메뉴 건너뛰기




Volumn 633, Issue 2, 2007, Pages 117-125

Trifluoperazine stimulates ionizing radiation induced cell killing through inhibition of DNA repair

Author keywords

Double strand break (DSB) repair; Field inversion gel electrophoresis (FIGE); Ionizing radiation (IR); Micronucleus (MN); Trifluoperazine (TFP)

Indexed keywords

CAFFEINE; DNA; HYDROGEN PEROXIDE; PHENOTHIAZINE DERIVATIVE; TRIFLUOPERAZINE; WORTMANNIN;

EID: 34547781893     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.05.011     Document Type: Article
Times cited : (18)

References (45)
  • 1
    • 0021888013 scopus 로고
    • The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation
    • Radford I.R. The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 48 1 (1985) 45-54
    • (1985) Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. , vol.48 , Issue.1 , pp. 45-54
    • Radford, I.R.1
  • 2
    • 0026347249 scopus 로고
    • Significance and measurement of DNA double-strand breaks in mammalian cells
    • Elia M.C., Deluca J.G., and Bradley M.O. Significance and measurement of DNA double-strand breaks in mammalian cells. Pharmacol. Ther. 51 3 (1991) 291-327
    • (1991) Pharmacol. Ther. , vol.51 , Issue.3 , pp. 291-327
    • Elia, M.C.1    Deluca, J.G.2    Bradley, M.O.3
  • 3
    • 0026303274 scopus 로고
    • The role of DNA double-strand breaks in ionizing radiation-induced killing of eukaryotic cells
    • Iliakis G. The role of DNA double-strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays 13 12 (1991) 641-648
    • (1991) Bioessays , vol.13 , Issue.12 , pp. 641-648
    • Iliakis, G.1
  • 4
    • 26844545414 scopus 로고    scopus 로고
    • The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism
    • Pajonk F., Ophoven A.V., Weissenberger C., et al. The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism. BMC Cancer 5 1 (2005) 76
    • (2005) BMC Cancer , vol.5 , Issue.1 , pp. 76
    • Pajonk, F.1    Ophoven, A.V.2    Weissenberger, C.3
  • 5
    • 0036827964 scopus 로고    scopus 로고
    • A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation
    • Kim C.H., Park S.J., and Lee S.H. A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation. J. Pharmacol. Exp. Ther. 303 2 (2002) 753-759
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , Issue.2 , pp. 753-759
    • Kim, C.H.1    Park, S.J.2    Lee, S.H.3
  • 6
    • 0028038823 scopus 로고
    • Cytotoxic and genetic effects of X-irradiation of human cells in the presence of chlorpromazine
    • Karmakar P., Dasgupta U.B., and Podder R.K. Cytotoxic and genetic effects of X-irradiation of human cells in the presence of chlorpromazine. Mutat. Res. 321 3 (1994) 159-164
    • (1994) Mutat. Res. , vol.321 , Issue.3 , pp. 159-164
    • Karmakar, P.1    Dasgupta, U.B.2    Podder, R.K.3
  • 7
    • 0020591753 scopus 로고
    • Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine
    • Ganapathi R., and Grabowski D. Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine. Cancer Res. 43 8 (1983) 3696-3699
    • (1983) Cancer Res. , vol.43 , Issue.8 , pp. 3696-3699
    • Ganapathi, R.1    Grabowski, D.2
  • 8
    • 0023225318 scopus 로고
    • Potentiation of sensitivity to bleomycin and the drug-induced DNA damage in EMT6 cells by calmodulin inhibitor trifluoperazine
    • Smith P.J., Mircheva J.J., and Bleechen N.M. Potentiation of sensitivity to bleomycin and the drug-induced DNA damage in EMT6 cells by calmodulin inhibitor trifluoperazine. Acta Physiol. Pharmacol. Bulg. 13 1 (1987) 41-45
    • (1987) Acta Physiol. Pharmacol. Bulg. , vol.13 , Issue.1 , pp. 41-45
    • Smith, P.J.1    Mircheva, J.J.2    Bleechen, N.M.3
  • 9
    • 0019123787 scopus 로고
    • Damage of cellular functions by trifluoperazine, a calmodulin-specific drug
    • Osborn M., and Weber K. Damage of cellular functions by trifluoperazine, a calmodulin-specific drug. Exp. Cell. Res. 130 2 (1980) 484-488
    • (1980) Exp. Cell. Res. , vol.130 , Issue.2 , pp. 484-488
    • Osborn, M.1    Weber, K.2
  • 10
    • 0033621288 scopus 로고    scopus 로고
    • Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling
    • Kang U.G., Kim M.J., Suh P.G., et al. Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling. Mol. Cell. 9 6 (1999) 596-602
    • (1999) Mol. Cell. , vol.9 , Issue.6 , pp. 596-602
    • Kang, U.G.1    Kim, M.J.2    Suh, P.G.3
  • 11
    • 0343374101 scopus 로고
    • N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation
    • Hidaka H., Sasaki Y., Tanaka T., et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 78 7 (1981) 4354-4357
    • (1981) Proc. Natl. Acad. Sci. U.S.A. , vol.78 , Issue.7 , pp. 4354-4357
    • Hidaka, H.1    Sasaki, Y.2    Tanaka, T.3
  • 12
    • 0022343334 scopus 로고
    • Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists
    • Hait W.N., and Lee G.L. Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists. Biochem. Pharmacol. 34 22 (1985) 3973-3978
    • (1985) Biochem. Pharmacol. , vol.34 , Issue.22 , pp. 3973-3978
    • Hait, W.N.1    Lee, G.L.2
  • 13
    • 0035976384 scopus 로고    scopus 로고
    • Induction of apoptosis by phenothiazine derivatives in V79 cells
    • Karmakar P., Natarajan A.T., Podder R.K., et al. Induction of apoptosis by phenothiazine derivatives in V79 cells. Toxicol. Lett. 125 1-3 (2001) 19-28
    • (2001) Toxicol. Lett. , vol.125 , Issue.1-3 , pp. 19-28
    • Karmakar, P.1    Natarajan, A.T.2    Podder, R.K.3
  • 14
    • 0035878747 scopus 로고    scopus 로고
    • Inhibition of DNA replication by tirapazamine
    • Peters K.B., Wang H., Brown J.M., et al. Inhibition of DNA replication by tirapazamine. Cancer Res. 61 14 (2001) 5425-5431
    • (2001) Cancer Res. , vol.61 , Issue.14 , pp. 5425-5431
    • Peters, K.B.1    Wang, H.2    Brown, J.M.3
  • 15
    • 0036007541 scopus 로고    scopus 로고
    • Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53
    • Sullivan G.F., Garcia-Welch A., White E., et al. Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53. J. Exp. Ther. Oncol. 2 1 (2002) 19-26
    • (2002) J. Exp. Ther. Oncol. , vol.2 , Issue.1 , pp. 19-26
    • Sullivan, G.F.1    Garcia-Welch, A.2    White, E.3
  • 16
    • 0023904582 scopus 로고
    • Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent
    • Hait W.N., Lazo J.S., Chen D.L., et al. Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent. J. Natl. Cancer. Inst. 80 4 (1988) 246-250
    • (1988) J. Natl. Cancer. Inst. , vol.80 , Issue.4 , pp. 246-250
    • Hait, W.N.1    Lazo, J.S.2    Chen, D.L.3
  • 17
    • 0024592461 scopus 로고
    • Phase I trial of combined therapy with bleomycin and the calmodulin antagonist, trifluoperazine
    • Hait W.N., Morris S., Lazo J.S., et al. Phase I trial of combined therapy with bleomycin and the calmodulin antagonist, trifluoperazine. Cancer Chemother. Pharmacol. 23 6 (1989) 358-362
    • (1989) Cancer Chemother. Pharmacol. , vol.23 , Issue.6 , pp. 358-362
    • Hait, W.N.1    Morris, S.2    Lazo, J.S.3
  • 18
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end joining
    • Lieber M.R., Ma Y., Pannicke U., et al. Mechanism and regulation of human non-homologous DNA end joining. Nat. Rev. Mol. Cell. Biol. 4 9 (2003) 712-720
    • (2003) Nat. Rev. Mol. Cell. Biol. , vol.4 , Issue.9 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3
  • 19
    • 0030814125 scopus 로고    scopus 로고
    • Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay
    • Rosenzweig K.E., Youmell M.B., Palayoor S.T., et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin. Cancer Res. 3 7 (1997) 1149-1156
    • (1997) Clin. Cancer Res. , vol.3 , Issue.7 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3
  • 20
    • 0032916940 scopus 로고    scopus 로고
    • Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks
    • Chernikova S.B., Wells R.L., and Elkind M.M. Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat. Res. 151 2 (1999) 159-166
    • (1999) Radiat. Res. , vol.151 , Issue.2 , pp. 159-166
    • Chernikova, S.B.1    Wells, R.L.2    Elkind, M.M.3
  • 21
    • 0027304013 scopus 로고
    • V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder
    • Hsieh C.L., Arlett C.F., and Lieber M.R. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J. Biol. Chem. 268 27 (1993) 20105-20109
    • (1993) J. Biol. Chem. , vol.268 , Issue.27 , pp. 20105-20109
    • Hsieh, C.L.1    Arlett, C.F.2    Lieber, M.R.3
  • 22
    • 0034548910 scopus 로고    scopus 로고
    • Cisplatin-DNA adducts inhibit translocation of the KU subunits of DNA-PK
    • Turuchi J.J., Karen M.H., and Zhou Y. Cisplatin-DNA adducts inhibit translocation of the KU subunits of DNA-PK. Nucleic Acids Res. 28 23 (2000) 4634-4641
    • (2000) Nucleic Acids Res. , vol.28 , Issue.23 , pp. 4634-4641
    • Turuchi, J.J.1    Karen, M.H.2    Zhou, Y.3
  • 23
    • 0034810574 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is inhibited by trifluoperazine
    • Eriksson A., Yachnin J., Lewensohn R., et al. DNA-dependent protein kinase is inhibited by trifluoperazine. Biochem. Biophys. Res. Commun. 283 4 (2001) 726-731
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , Issue.4 , pp. 726-731
    • Eriksson, A.1    Yachnin, J.2    Lewensohn, R.3
  • 24
    • 0021987630 scopus 로고
    • Measurement of micronuclei in lymphocytes
    • Fenech M., and Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147 1/2 (1985) 29-36
    • (1985) Mutat. Res. , vol.147 , Issue.1-2 , pp. 29-36
    • Fenech, M.1    Morley, A.A.2
  • 25
    • 34248213011 scopus 로고    scopus 로고
    • Direct effects of caffeine on osteoblastic cells metabolism: the possible casual effect of caffeine on the formation of osteoporesis
    • Tsuang Y.-H., Sun J.-S., Chen L.-T., et al. Direct effects of caffeine on osteoblastic cells metabolism: the possible casual effect of caffeine on the formation of osteoporesis. J. Orthop. Surg. Res. 1 7 (2006) 186-194
    • (2006) J. Orthop. Surg. Res. , vol.1 , Issue.7 , pp. 186-194
    • Tsuang, Y.-H.1    Sun, J.-S.2    Chen, L.-T.3
  • 26
    • 0024421553 scopus 로고
    • CHEF electrophoresis, a sensitive technique for the determination of DNA double-strand breaks
    • Blocher D., Einspenner M., and Zajackowski J. CHEF electrophoresis, a sensitive technique for the determination of DNA double-strand breaks. Int. J. Radiat. Biol. 56 4 (1989) 437-448
    • (1989) Int. J. Radiat. Biol. , vol.56 , Issue.4 , pp. 437-448
    • Blocher, D.1    Einspenner, M.2    Zajackowski, J.3
  • 27
    • 0025335271 scopus 로고
    • Measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis
    • Ager D.D., Dewey W.C., Gardiner K., et al. Measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis. Radiat. Res. 122 2 (1990) 181-187
    • (1990) Radiat. Res. , vol.122 , Issue.2 , pp. 181-187
    • Ager, D.D.1    Dewey, W.C.2    Gardiner, K.3
  • 28
    • 0026709051 scopus 로고
    • A fourth complementation group among ionizing radiation-sensitive Chinese hamster cell mutants defective in DNA double-strand break repair
    • Zdzienicka M.Z., Van W.N., and Van D.S.G.P. A fourth complementation group among ionizing radiation-sensitive Chinese hamster cell mutants defective in DNA double-strand break repair. Radiat. Res. 131 3 (1992) 309-314
    • (1992) Radiat. Res. , vol.131 , Issue.3 , pp. 309-314
    • Zdzienicka, M.Z.1    Van, W.N.2    Van, D.S.G.P.3
  • 29
    • 0027299912 scopus 로고
    • Field-inversion gel electrophoresis analysis of the induction and rejoining of DNA double-strand breaks in cells embedded in agarose
    • Kysela B.P., Michael B.D., and Arrand J.E. Field-inversion gel electrophoresis analysis of the induction and rejoining of DNA double-strand breaks in cells embedded in agarose. Radiat. Res. 134 1 (1993) 107-111
    • (1993) Radiat. Res. , vol.134 , Issue.1 , pp. 107-111
    • Kysela, B.P.1    Michael, B.D.2    Arrand, J.E.3
  • 30
    • 0029803485 scopus 로고    scopus 로고
    • Wortmannin is a potent inhibitor DNA double strand break but not single strand break repair in Chinese hamster ovary cells
    • Boulton S., Kyle S., Yalcintepe L., and Durkacz B.W. Wortmannin is a potent inhibitor DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis 17 11 (1996) 2285-2290
    • (1996) Carcinogenesis , vol.17 , Issue.11 , pp. 2285-2290
    • Boulton, S.1    Kyle, S.2    Yalcintepe, L.3    Durkacz, B.W.4
  • 31
    • 2342459790 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis
    • Chris J.N., and Boris Z. DNA damage-induced apoptosis. Oncogene 23 16 (2004) 2797-2808
    • (2004) Oncogene , vol.23 , Issue.16 , pp. 2797-2808
    • Chris, J.N.1    Boris, Z.2
  • 32
    • 0029313915 scopus 로고    scopus 로고
    • Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis
    • Smith M.L., and Fornace Jr. A.J. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutat. Res. 340 2/3 (1996) 109-124
    • (1996) Mutat. Res. , vol.340 , Issue.2-3 , pp. 109-124
    • Smith, M.L.1    Fornace Jr., A.J.2
  • 33
    • 0035796042 scopus 로고    scopus 로고
    • Homologous recombinational repair of DNA ensures mammalian chromosome stability
    • Thompson L.H., and Schild D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res. 477 1/2 (2001) 131-153
    • (2001) Mutat. Res. , vol.477 , Issue.1-2 , pp. 131-153
    • Thompson, L.H.1    Schild, D.2
  • 34
    • 0034031137 scopus 로고    scopus 로고
    • DNA double strand break repair in mammalian cells
    • Karran P. DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev. 10 2 (2000) 144-150
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , Issue.2 , pp. 144-150
    • Karran, P.1
  • 35
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • Van G.D.C., Hoeijmakers J.H., and Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2 3 (2001) 196-206
    • (2001) Nat. Rev. Genet. , vol.2 , Issue.3 , pp. 196-206
    • Van, G.D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 37
    • 0022001235 scopus 로고
    • Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists
    • Lazo J.S., Hait W.N., Kennedy K.A., et al. Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists. Mol. Pharmacol. 27 3 (1985) 387-393
    • (1985) Mol. Pharmacol. , vol.27 , Issue.3 , pp. 387-393
    • Lazo, J.S.1    Hait, W.N.2    Kennedy, K.A.3
  • 38
    • 0026662014 scopus 로고
    • Potentiation of cisplatin cytotoxicity in human ovarian carcinoma cell lines by trifluoperazine, a calmodulin inhibitor
    • Perez R.P., Handel L.M., and Hamilton T.C. Potentiation of cisplatin cytotoxicity in human ovarian carcinoma cell lines by trifluoperazine, a calmodulin inhibitor. Gynecol. Oncol. 46 1 (1992) 82-87
    • (1992) Gynecol. Oncol. , vol.46 , Issue.1 , pp. 82-87
    • Perez, R.P.1    Handel, L.M.2    Hamilton, T.C.3
  • 39
    • 0021911133 scopus 로고
    • Inhibition of DNA repair by trifluoperazine
    • Charp P.A., and Regan J.D. Inhibition of DNA repair by trifluoperazine. Biochim. Biophys. Acta 824 1 (1985) 34-39
    • (1985) Biochim. Biophys. Acta , vol.824 , Issue.1 , pp. 34-39
    • Charp, P.A.1    Regan, J.D.2
  • 40
    • 0035201216 scopus 로고    scopus 로고
    • In vivo association of Ku with mammalian origins of DNA replication
    • Novac O., Matheos D., Araujo F.D., et al. In vivo association of Ku with mammalian origins of DNA replication. Mol. Biol. Cell. 12 11 (2001) 3386-3401
    • (2001) Mol. Biol. Cell. , vol.12 , Issue.11 , pp. 3386-3401
    • Novac, O.1    Matheos, D.2    Araujo, F.D.3
  • 41
    • 3042838562 scopus 로고    scopus 로고
    • Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
    • Block W.D., Merkle D., Meek K., et al. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Res. 32 6 (2004) 1967-1972
    • (2004) Nucleic Acids Res. , vol.32 , Issue.6 , pp. 1967-1972
    • Block, W.D.1    Merkle, D.2    Meek, K.3
  • 42
    • 0034733925 scopus 로고    scopus 로고
    • Calmodulin antagonists and cAMP inhibit ionizing-radiation-enhancement of double-strand-break repair in human cells
    • Wang Y., Mallya S.M., and Sikpi M.O. Calmodulin antagonists and cAMP inhibit ionizing-radiation-enhancement of double-strand-break repair in human cells. Mutat. Res. 460 1 (2000) 29-39
    • (2000) Mutat. Res. , vol.460 , Issue.1 , pp. 29-39
    • Wang, Y.1    Mallya, S.M.2    Sikpi, M.O.3
  • 43
    • 3042791448 scopus 로고    scopus 로고
    • Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity
    • Bugreev D.V., and Mazin A.V. Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity. Proc. Natl. Acad. Sci. U.S.A. 101 27 (2004) 9988-9993
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.27 , pp. 9988-9993
    • Bugreev, D.V.1    Mazin, A.V.2
  • 44
    • 0033020393 scopus 로고    scopus 로고
    • A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids
    • Pantazaki A.A., and Lialiaris T.S. A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids. Mutagenesis 14 2 (1999) 243-248
    • (1999) Mutagenesis , vol.14 , Issue.2 , pp. 243-248
    • Pantazaki, A.A.1    Lialiaris, T.S.2
  • 45
    • 33645468792 scopus 로고    scopus 로고
    • Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane
    • Savino III J.A., Evans J.F., Rabinowitz D., et al. Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane. Mol. Cancer Ther. 5 3 (2006) 556-563
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.3 , pp. 556-563
    • Savino III, J.A.1    Evans, J.F.2    Rabinowitz, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.