Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system

Journal of Experimental Medicine

Volumn 191, Issue 10, 2000, Pages 1799-1806

  Villoslada, Pablo ^a,b   Hauser, Stephen L ^a   Bartke, Ilse ^c   Unger, Jurgen ^d   Heald, Nathan ^a   Rosenberg, Daniel ^a   Cheung, Steven W ^a   Mobley, William C ^a   Fisher, Stefan ^c   Genain, Claude P ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Growth factors; Interferon ; Interleukin 10; Multiple sclerosis; Nonhuman primate

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GROWTH FACTOR; INTERLEUKIN 10; RECOMBINANT NERVE GROWTH FACTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; DEMYELINATION; HELPER CELL; IMMUNOCYTOCHEMISTRY; INTERFERON PRODUCTION; MARMOSET; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SCORING SYSTEM;

ANIMALS; CALLITHRIX; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; NERVE GROWTH FACTOR; RECOMBINANT PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 0034657843     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.10.1799     Document Type: Article

References (30)

1. Raine, C. 1997. Demyelinating diseases. In Textbook of Neuropathology. 3rd ed. R. Davis and D. Robertson, editors. Williams & Wilkins, Baltimore. 627-714.
2. Hohlfeld, R. 1997. Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives. Brain. 120:865-916.
3. Althaus, H., S. Kloppner, T. Schmidt-Schultz, and P. Schwartz. 1992. Nerve growth factor induces proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain. Neurosci. Lett. 135:219-223.
4. Cohen, R., R. Marmur, W. Norton, M. Mehler, and J. Kessler. 1996. Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J. Neurosci. 16:6433-6442.
5. Urschel, B., and C. Hulsebosch. 1990. Schwann cell-neuronal interactions in the rat involve nerve growth factor. J. Comp. Neurol. 296:114-122.
6. Bothwell, M. 1995. Functional interactions of neurotrophins and neurotrophin receptors. Annu. Rev. Neurosci. 18:223-253.
7. Carter, B., and G. Lewin. 1997. Neurotrophins live or let die:does p75NTR decide? Neuron. 18:187-190.
8. Lewin, G., and Y. Barde. 1996. Physiology of the neurotrophins. Annu. Rev. Neurosci. 19:289-317.
9. Levi-Montalcini, R., S. Skaper, R. Dal Toso, L. Petrelli, and A. Leon. 1996. Nerve growth factor:from neurotropin to neurokine. Trends Neurosci. 19:514-520.
10. Stephan, H., G. Baron, and W. Schwerdtfeger. 1980. The brain of the common marmoset (Callithrix jacchus). A stereotaxic atlas. Springer-Verlag, Berlin/Heidelberg/New York. 93 pp.
11. Genain, C.P., M.H. Nguyen, N.L. Letvin, R. Pearl, R.L. Davis, M. Adelman, M.B. Lees, C. Linington, and S.L. Hauser. 1995. Antibody facilitation of multiple sclerosis-like lesions in a non human primate. J. Clin. Invest. 96:2966-2974.
12. Barde, Y., D. Edgar, and H. Thoenen. 1980. Sensory neurons in culture:changing requirements for survival factors during embryonic development. Proc. Natl. Acad. Sci. USA. 77:1199-1203.
13. Longo, F., D. Holtzman, M. Grimes, and W. Mobley. 1992. Nerve growth factor:actions in the peripheral and central nervous systems. In Neurotrophic Factors. J. Fallon and S. Loughlin, editors. Academic Press, New York. 209-256.
14. Genain, C., B. Cannella, S. Hauser, and C. Raine. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:170-175.
15. Webster, H.D. 1997. Growth factors and myelin regeneration in multiple sclerosis. Mult. Scler. 3:113-120.
16. Cannella, B., C. Hoban, Y. Gao, R. Garcia-Arenas, D. Lawson, M. Marchionni, D. Gwynne, and C. Raine. 1998. The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis. Proc. Natl. Acad. Sci. USA. 95:10100-10105.
17. Lovett-Racke, A., P. Bittner, A. Cross, J. Carlino, and M. Racke. 1998. Regulation of experimental allergic encephalomyelitis with insulin growth factor (IGF-1) and IGF-1/1GF-binding protein-3 complex (IGF/IGFBP3). J. Clin. Invest. 101:1797-1804.
18. Kramer, R., Y. Zhang, J. Gehrmann, R. Gold, H. Thoenen, and H. Wekerle. 1995. Gene transfer through the blood-nerve barrier:NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis. Nat. Med. 1:1162-1166.
19. Charlton, B., and K. Lafferty. 1995. The Th1/Th2 balance in autoimmunity. Curr. Opin. Immunol. 7:793-798.
20. Kossmann, T., V. Hans, H. Imhof, O. Trentz, and M. Morgantikossmann. 1996. Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Res. 713: 143-152.
21. De Simone, R., A. Micera, P. Tirassa, and L. Aloe. 1996. mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. Neuropathol. Appl. Neurobiol. 22:54-59.
22. Laudiero, L.B., L. Aloe, R. Levi-Montalcini, C. Buttinelli, D. Schilter, S. Gillessen, and U. Otten. 1992. Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid. Neurosci. Lett. 147:9-12.
23. Gadient, R.A., K.C. Cron, and U. Otten. 1990. Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes. Neurosci. Lett. 117:335-340.
24. Awatsuji, H., Y. Furukawa, M. Hirota, Y. Murakami, S. Nii, S. Furukawa, and K. Hayashi. 1993. Interleukin-4 and -5 as modulators of nerve growth factor synthesis/secretion in astrocytes. J. Neurosci. Res. 34:539-545.
25. Dugan, L.L., D.J. Creedon, E.M. Johnson, Jr., and D.M. Holtzman. 1997. Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA. 94:4086-4091.
26. Fierz, W., B. Endler, K. Reske, H. Wekerle, and A. Fontana. 1985. Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. J. Immunol. 134:3785-3793.
27. Williams, K., N. Dooley, E. Ulvestad, B. Becher, and J. Antel. 1996. IL-10 production by adult human derived microglial cells. Neurochem. Int. 29:55-64.
28. Neumann, H., T. Misgeld, K. Matsumuro, and H. Wekerle. 1998. Neurotrophins inhibit major histocompatibility class II inducibility of microglia:involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. USA. 95:5779-5784.
29. Trapp, B., J. Peterson, R. Ransohoff, R. Rudick, S. Mork, and L. Bo. 1998. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338:278-285.
30. Steinman, L. 2000. Multiple approaches to multiple sclerosis. Nat. Med. 6:15-16.