The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl- conductance of Xenopus oocytes

Pflugers Archiv European Journal of Physiology

Volumn 435, Issue 1, 1997, Pages 178-181

  Kunzelmann, K ^a   Mall, M ^a   Briel, M ^a   Hipper, A ^a   Nitschke, R ^a   Ricken, S ^a   Greger, R ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Ca2+; CF; CFTR; Chloride channels; Ionomycin; Xenopus oocytes

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; CALCIUM ION; CHLORIDE CHANNEL; CYCLIC AMP; IONOMYCIN; ISOBUTYLMETHYLXANTHINE; TAMOXIFEN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CHLORIDE CONDUCTANCE; MEMBRANE CONDUCTANCE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; REGULATORY MECHANISM; XENOPUS LAEVIS;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CALCIUM; CHLORIDE CHANNELS; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTRIC CONDUCTIVITY; FEMALE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; IONOMYCIN; OOCYTES; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0031418039     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050498     Document Type: Article

References (18)

1. 29 cells. Pflügers Arch 421: 403-405
2. Bradbury NA, Jilling T, Kirk KL, Bridges RJ (1992) Regulated endocytosis in a chloride secretory epithelial cell line. Am J Physiol 262:C752-C759
3. Clarke LL, Grubb BR, Yankaskas JR, Cotton CU, McKenzie A, Boucher RC (1994) Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level didease in cftr (-/-) mice. Proc Natl Acad Sci 91:479-483
4. 2+ in Cl-secreting epithelial cells. Proc Natl Acad Sci 87:4956-4960
5. Cunningham SA, Worrell RT, Benos DJ, Frizzell RA (1992) cAMP-stimulated ion currents in xenopus oocytes expressing CFTR cRNA. Am J Physiol 262:C783-C788
6. Gray MA, Winpenny JP, Porteous DJ, Dorin JR, Argent BE (1994) CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am J Physiol 266:C213-C221
7. - secretion in nasal epithelia of CF mice. Am J Physiol 266:C1478-C1483
8. 29 cells: ion selectivity, additivity and stilbene sensitivity. Pflügers Arch 421:447-454
9. Kunzelmann K, Kiser G, Schreiber R, Riordan JR (1997) Inhibition of epithelial sodium currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator. FEBS Letters 400:341-344
10. - conductance in the oviduct is defective in mouse model of cystic fibrosis. Am J Physiol 268:C708-C712
11. Mall M, Hipper A, Greger R, Kunzelmann K (1996) Wilde type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes. FEBS 381:47-52
12. Mall M, Kunzelmann K, Hipper A, Busch AE, Greger R (1996) cAMP stimulation of CFTR expressing Xenopus oocytes activates a chromanol inhibitable K+ conductance. Pflügers Arch 432:516-522
13. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Plavsic SLN, Chou J, Drumm ML, Iannuzzi CM, Collins FS, Tsui L (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066-1072
14. - free medium. Biochem and Biophys Res Com 227:755-761
15. Schreiber R, Greger R, Kunzelmann K (1997) Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes. Pflügers Arch (in press)
16. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science Vol.269:847-850
17. - channel. Am J Physiol 271:C1887-C1894
18. Winpenny JP, Verdon B, McAlroy HL, Colledge WH, Ratcliff R. Evans MJ, Gray MA, Argent BE (1995) Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF mice. Pflügers Arch 430:26-33