Aggregation stability of a monoclonal antibody during downstream processing

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 1884-1894

  Arosio, Paolo ^a   Barolo, Giuliano ^a   Müller Späth, Thomas ^a   Wu, Hua ^a   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

aggregation; antibody; FFF; oligomer distribution; SEC

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; OLIGOMER; SODIUM CHLORIDE;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; DRUG STABILITY; FIELD FLOW FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; IMMUNOGLOBULIN AGGREGATE; LIGHT SCATTERING; PH; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

ANTIBODIES, MONOCLONAL; BUFFERS; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DRUG STABILITY; FRACTIONATION, FIELD FLOW; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; KINETICS; PROTEIN CONFORMATION; SODIUM CHLORIDE; SOLUTIONS;

EID: 79961171409     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0416-7     Document Type: Article

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