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Volumn 66, Issue 6, 2011, Pages 1041-1044

Frequency of genetic polymorphisms of PXR gene in the Brazilian population

Author keywords

Allelic distribution; Brazilian population; Genetic variation; Pharmacogenetics

Indexed keywords

CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; PREGNANE X RECEPTOR; STEROID RECEPTOR;

EID: 79961164231     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322011000600020     Document Type: Article
Times cited : (9)

References (23)
  • 1
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • doi: 10.1016/S0165-6147(99)01363-2
    • Ingelman-Sundberg M, Oscarson M, McLellan RA. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol Sci. 1999;20:342-349, doi: 10.1016/S0165-6147(99)01363-2.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 2
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method
    • doi: 10.1097/00008571-200007000-00001
    • Ozdemir V, Kalow W, Tang BK, Paterson AD, Walker SE, Endrenyi L, et al. Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics. 2000;10:373-388, doi: 10.1097/00008571-200007000-00001.
    • (2000) Pharmacogenetics , vol.10 , pp. 373-388
    • Ozdemir, V.1    Kalow, W.2    Tang, B.K.3    Paterson, A.D.4    Walker, S.E.5    Endrenyi, L.6
  • 3
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • doi: 10.1126/science.286.5439.487
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science. 1999;286:487-491, doi: 10.1126/science.286.5439.487.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 4
    • 37549010733 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    • doi: 10.1124/dmd.107.016600
    • Lamba J, Lamba V, Strom S, Venkataramanan R, Schuetz E. Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression. Drug Metab Dispos. 2008;36:169-181, doi: 10.1124/dmd.107.016600.
    • (2008) Drug Metab Dispos , vol.36 , pp. 169-181
    • Lamba, J.1    Lamba, V.2    Strom, S.3    Venkataramanan, R.4    Schuetz, E.5
  • 5
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • doi: 10.1093/jnci/90.16.1225
    • Rebbeck TR, Jaffe JM, Walker AH, Wein AJ, Malkowicz SB. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst. 1998;90:1225-1229, doi: 10.1093/jnci/90.16.1225.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3    Wein, A.J.4    Malkowicz, S.B.5
  • 6
    • 0032825907 scopus 로고    scopus 로고
    • Population distribution and effects on drug metabolism of a genetic variant in the 59 promoter region of CYP3A4
    • doi: 10.1016/S0009-9236(99)70037-8
    • Ball SE, Scatina J, Kao J, Ferron GM, Fruncillo R, Mayer P, et al. Population distribution and effects on drug metabolism of a genetic variant in the 59 promoter region of CYP3A4. Clin Pharmacol Ther. 1999;66:288-294, doi: 10.1016/S0009-9236(99)70037-8.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 288-294
    • Ball, S.E.1    Scatina, J.2    Kao, J.3    Ferron, G.M.4    Fruncillo, R.5    Mayer, P.6
  • 7
    • 0034959461 scopus 로고    scopus 로고
    • Identification and functional characterization of eight CYP3A4 protein variants
    • doi: 10.1097/00008571-200107000-00008
    • Eiselt R, Domanski TL, Zibat A, Mueller R, Presecan-Siedel E, Hustert E, et al. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics. 2001;11:447-458, doi: 10.1097/00008571-200107000-00008.
    • (2001) Pharmacogenetics , vol.11 , pp. 447-458
    • Eiselt, R.1    Domanski, T.L.2    Zibat, A.3    Mueller, R.4    Presecan-Siedel, E.5    Hustert, E.6
  • 8
    • 13144260727 scopus 로고    scopus 로고
    • Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
    • doi: 10.1073/pnas.95.21.12208
    • Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow- Backman M, et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998;95:12208-12213, doi: 10.1073/pnas.95.21.12208.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 12208-12213
    • Bertilsson, G.1    Heidrich, J.2    Svensson, K.3    Asman, M.4    Jendeberg, L.5    Sydow-Backman, M.6
  • 9
    • 0032498303 scopus 로고    scopus 로고
    • An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
    • doi: 10.1016/S0092-8674(00)80900-9
    • Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998;92:73-82, doi: 10.1016/S0092-8674(00)80900-9.
    • (1998) Cell , vol.92 , pp. 73-82
    • Kliewer, S.A.1    Moore, J.T.2    Wade, L.3    Staudinger, J.L.4    Watson, M.A.5    Jones, S.A.6
  • 10
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • doi: 10.1172/JCI3703
    • Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest. 1998;102:1016-1023, doi: 10.1172/JCI3703.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 11
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • doi: 10.1038/87912
    • Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med. 2001;7:584-590, doi: 10.1038/87912.
    • (2001) Nat Med , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 12
    • 0034785945 scopus 로고    scopus 로고
    • The human pregnane X receptor: Genomic structure and identification and functional characterization of natural allelic variants
    • doi: 10.1097/00008571-200110000-00003
    • Zhang J, Kuehl P, Green ED, Touchman JW, Watkins PB, Daly A, et al. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics. 2001;11:555-572, doi: 10.1097/00008571-200110000-00003.
    • (2001) Pharmacogenetics , vol.11 , pp. 555-572
    • Zhang, J.1    Kuehl, P.2    Green, E.D.3    Touchman, J.W.4    Watkins, P.B.5    Daly, A.6
  • 13
    • 79961162442 scopus 로고    scopus 로고
    • Nuclear Receptor-Mediated Induction of CYP450 by Antiretrovirals: Functional Consequences of NR1I2 (PXR) Polymorphisms and Differential Prevalence in Whites and Sub-Saharan Africans
    • Svard J, Spiers JP, Mulcahy F, Hennessy M. Nuclear Receptor-Mediated Induction of CYP450 by Antiretrovirals: Functional Consequences of NR1I2 (PXR) Polymorphisms and Differential Prevalence in Whites and Sub-Saharan Africans. J Acquir Immune Defic Syndr.
    • J Acquir Immune Defic Syndr
    • Svard, J.1    Spiers, J.P.2    Mulcahy, F.3    Hennessy, M.4
  • 14
    • 43449089787 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations
    • doi: 10.1159/000123687
    • Wang XD, Deng XY, Chen J, Li JL, Chen X, Zhao LZ, et al. Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations. Pharmacology. 2008;81:350-354, doi: 10.1159/000123687.
    • (2008) Pharmacology , vol.81 , pp. 350-354
    • Wang, X.D.1    Deng, X.Y.2    Chen, J.3    Li, J.L.4    Chen, X.5    Zhao, L.Z.6
  • 15
    • 36949014514 scopus 로고    scopus 로고
    • A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese
    • doi: 10.2174/138920007782798199
    • Wang XD, Li JL, Su QB, Deng XY, Lu Y, Chen J, et al. A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese. Curr Drug Metab. 2007;8:778-786, doi: 10.2174/138920007782798199.
    • (2007) Curr Drug Metab , vol.8 , pp. 778-786
    • Wang, X.D.1    Li, J.L.2    Su, Q.B.3    Deng, X.Y.4    Lu, Y.5    Chen, J.6
  • 17
    • 61549104490 scopus 로고    scopus 로고
    • PXR: A xenobiotic receptor of diverse function implicated in pharmacogenetics
    • doi: 10.2217/14622416.9.11.1695
    • Zhang B, Xie W, Krasowski MD. PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics. 2008;9:1695-1709, doi: 10.2217/14622416.9.11.1695.
    • (2008) Pharmacogenomics , vol.9 , pp. 1695-1709
    • Zhang, B.1    Xie, W.2    Krasowski, M.D.3
  • 18
    • 0034777488 scopus 로고    scopus 로고
    • Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
    • Hustert E, Zibat A, Presecan-Siedel E, Eiselt R, Mueller R, Fuss C, et al. Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. Drug Metab Dispos. 2001;29:1454-1459.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1454-1459
    • Hustert, E.1    Zibat, A.2    Presecan-Siedel, E.3    Eiselt, R.4    Mueller, R.5    Fuss, C.6
  • 19
    • 58149265463 scopus 로고    scopus 로고
    • PXR pharmacogenetics: Association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients
    • doi: 10.1158/1078-0432.CCR-08-0411
    • Sandanaraj E, Lal S, Selvarajan V, Ooi LL, Wong ZW, Wong NS, et al. PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients. Clin Cancer Res. 2008;14:7116-7126, doi: 10.1158/1078-0432.CCR-08-0411.
    • (2008) Clin Cancer Res , vol.14 , pp. 7116-7126
    • Sandanaraj, E.1    Lal, S.2    Selvarajan, V.3    Ooi, L.L.4    Wong, Z.W.5    Wong, N.S.6
  • 20
    • 53349160769 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C--.T) with reduced concentrations of unboosted atazanavir
    • doi: 10.1086/592304
    • Siccardi M, D'Avolio A, Baietto L, Gibbons S, Sciandra M, Colucci D, et al. Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C--.T) with reduced concentrations of unboosted atazanavir. Clin Infect Dis. 2008;47:1222-1225, doi: 10.1086/592304.
    • (2008) Clin Infect Dis , vol.47 , pp. 1222-1225
    • Siccardi, M.1    D'avolio, A.2    Baietto, L.3    Gibbons, S.4    Sciandra, M.5    Colucci, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.