Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness

Critical Care

Volumn 13, Issue 5, 2009, Pages

  Mebis, Liese ^a   Debaveye, Yves ^a   Ellger, Björn ^a   Derde, Sarah ^a   Ververs, Eric Jan ^a   Langouche, Lies ^a   Darras, Veerle M ^a   Fliers, Eric ^b   Visser, Theo J ^c   Van den Berghe, Greet ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IODOTHYRONINE DIODINASE TYPE II; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 10; MONOCARBOXYLATE TRANSPORTER 8; ORGANIC ANION CO TRANSPORTING POLYPEPTIDE 1C1; ORGANIC ANION TRANSPORTER; OXIDOREDUCTASE; PROTIRELIN; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; THYROXINE; UNCLASSIFIED DRUG; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; IODOTHYRONINE DEIODINASE TYPE III; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; GENE EXPRESSION; GENE REPRESSION; HORMONE BLOOD LEVEL; HYPOPHYSIS THYROID SYSTEM; MALE; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; THYROTOXICOSIS; ANIMAL; COMPARATIVE STUDY; DNA SEQUENCE; EUTHYROID SICK SYNDROME; FLUORESCENCE; GENETICS; HYPOPHYSIS; HYPOTHALAMUS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SECRETION; THYROID GLAND;

ANIMALS; CRITICAL ILLNESS; EUTHYROID SICK SYNDROMES; FLUORESCENCE; HYPOTHALAMUS; IODIDE PEROXIDASE; MALE; MODELS, ANIMAL; ORGANIC ANION TRANSPORTERS; PITUITARY GLAND; POLYMERASE CHAIN REACTION; RABBITS; RNA; SEQUENCE ANALYSIS, DNA; SUPPRESSION, GENETIC; THYROID GLAND; THYROTOXICOSIS; THYROTROPIN-RELEASING HORMONE;

EID: 70549107639     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8043     Document Type: Article

References (32)

1. Berghe G, de Zegher F, Baxter RC, Veldhuis JD, Wouters P, Schetz M, Verwaest C, Vorst E, Lauwers P, Bouillon R, Bowers CY. Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. J Clin Endocrinol Metab 1998, 83:309-319. 10.1210/jc.83.2.309, 9467533.
2. Peeters RP, Wouters PJ, van Toor H, Kaptein E, Visser TJ, Berghe G. Serum 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities. J Clin Endocrinol Metab 2005, 90:4559-4565. 10.1210/jc.2005-0535, 15886232.
3. Berghe G, de Zegher F, Veldhuis JD, Wouters P, Gouwy S, Stockman W, Weekers F, Schetz M, Lauwers P, Bouillon R, Bowers CY. Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. Clin Endocrinol (Oxf) 1997, 47:599-612. 10.1046/j.1365-2265.1997.3371118.x, 9425400.
4. Fliers E, Guldenaar SE, Wiersinga WM, Swaab DF. Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab 1997, 82:4032-4036. 10.1210/jc.82.12.4032, 9398708.
5. Crantz FR, Silva JE, Larsen PR. An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 1982, 110:367-375. 10.1210/endo-110-2-367, 6276132.
6. Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM. Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J Endocrinol 2004, 182:315-323. 10.1677/joe.0.1820315, 15283692.
7. Diano S, Naftolin F, Goglia F, Horvath TL. Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 1998, 139:2879-2884. 10.1210/en.139.6.2879, 9607797.
8. Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology 2004, 145:1649-1655. 10.1210/en.2003-1439, 14684601.
9. Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res 2005, 1056:97-99. 10.1016/j.brainres.2005.07.021, 16095572.
10. Boelen A, Kwakkel J, Wiersinga WM, Fliers E. Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J Endocrinol 2006, 191:707-714. 10.1677/joe.1.07056, 17170227.
11. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 2002, 16:2283-2296. 10.1210/me.2001-0309, 12351693.
12. Tohyama K, Kusuhara H, Sugiyama Y. Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology 2004, 145:4384-4391. 10.1210/en.2004-0058, 15166123.
13. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, Sugiyama Y. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J Biol Chem 2003, 278:43489-43495. 10.1074/jbc.M306933200, 12923172.
14. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 2003, 278:40128-40135. 10.1074/jbc.M300909200, 12871948.
15. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S. Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 2006, 147:4036-4043. 10.1210/en.2006-0390, 16709608.
16. Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest 2007, 117:627-635. 1797602, 17318265, 10.1172/JCI28253.
17. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 2001, 276:17221-17228. 10.1074/jbc.M009462200, 11278508.
18. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics 2002, 79:95-103. 10.1006/geno.2001.6678, 11827462.
19. Friesema EC, Jansen J, Jachtenberg JW, Visser WE, Kester MH, Visser TJ. Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. Mol Endocrinol 2008, 22:1357-1369. 10.1210/me.2007-0112, 18337592.
20. Weekers F, Van Herck E, Coopmans W, Michalaki M, Bowers CY, Veldhuis JD, Berghe G. A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response. Endocrinology 2002, 143:764-774. 10.1210/en.143.3.764, 11861495.
21. Debaveye Y, Ellger B, Mebis L, Van Herck E, Coopmans W, Darras VM, Berghe G. Tissue deiodinase activity during prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone-releasing peptide-2. Endocrinology 2005, 146:5604-5611. 10.1210/en.2005-0963, 16150898.
22. Geyten S, Eynde I, Segers IB, Kuhn ER, Darras VM. Differential expression of iodothyronine deiodinases in chicken tissues during the last week of embryonic development. Gen Comp Endocrinol 2002, 128:65-73. 10.1016/S0016-6480(02)00065-5, 12270789.
23. Schatz DL, Sheppard RH, Steiner G, Chandarlapaty CS, de Veber GA. Influence of heparin on serum free thyroxine. J Clin Endocrinol Metab 1969, 29:1015-1022. 10.1210/jcem-29-8-1015, 4979449.
24. Salvatore D, Bartha T, Harney JW, Larsen PR. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 1996, 137:3308-3315. 10.1210/en.137.8.3308, 8754756.
25. Morreale de Escobar G, Pastor R, Obregon MJ, Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 1985, 117:1890-1900. 10.1210/endo-117-5-1890, 4042969.
26. Morreale de Escobar G, Calvo R, Escobar del Rey F, Obregon MJ. Thyroid hormones in tissues from fetal and adult rats. Endocrinology 1994, 134:2410-2415. 10.1210/en.134.6.2410, 8194467.
27. Fekete C, Lechan RM. Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol 2007, 28:97-114. 2000455, 17588648, 10.1016/j.yfrne.2007.04.002.
28. Alkemade A, Friesema EC, Unmehopa UA, Fabriek BO, Kuiper GG, Leonard JL, Wiersinga WM, Swaab DF, Visser TJ, Fliers E. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J Clin Endocrinol Metab 2005, 90:4322-4334. 10.1210/jc.2004-2567, 15840737.
29. Ramadan T, Camargo SM, Summa V, Hunziker P, Chesnov S, Pos KM, Verrey F. Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway. J Cell Physiol 2006, 206:771-779. 10.1002/jcp.20531, 16245314.
30. Clerget-Froidevaux MS, Seugnet I, Demeneix BA. Thyroid status co-regulates thyroid hormone receptor and co-modulator genes specifically in the hypothalamus. FEBS Lett 2004, 569:341-345. 10.1016/j.febslet.2004.05.076, 15225659.
31. Arem R, Wiener GJ, Kaplan SG, Kim HS, Reichlin S, Kaplan MM. Reduced tissue thyroid hormone levels in fatal illness. Metabolism 1993, 42:1102-1108. 10.1016/0026-0495(93)90266-Q, 8412761.
32. Mebis L, Langouche L, Visser TJ, Berghe G. The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness. J Clin Endocrinol Metab 2007, 92:3330-3333. 10.1210/jc.2007-0510, 17504898.