tang, D.G.1    Tokumoto, Y.M.2    Raff, M.C.3
  • 39
    • 0033957316 scopus 로고    scopus 로고
    • A cell-intrinsic timer that operates during oligodendrocyte development
    • Durand B, Raff M. A cell-intrinsic timer that operates during oligodendrocyte development. BioAssays 2000; 22: 64-71.
    • (2000) BioAssays , vol.22 , pp. 64-71
    • Durand, B.1    Raff, M.2
  • 40
    • 0037022565 scopus 로고    scopus 로고
    • Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors
    • Baas D, Legrand C, Samarut J, Flamant F. Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors. Proc Natl Acad Sci USA 2002; 99: 2907-2911.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2907-2911
    • Baas, D.1    Legrand, C.2    Samarut, J.3    Flamant, F.4
  • 41
    • 84887212627 scopus 로고    scopus 로고
    • Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-Chip in developing mouse cerebellum
    • Dong H, Yauk CL, Rowan-Carroll A, You S-E, Zoeller T, Lambert I, Wade MG. Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-Chip in developing mouse cerebellum. PLoS ONE 2009; 4: e4610.
    • (2009) PLoS ONE , vol.4
    • Dong, H.1    Yauk, C.L.2    Rowan-Carroll, A.3    You, S.-E.4    Zoeller, T.5    Lambert, I.6    Wade, M.G.7
  • 42
    • 0036191639 scopus 로고    scopus 로고
    • Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
    • Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 2002; 23: 38-89.
    • (2002) Endocr Rev , vol.23 , pp. 38-89
    • Bianco, A.C.1    Salvatore, D.2    Gereben, B.3    Berry, M.J.4    Larsen, P.R.5
  • 43
    • 77953639982 scopus 로고    scopus 로고
    • Molecular aspects of thyroid hormone actions
    • Cheng S-Y, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev 2010; 31: 139-170.
    • (2010) Endocr Rev , vol.31 , pp. 139-170
    • Cheng, S.-Y.1    Leonard, J.L.2    Davis, P.J.3
  • 44
    • 53549096766 scopus 로고    scopus 로고
    • Modeling the nonthyroidal illness syndrome
    • Koenig RJ. Modeling the nonthyroidal illness syndrome. Curr Opin Endocrinol Diabetes Obes 2008; 15: 466-469.
    • (2008) Curr Opin Endocrinol Diabetes Obes , vol.15 , pp. 466-469
    • Koenig, R.J.1
  • 45
    • 77949511133 scopus 로고    scopus 로고
    • Mechanisms behind the non-thyroidal illness syndrome: an update
    • Warner MH, Beckett GJ. Mechanisms behind the non-thyroidal illness syndrome: an update. J Endocrinol 2010; 205: 1-13.
    • (2010) J Endocrinol , vol.205 , pp. 1-13
    • Warner, M.H.1    Beckett, G.J.2
  • 46
    • 33846805764 scopus 로고    scopus 로고
    • Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake
    • Boelen A, Kwakkel J, Wiersinga WM, Fliers E. Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J Endocrinol 2006; 191: 707-714.
    • (2006) J Endocrinol , vol.191 , pp. 707-714
    • Boelen, A.1    Kwakkel, J.2    Wiersinga, W.M.3    Fliers, E.4
  • 48
    • 0034522236 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II
    • Baur A, Bauer K, Jarry H, Köhrle J. Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II. J Endocrinol 2000; 167: 505-515.
    • (2000) J Endocrinol , vol.167 , pp. 505-515
    • Baur, A.1    Bauer, K.2    Jarry, H.3    Köhrle, J.4
  • 49
    • 33646342231 scopus 로고    scopus 로고
    • Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA
    • Kwakkel J, Wiersinga WM, Boelen A. Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA. J Endocrinol 2006; 189: 37-44.
    • (2006) J Endocrinol , vol.189 , pp. 37-44
    • Kwakkel, J.1    Wiersinga, W.M.2    Boelen, A.3
  • 52
    • 75449089854 scopus 로고    scopus 로고
    • Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis
    • Boelen A, Mikita J, Boiziau C, Chassande O, Fliers E, Petry KG. Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis. Thyroid 2009; 19: 1401-1406.
    • (2009) Thyroid , vol.19 , pp. 1401-1406
    • Boelen, A.1    Mikita, J.2    Boiziau, C.3    Chassande, O.4    Fliers, E.5    Petry, K.G.6
  • 53
    • 7244227780 scopus 로고    scopus 로고
    • Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis
    • Boelen A, Kwakkel J, Platvoet-ter Schphorst M, Boelen A. Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. Eur J Endocrinol 2004; 151: 497-502.
    • (2004) Eur J Endocrinol , vol.151 , pp. 497-502
    • Boelen, A.1    Kwakkel, J.2    Platvoet-ter Schphorst, M.3    Boelen, A.4
  • 54
    • 34547860383 scopus 로고    scopus 로고
    • Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells
    • Kwakkel J, Wiersinga WM, Boelen A. Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells. J Endocrinol 2007; 194: 257-265.
    • (2007) J Endocrinol , vol.194 , pp. 257-265
    • Kwakkel, J.1    Wiersinga, W.M.2    Boelen, A.3
  • 55
    • 77957827876 scopus 로고    scopus 로고
    • Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock
    • Lado-Abeal J, Romero A, Castro-Piedras I, Rodriguez-Perez A, Alvarez-Escudero J. Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock. Eur J Endocrinol 2010; 163: 765-773.
    • (2010) Eur J Endocrinol , vol.163 , pp. 765-773
    • Lado-Abeal, J.1    Romero, A.2    Castro-Piedras, I.3    Rodriguez-Perez, A.4    Alvarez-Escudero, J.5
  • 57
    • 0034803348 scopus 로고    scopus 로고
    • Blood levels of selected hormones in patients with multiple sclerosis
    • Zych-Twardowska E, Wajgt A. Blood levels of selected hormones in patients with multiple sclerosis. Med Sci Monit 2001; 7: 1005-1012.
    • (2001) Med Sci Monit , vol.7 , pp. 1005-1012
    • Zych-Twardowska, E.1    Wajgt, A.2
  • 58
    • 65349103656 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica
    • Jiang Y, Yang Y, Zhang B, Peng F, Bao J, Hu X. Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica. Neuroendocrinol Lett 2009; 30: 85-90.
    • (2009) Neuroendocrinol Lett , vol.30 , pp. 85-90
    • Jiang, Y.1    Yang, Y.2    Zhang, B.3    Peng, F.4    Bao, J.5    Hu, X.6


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