Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 30, 2011, Pages 12243-12248

  Yu, Miao ^a   Romer, Katherine A ^a   Nieland, Thomas J F ^a   Xu, Shangzhe ^a   Saenz Vash, Veronica ^a,b   Penman, Marsha ^a   Yesilaltay, Ayce ^a   Carr, Steven A ^a   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Chemical biology; Cholesterol; Disulfide; Lipoprotein

Indexed keywords

CELL PROTEIN; CELL PROTEIN BLT 1; CYSTEINE; SCAVENGER RECEPTOR BI; SERINE; SMALL MOLECULE INHIBITOR; THIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; ENDOCYTOSIS; EXOPLASM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LIPID TRANSPORT; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SENSITIVITY ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLOPENTANES; CYSTEINE; HUMANS; LIPID METABOLISM; LIPOPROTEINS, HDL; MASS SPECTROMETRY; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; RECOMBINANT PROTEINS; SCAVENGER RECEPTORS, CLASS B; THIOSEMICARBAZONES;

EID: 79961082934     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109078108     Document Type: Article

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