Cholinergic ion secretion in human colon requires coactivation by cAMP

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 6 38-6, 1998, Pages

  Mall, M ^a,b   Bleich, M ^b   Schurlein M ^b   Kuhr J ^b   Seydewitz, H H ^b   Brandis, M ^b   Greger, R ^a   Kunzelmann, K ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Carbachol; Cystic fibrosis transmembrane conductance regulator; Epithelial transport; Microelectrodes; Potassium channels; Transepithelial voltage; Ussing chamber

Indexed keywords

CALCIUM; CARBACHOL; CHLORIDE ION; CYCLIC AMP; POTASSIUM CHANNEL; POTASSIUM ION;

ADOLESCENT; ADULT; AGED; ARTICLE; CALCIUM CELL LEVEL; CHILD; CHLORIDE TRANSPORT; CLINICAL ARTICLE; COLON MUCOSA; COLON SECRETION; ELECTRIC POTENTIAL; HUMAN; HUMAN TISSUE; MICROELECTRODE; POTASSIUM CONDUCTANCE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0032415114     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.6.g1274     Document Type: Article

References (22)

1. 29 cells. Pflügers Arch. 421:403-405, 1992.
2. K8 cardiac potassium channel. Nature 384:78-80, 1996.
3. Berschneider, H. M., M. R. Knowles, R. G. Azizkhan, R. C. Boucher, N. A. Tobey, R. C. Orlando, and D. W. Powell. Altered intestinal chloride transport in cystic fibrosis. FASEB J. 2:2625-2629, 1988.
4. + channel blocker 293B. Pflügers Arch. 434:499-501, 1997.
5. + and non-selective cation channels in the basolateral membrane of rat colonic crypt base cells. Pflügers Arch. 432:1011-1022, 1996.
6. Böhme, M., M. Diener, and W. Rummel. Calcium- and cyclic-AMP-mediated secretory responses in isolated colonie crypts. Pflügers Arch. 419:144-151, 1991.
7. Busch, A. E., G. L. Busch, E. Ford, H. Suessbrich, H. J. Lang, R. Greger, K. Kunzelmann, B. Attali, and W. Stühmer. The role of the IsK protein in the specific pharmacological properties of the IKs channel complex. Br. J. Pharmacol. 122:187-189, 1997.
8. Butterfield, I., G. Warhurst, M. N. Jones, and G. I. Sandle. Characterization of apical potassium channels induced in rat distal colon during potassium adaptation. J. Physiol. (Lond.) 501:537-547, 1997.
9. Ecke, D., M. Bleich, B. Schwartz, G. Fraser, and R. Greger. The ion conductances of colonie crypts from dexamethasone-treated rats. Pflügers Arch. 431:419-426, 1996.
10. Foster, E. S., G. I. Sandle, J. P. Hayslett, and H. J. Binder. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14):G619-G626, 1986.
11. - secretion is absent in cystic fibrosis. Gastroenterology 107:950-956, 1994.
12. Goodchild, M. C., and J. A. Dodge. Cystic Fibrosis: Manual of Diagnosis and Management. Surrey, UK: Biddies, 1986,
13. Greger, R., M. Bleich, J. Leipziger, D. Ecke, M. Mall, and K. Kunzelmann. Regulation of ion transport in colonie crypts. News Physiol. Sci. 12:62-66, 1997.
14. Grubb, B. R., and S. E. Gabriel. Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36):G258-G266, 1997.
15. Hardcastle, J., P. T. Hardcastle, C. J. Taylor, and J. Goldhill. Failure of cholinergic stimulation to induce a secretory response from the rectal mucosa in cystic fibrosis. Gut 32:1035-1039, 1991.
16. Jia, Y., C. J. Mathews, and J. W. Hanrahan. Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. J. Biol. Chem. 272:4978-4984, 1997.
17. - conductances in mouse choroid plexus epithelial cells do not require CFTR expression. Am. J. Physiol. 272 (Cell Physiol. 41):C1899-C1907, 1997.
18. - current in choroid plexus epithelial cells isolated from the rat. J. Physiol. (Lond.) 496:69-80, 1996.
19. - secretion from both crypts and surface epithelia of rat intestine. Am. J. Physiol. 264 (Cell Physiol. 33):C1294-C1301, 1993.
20. 29 cells: ion selectivity, additivity and stilbene sensitivity. Pflügers Arch. 421:447-454, 1992.
21. + conductance. Pflügers Arch. 429:517-530, 1995.
22. + conductances are located predominantly in surface cells in rat distal colon. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29):G71-G82, 1994.