Influence of cultivar and concentration of selected phenolic constituents on the in vitro chemiopreventive potential of olive oil extracts

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 15, 2011, Pages 8167-8174

  Fabiani, Roberto ^a   Sepporta, Maria V ^b   Mazza, Teresa ^a   Rosignoli, Patrizia ^a   Fuccelli, Raffaela ^a   De Bartolomeo, Angelo ^a   Crescimanno, Marilena ^b   Taticchi, Agnese ^a   Esposto, Sonia ^a   Servili, Maurizio ^a   Morozzi, Guido ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

apoptosis; cell cycle; chemoprevention; phenols; proliferation; virgin olive oil

Indexed keywords

ANTI-PROLIFERATIVE; CELL CYCLE; CHEMOPREVENTION; CHEMOPREVENTIVE; CHEMOPREVENTIVE ACTIVITY; CHEMOPREVENTIVE EFFECTS; COMPLEX MIXTURE; CULTURE MEDIUM; IN-VITRO; ISOLATED COMPOUNDS; LIGNANS; LOW CONCENTRATIONS; OLIVE OIL; PHENOLIC COMPOUNDS; PHENYL ALCOHOL; PROLIFERATION; SYNERGISTIC ACTION; TUMOR CELLS; VIRGIN OLIVE OIL;

CELL CULTURE; CELL DEATH; VEGETABLE OILS;

PHENOLS;

OLIVE OIL; PHENOL DERIVATIVE; PLANT EXTRACT; VEGETABLE OIL;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; NEOPLASM; OLIVE TREE; PATHOPHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; NEOPLASMS; OLEA; PHENOLS; PLANT EXTRACTS; PLANT OILS;

EID: 79961149234     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf201459u     Document Type: Article

References (33)

1. Waterman, E.; Lockwood, B. Active components and clinical applications of olive oil Altern. Med. Rev. 2007, 12, 331-342
2. Cicerale, S.; Conlan, X. A.; Sinclair, A. J.; Keast, R. S. J. Chemistry and health of olive oil phenolics Crit. Rev. Food Sci. Nutr. 2009, 49, 218-236
3. Servili, M.; Esposto, S.; Fabiani, R.; Urbani, S.; Taticchi, A.; Mariucci, F.; Selvaggini, R.; Montedoro, G. F. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure Inflammopharmacology 2009, 17, 1-9
4. Visioli, F.; Bellomo, G.; Galli, C. Free radical-scavenging properties of olive oil polyphenols Biochem. Biophys. Res. Commun. 1998, 247, 60-64 (Pubitemid 28412525)
5. Fabiani, R.; Rosignoli, P.; De Bartolomeo, A.; Fuccelli, R.; Servili, M.; Montedoro, G. F.; Morozzi, G. Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol and other olive phenolic compounds in human blood mononuclear cells and HL60 cells J. Nutr. 2008, 138, 1411-1416
6. Weinbrenner, T.; Fito, M.; de la Torre, R.; Saez, G. T.; Rijken, P.; Tormos, C.; Coolen, C.; Coolen, S.; Albaladejo, M. F.; Abanades, S.; Schroder, H.; Murrat, J.; Covas, M. I. Olive oil high in phenolic compounds modulate oxidative/antioxidative status in men J. Nutr. 2004, 134, 2314-2321 (Pubitemid 39201602)
7. Salvini, S.; Sera, F.; Caruso, D.; Giovannelli, L.; Visioli, F.; Saieva, C.; Masala, G.; Ceroti, M.; Giovacchini, V.; Pizzotti, V.; Galli, C.; Romani, A.; Mulinacci, N.; Bortolomeazzi, R.; Dolara, P.; Palli, D. Daily consumption of a high-phenol extra virgin olive oil reduces oxidative DNA damage in postmenopausal women Br. J. Nutr. 2006, 95, 742-751
8. Guichard, C.; Pedruzzi, E.; Fay, M.; Marie, J. C.; Braut-Boucher, F.; Daniel, F.; Grodet, A.; Gougerot-Pocidalo, M. A.; Chastre, E.; Kotelevets, L.; Lizard, G.; Vandewalle, A.; Driss, F.; Ogier-Denis, E. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells Carcinogenesis 2006, 27, 1812-1827 (Pubitemid 44288663)
9. Menendez, J. A.; Vazquez-Martin, A.; Colomer, R.; Brunet, J.; Carrasco-Pancorbo, A.; Garcia-Villalba, R.; Fernandez-Gutierrez, A.; Segura-Carretero, A. Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells BMC Cancer 2007, 7-80
10. Han, J.; Talorete, T. P. N.; Yamada, P.; Isoda, H. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells Cytotechnology 2009, 59, 45-53
11. Goulas, V.; Exarchou, V.; Troganis, A. N.; Psomiadou, E.; Fotsis, T.; Briasoulis, E.; Gerothanassis, P. Phytochemicals in olive oil-leaf extracts and their antiproliferative activity against cancer and endothelial cells Mol. Nutr. Food Res. 2009, 53, 600-608
12. Obied, H. K.; Prenzler, P. D.; Konczak, I.; Rehman, A.; Robards, K. Chemistry and bioactivity of olive biophenols in some antioxidant and antiproliferative in vitro bioassays Chem. Res. Toxicol. 2009, 22 (1) 227-234
13. D'Angelo, S.; Ingrosso, D.; Migliardi, V.; Sorrentino, A.; Donnarumma, G.; Baroni, A.; Masella, L.; Tufano, M. A.; Zappia, M.; Galletti, P. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells Free Radical Biol. Med. 2005, 38, 908-919 (Pubitemid 40321083)
14. Della Ragione, F. D.; Cucciolla, V.; Borriello, A.; Pietra, V. D.; Pontoni, G.; Racioppi, L.; Manna, C.; Galletti, P.; Zappia, V. Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis Biochem. Biophys. Res. Commun. 2000, 278, 733-739
15. Fabiani, R.; De Bartolomeo, A.; Rosignoli, P.; Servili, M.; Montedoro, G. F.; Morozzi, G. Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis Eur. J. Cancer Prev. 2002, 14, 351-358 (Pubitemid 34948203)
16. Fabiani, R.; Fuccelli, R.; Pieravanti, F.; De Bartolomeo, A.; Morozzi, G. Production of hydrogen peroxide is responsible for then induction of apoptosis on HL60 cells Mol. Nutr. Food Res. 2009, 53, 887-896
17. Fabiani, R.; Rosignoli, P.; De Bartolomeo, A.; Fuccelli, R.; Servili, M.; Morozzi, G. The production of hydrogen peroxide is not a common mechanism by which olive oil phenol compounds induce apoptosis on HL60 cells Food Chem. 2011, 125, 1249-1255
18. Servili, M.; Selvaggini, R.; Esposto, S.; Taticchi, A.; Montedoro, G. F.; Morozzi, G. Health and sensory properties of virgin olive oil hydrophilic phenols: agronomic and technological aspects of production that affect their occurrence in the oil J. Chromatogr., A 2004, 1054, 113-127 (Pubitemid 39445815)
19. Montedoro, G. F.; Servili, M.; Baldioli, M.; Selvaggini, R.; Miniati, E.; Macchioni, A. Simple and hydrolyzable compounds in virgin olive oil. 3. Spectroscopic characterizations of the secoiridoid derivatives J. Agric. Food Chem. 1993, 41, 2228-2234
20. Hussain, R. F.; Nouri, A. M.; Oliver, R. T. A new approach for measurement of cytotoxicity using colorimetric assay J. Immunol. Methods 1993, 160 (1) 89-96
21. Hoorens, A.; Van de Casteele, M.; Klöppel, G.; Pipeleers, D. Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program J. Clin. Invest. 1996, 98, 1568-1574 (Pubitemid 26327866)
22. Nourooz-Zadeh, J.; Tajaddini-Sarmadi, J.; Wolff, S. P. Measurement of plasma hydroperoxide concentration by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine Anal. Biochem. 1994, 220, 403-409
23. Fabiani, R.; De Bartolomeo, A.; Rosignoli, P.; Servili, M.; Selvaggini, R.; Montedoro, G. F.; Di Saverio, C.; Morozzi, G. Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation J. Nutr. 2006, 136, 614-619 (Pubitemid 43363744)
24. Beuchamp, G. K.; Keast, R. S. J.; Morel, D.; Lin, J.; Pika, J.; Han, Q.; Lee, C. H.; Smith, A. B.; Breslin, P. A. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil Nature 2005, 437, 45-46 (Pubitemid 41613421)
25. Subhashini, J.; Mahipal, S. V.; Reddanna, P. Anti-proliferative and apoptotic effects of celecoxib on human myeloid leukemia in vitro Cancer Lett. 2005, 224, 31-43 (Pubitemid 40720365)
26. Corona, G.; Deiana, M.; Incani, A.; Vauzour, D.; Dessì, M. A.; Spencer, J. P. E. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlines their anti-proliferative effects Biochem. Biophys. Res. Commun. 2007, 362, 606-611 (Pubitemid 47368135)
27. Joe, A. K.; Liu, H.; Suzui, M.; Vural, M. E.; Xiao, D.; Weinstein, I. B. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines Clin. Cancer Res. 2002, 8 (3) 893-903 (Pubitemid 34742123)
28. Fini, L.; Hotchkiss, E.; Fogliani, V.; Graziani, G.; Romano, M.; De Vol, E. B.; Qin, H.; Selgrad, M.; Boland, C. R.; Ricciardiello, L. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines Carcinogenesis 2008, 29, 139-146 (Pubitemid 351201752)
29. 2 during interaction of phenolic compounds with cell culture media J. Agric. Food Chem. 2002, 50, 3156-3160 (Pubitemid 34533616)
30. Liu, R. H.; Sun, J. Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation J. Agric. Food Chem. 2003, 51, 1718-1723
31. Menendez, J. A.; Vazquez-Martin, A.; Garcia-Villalba, R.; Carrasco-Pancorbo, A.; Oliveras-Ferraros, C.; Fernandez-Gutierrez, A.; Segura-Carretero, A. tabAnti-HER (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial extra-virgin olive oil (EVOO) BMC Cancer 2008, 8, 377
32. Wolf, D.; Rotter, V. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells Proc. Natl. Acad. Sci. U.S.A. 1985, 82, 790-794 (Pubitemid 15142764)
33. Lozano-Sánchez, J.; Segura-Carretero, A.; Menendez, J. A.; Oliveras-Ferraros, C.; Cerretani, L.; Fernández-Gutiérrez, A. Prediction of extra virgin olive oil varieties through their phenolic profile. Potential cytotoxic activity against human breast cancer cells J. Agric. Food Chem. 2010, 58 (18) 9942-9955