Protein aggregation kinetics during Protein A chromatography. Case study for an Fc fusion protein

Journal of Chromatography A

Volumn 1171, Issue 1-2, 2007, Pages 22-28

  Shukla, Abhinav A ^a   Gupta, Priyanka ^a   Han, Xuejun ^a  

^a AMGEN INC   (United States)

Author keywords

Aggregation; Fc fusion protein; Kinetics; Protein A chromatography; Stabilizers

Indexed keywords

AGGLOMERATION; MONOCLONAL ANTIBODIES; PH EFFECTS; PROTEINS; PURIFICATION; REACTION KINETICS; STABILIZERS (AGENTS);

AGGREGATE FORMATION; FC FUSION PROTEIN; HIGHER ORDER REACTION; PROTEIN A CHROMATOGRAPHY;

CHROMATOGRAPHY;

BUFFER; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; PROTEIN A; UREA;

ARTICLE; CHROMATOGRAPHY; KINETICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS;

ALGORITHMS; ANIMALS; ANTIBODIES, MONOCLONAL; BUFFERS; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; IMMUNOGLOBULIN FC FRAGMENTS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN DENATURATION; RECOMBINANT FUSION PROTEINS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STAPHYLOCOCCAL PROTEIN A; UREA;

EID: 35348823110     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.09.040     Document Type: Article

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