Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration

Neurobiology of Aging

Volumn 32, Issue 10, 2011, Pages 1827-1838

  Kulic, Luka ^a   Wollmer, M Axel ^a   Rhein, Virginie ^b   Pagani, Lucia ^b   Kuehnle, Katrin ^a   Cattepoel, Susann ^a   Tracy, Jay ^a   Eckert, Anne ^b   Nitsch, Roger M ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

AIF; Harlequin; Mitochondrial dysfunction; Neurodegeneration; Oxidative stress; Tau

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS INDUCING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DENTATE GYRUS; DISEASE EXACERBATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; GENE MUTATION; HARLEQUIN MOUSE; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MOTOR DYSFUNCTION; MOUSE; MOUSE STRAIN; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; P301L TAU MOUSE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RESPIRATORY CHAIN; TAU GENE; TAUOPATHY; TRANSGENE; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BRAIN; CASPASE 3; ELECTRON TRANSPORT COMPLEX I; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IN SITU NICK-END LABELING; LEUCINE; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MOVEMENT DISORDERS; MUTATION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROLINE; PROTON PUMPS; SILVER STAINING; STATISTICS, NONPARAMETRIC; TAU PROTEINS; TAUOPATHIES;

EID: 80051570051     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.10.014     Document Type: Article

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