Characterization and analysis of thermal denaturation of antibodies by size exclusion high-performance liquid chromatography with quadruple detection

Analytical Biochemistry

Volumn 325, Issue 2, 2004, Pages 227-239

  Hartmann, Wanda K ^a   Saptharishi, Nirmala ^a   Yang, Xiao Yi ^a   Mitra, Gautam ^a   Soman, Gopalan ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

Intrinsic viscosity; Light scattering; Online SE HPLC; Protein aggregation kinetics; Refractometry; Stability; Thermal denaturation

Indexed keywords

AGGREGATES; CHEMICAL DETECTION; CONVERGENCE OF NUMERICAL METHODS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MOLECULAR WEIGHT; MONOCLONAL ANTIBODIES; REFRACTIVE INDEX; ULTRAVIOLET VISIBLE SPECTROSCOPY; VISCOSITY MEASUREMENT;

INTRINSIC VISCOSITY; ONLINE SE-HPLC; PROTEIN AGGREGATION; REFRACTOMETRY; THERMAL DENATURATIONS;

SIZE EXCLUSION CHROMATOGRAPHY;

CHIMERIC ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; OVALBUMIN;

ANALYTIC METHOD; ARTICLE; GEL FILTRATION; GEL PERMEATION CHROMATOGRAPHY; HEAT TREATMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MOLECULAR SIZE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; PROTEIN DENATURATION; REFRACTION INDEX; REFRACTOMETRY; SPECIES DIFFERENCE; TEMPERATURE SENSITIVITY; ULTRAVIOLET RADIATION; VISCOMETER;

MURINAE;

EID: 1642456636     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2003.10.031     Document Type: Article

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