Protein kinase Cθ is a specific target for inhibition of the HIV type 1 replication in CD4 + T lymphocytes

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27363-27377

  López Huertas, María Rosa ^a   Mateos, Elena ^a   Díaz Gil, Gema ^b   Gómez Esquer, Francisco ^b   Del Cojo, María Sánchez ^a   Alcamí, José ^a   Coiras, Mayte ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; AUTOIMMUNE DISEASE; CATALYTIC DOMAINS; DOSE-DEPENDENT; HIGHLY ACTIVE ANTI-RETROVIRAL THERAPIES; IMMUNOSUPPRESSIVE AGENT; LIPID RAFT; PERIPHERAL BLOOD LYMPHOCYTES; POTENTIAL RISKS; PROTEIN KINASE C; SELECTIVE INHIBITION; T CELL ACTIVATION; T CELLS; T LYMPHOCYTES; VIRAL INFECTIONS; VIRAL REPLICATION;

CELL PROLIFERATION; ENZYMES; PHOSPHORYLATION;

CELLS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C DELTA; PROTEIN KINASE C THETA; PROTEIN KINASE C ZETA; ROTTLERIN; ACETOPHENONE DERIVATIVE; BENZOPYRAN DERIVATIVE; ISOENZYME; PRIMER DNA; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; LIPID RAFT; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION; CELL LINE; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY; VIRUS GENOME;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACETOPHENONES; BASE SEQUENCE; BENZOPYRANS; CATALYTIC DOMAIN; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA PRIMERS; GENOME, VIRAL; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRUS REPLICATION;

EID: 79960974038     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210443     Document Type: Article

References (78)

1. Meller, N., Altman, A., and Isakov, N. (1998) Stem Cells 16, 178-192
2. Baier, G., Telford, D., Giampa, L., Coggeshall, K. M., Baier-Bitterlich, G., Isakov, N., and Altman, A. (1993) J. Biol. Chem. 268, 4997-5004
3. Isakov, N., and Altman, A. (2002) Annu. Rev. Immunol. 20, 761-794
4. Altman, A., Isakov, N., and Baier, G. (2000) Immunol. Today 21, 567-573
5. Baier, G. (2003) Immunol. Rev. 192, 64-79
6. Liu, Y., Graham, C., Li, A., Fisher, R. J., and Shaw, S. (2002) Biochem. J. 361, 255-265
7. Newton, A. C. (2009) J. Lipid Res. 50, S266-S271
8. Gallegos, L. L., and Newton, A. C. (2008) IUBMB Life 60, 782-789
9. Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., and Dustin, M. L. (1999) Science 285, 221-227
10. Coudronniere, N., Villalba, M., Englund, N., and Altman, A. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 3394-3399
11. Dustin, M. L., and Chan, A. C. (2000) Cell 103, 283-294
12. Alcamí, J., Laín de Lera, T., Folgueira, L., Pedraza, M. A., Jacqué, J. M., Bachelerie, F., Noriega, A. R., Hay, R. T., Harrich, D., and Gaynor, R. B. (1995) EMBO J. 14, 1552-1560
13. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597
14. May, M. J., and Ghosh, S. (1998) Immunol. Today 19, 80-88
15. Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M. R., Ghattas, G., Brenchley, J. M., Schacker, T. W., Hill, B. J., Douek, D. C., Routy, J. P., Haddad, E. K., and Sékaly, R. P. (2009) Nat. Med. 15, 893-900
16. Chun, T. W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., Kuo, Y. H., Brookmeyer, R., Zeiger, M. A., Barditch-Crovo, P., and Siliciano, R. F. (1997) Nature 387, 183-188
17. Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., Gallant, J., Markowitz, M., Ho, D. D., Richman, D. D., and Siliciano, R. F. (1997) Science 278, 1295-1300
18. Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., and Richman, D. D. (1997) Science 278, 1291-1295
19. Walensky, R. P., Paltiel, A. D., Losina, E., Mercincavage, L. M., Schackman, B. R., Sax, P. E., Weinstein, M. C., and Freedberg, K. A. (2006) J. Infect. Dis. 194, 11-19
20. Coiras, M., López-Huertas, M. R., Pérez-Olmeda, M., and Alcamí, J. (2009) Nat. Rev. Microbiol. 7, 798-812
21. Rullas, J., Bermejo, M., García-Pérez, J., Beltán, M., González, N., Hezareh, M., Brown, S. J., and Alcamí, J. (2004) Antivir. Ther. 9, 545-554
22. Wender, P. A., Kee, J. M., and Warrington, J. M. (2008) Science 320, 649-652
23. Márquez, N., Calzado, M. A., Sánchez-Duffhues, G., Pérez, M., Minassi, A., Pagani, A., Appendino, G., Diaz, L., Muñoz-Fernández, M. A., and Muñoz, E. (2008) Biochem. Pharmacol. 75, 1370-1380
24. Bedoya, L. M., Márquez, N., Martínez, N., Gutiérrez-Eisman, S., Alvarez, A., Calzado, M. A., Rojas, J. M., Appendino, G., Muñoz, E., and Alcamí, J. (2009) Biochem. Pharmacol. 77, 965-978
25. Zack, J. A., Arrigo, S. J., Weitsman, S. R., Go, A. S., Haislip, A., and Chen, I. S. (1990) Cell 61, 213-222
26. Mehandru, S., Poles, M. A., Tenner-Racz, K., Horowitz, A., Hurley, A., Hogan, C., Boden, D., Racz, P., and Markowitz, M. (2004) J. Exp. Med. 200, 761-770
27. Brenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M., Haase, A. T., and Douek, D. C. (2004) J. Exp. Med. 200, 749-759
28. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., and Martin, M. A. (1986) J. Virol. 59, 284-291
29. Garcia-Perez, J., Sanchez-Palomino, S., Perez-Olmeda, M., Fernandez, B., and Alcami, J. (2007) J. Med. Virol. 79, 127-137
30. Bachelerie, F., Alcami, J., Arenzana-Seisdedos, F., and Virelizier, J. L. (1991) Nature 350, 709-712
31. Arenzana-Seisdedos, F., Fernandez, B., Dominguez, I., Jacqué, J. M., Thomas, D., Diaz-Meco, M. T., Moscat, J., and Virelizier, J. L. (1993) J. Virol. 67, 6596-6604
32. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J. L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J. M., Clark-Lewis, I., Legler, D. F., Loetscher, M., Baggiolini, M., and Moser, B. (1996) Nature 382, 833-835
33. Springael, C., Thomas, S., Rahmouni, S., Vandamme, A., Goldman, M., Willems, F., and Vosters, O. (2007) Biochem. Pharmacol. 73, 515-525
34. Gekeler, V., Boer, R., Uberall, F., Ise, W., Schubert, C., Utz, I., Hofmann, J., Sanders, K. H., Schächtele, C., Klemm, K., and Grunicke, H. (1996) Br. J. Cancer 74, 897-905
35. Villalba, M. (1998) Neuroreport 9, 1713-1717
36. Zhang, D., Anantharam, V., Kanthasamy, A., and Kanthasamy, A. G. (2007) J. Pharmacol. Exp. Ther. 322, 913-922
37. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
38. He, J., Choe, S., Walker, R., Di Marzio, P., Morgan, D. O., and Landau, N. R. (1995) J. Virol. 69, 6705-6711
39. Connor, R. I., Chen, B. K., Choe, S., and Landau, N. R. (1995) Virology 206, 935-944
40. Laín de Lera, T., Folgueira, L., Martín, A. G., Dargemont, C., Pedraza, M. A., Bermejo, M., Bonay, P., Fresno, M., and Alcami, J. (1999) Oncogene 18, 1581-1588
41. Meller, N., Elitzur, Y., and Isakov, N. (1999) Cell Immunol. 193, 185-193
42. López-Huertas, M. R., Callejas, S., Abia, D., Mateos, E., Dopazo, A., Alcamí, J., and Coiras, M. (2010) Nucleic Acids Res. 38, 3287-3307
43. Klein-Hitpass, L., Schorpp, M., Wagner, U., and Ryffel, G. U. (1986) Cell 46, 1053-1061
44. Sancho, R., Márquez, N., Gómez-Gonzalo, M., Calzado, M. A., Bettoni, G., Coiras, M. T., Alcamí, J., López-Cabrera, M., Appendino, G., and Muñoz, E. (2004) J. Biol. Chem. 279, 37349-37359
45. Folks, T. M., Powell, D., Lightfoote, M., Koenig, S., Fauci, A. S., Benn, S., Rabson, A., Daugherty, D., Gendelman, H. E., and Hoggan, M. D. (1986) J. Exp. Med. 164, 280-290
46. Solomou, E. E., Juang, Y. T., and Tsokos, G. C. (2001) J. Immunol. 166, 5665-5674
47. Rybin, V. O., Sabri, A., Short, J., Braz, J. C., Molkentin, J. D., and Steinberg, S. F. (2003) J. Biol. Chem. 278, 14555-14564
48. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
49. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., and Loriolle, F. (1991) J. Biol. Chem. 266, 15771-15781
50. Matlin, K. S., Reggio, H., Helenius, A., and Simons, K. (1982) J. Mol. Biol. 156, 609-631
51. Garcia-Perez, J., Rueda, P., Staropoli, I., Kellenberger, E., Alcami, J., Arenzana-Seisdedos, F., and Lagane, B. (2011) J. Biol. Chem. 286, 4978-4990
52. Ichimura, H., and Levy, J. A. (1995) Virology 211, 554-560
53. Sun, Z., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., and Littman, D. R. (2000) Nature 404, 402-407
54. Parmer, T. G., Ward, M. D., and Hait, W. N. (1997) Cell Growth Differ. 8, 327-334
55. Powell, J. D., Ragheb, J. A., Kitagawa-Sakakida, S., and Schwartz, R. H. (1998) Immunol. Rev. 165, 287-300
56. Williams, S. A., and Greene, W. C. (2007) Cytokine 39, 63-74
57. Deszo, E. L., Brake, D. K., Cengel, K. A., Kelley, K. W., and Freund, G. G. (2001) J. Biol. Chem. 276, 10212-10217
58. Gschwendt, M., Müller, H. J., Kielbassa, K., Zang, R., Kittstein, W., Rincke, G., and Marks, F. (1994) Biochem. Biophys. Res. Commun. 199, 93-98
59. Majumder, P. K., Pandey, P., Sun, X., Cheng, K., Datta, R., Saxena, S., Kharbanda, S., and Kufe, D. (2000) J. Biol. Chem. 275, 21793-21796
60. Ringshausen, I., Oelsner, M., Weick, K., Bogner, C., Peschel, C., and Decker, T. (2006) Leukemia 20, 514-520
61. Matteucci, C., Balestrieri, E., Macchi, B., and Mastino, A. (2004) J. Med. Virol. 74, 473-483
62. Okamoto, K., Fujisawa, J., Reth, M., and Yonehara, S. (2006) Genes Cells 11, 177-191
63. Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., and Crabtree, G. R. (1989) Science 246, 1617-1620
64. Berrey, M. M., Schacker, T., Collier, A. C., Shea, T., Brodie, S. J., Mayers, D., Coombs, R., Krieger, J., Chun, T. W., Fauci, A., Self, S. G., and Corey, L. (2001) J. Infect. Dis. 183, 1466-1475
65. Hoen, B., Dumon, B., Harzic, M., Venet, A., Dubeaux, B., Lascoux, C., Bourezane, Y., Ragnaud, J. M., Bicart-See, A., Raffi, F., Beauvais, L., Fleury, H., and Séréni, D. (1999) J. Infect. Dis. 180, 1342-1346
66. Oxenius, A., Price, D. A., Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, A. K., and Phillips, R. E. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 3382-3387
67. Pantaleo, G., Cohen, O. J., Schacker, T., Vaccarezza, M., Graziosi, C., Rizzardi, G. P., Kahn, J., Fox, C. H., Schnittman, S. M., Schwartz, D. H., Corey, L., and Fauci, A. S. (1998) Nat. Med. 4, 341-345
68. Pantaleo, G., Demarest, J. F., Schacker, T., Vaccarezza, M., Cohen, O. J., Daucher, M., Graziosi, C., Schnittman, S. S., Quinn, T. C., Shaw, G. M., Perrin, L., Tambussi, G., Lazzarin, A., Sekaly, R. P., Soudeyns, H., Corey, L., and Fauci, A. S. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 254-258
69. Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., Daucher, M. B., Cohen, O. J., Denis, F., Biddison, W. E., Sekaly, R. P., and Fauci, A. S. (1997) Eur. J. Immunol. 27, 3166-3173
70. Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., and Walker, B. D. (1997) Science 278, 1447-1450
71. Schacker, T., Collier, A. C., Hughes, J., Shea, T., and Corey, L. (1996) Ann. Intern. Med. 125, 257-264
72. Cywin, C. L., Dahmann, G., Prokopowicz, A. S., 3rd, Young, E. R., Magolda, R. L., Cardozo, M. G., Cogan, D. A., Disalvo, D., Ginn, J. D., Kashem, M. A., Wolak, J. P., Homon, C. A., Farrell, T. M., Grbic, H., Hu, H., Kaplita, P. V., Liu, L. H., Spero, D. M., Jeanfavre, D. D., O'Shea, K. M., White, D. M., Woska, J. R., Jr., and Brown, M. L. (2007) Bioorg. Med. Chem. Lett. 17, 225-230
73. Boschelli, D. H. (2009) Curr. Top. Med. Chem. 9, 640-654
74. Baier, G., and Wagner, J. (2009) Curr. Opin. Cell Biol. 21, 262-267
75. Boschelli, D. H., Subrath, J., Niu, C., Wu, B., Wang, Y., Lee, J., Brennan, A., Ho, M., Deng, B., Yang, X., Xu, X., Leung, L., Wang, J., Atherton, J., and Chaudhary, D. (2010) Bioorg. Med. Chem. Lett. 20, 1965-1968
76. Evenou, J. P., Wagner, J., Zenke, G., Brinkmann, V., Wagner, K., Kovarik, J., Welzenbach, K. A., Weitz-Schmidt, G., Guntermann, C., Towbin, H., Cottens, S., Kaminski, S., Letschka, T., Lutz-Nicoladoni, C., Gruber, T., Hermann-Kleiter, N., Thuille, N., and Baier, G. (2009) J. Pharmacol. Exp. Ther. 330, 792-801
77. Manicassamy, S. (2009) Curr. Opin. Investig Drugs 10, 1225-1235
78. Matz, M., Weber, U., Mashreghi, M. F., Lorkowski, C., Ladhoff, J., Kramer, S., Neumayer, H. H., and Budde, K. (2010) Nephrol. Dial. Transplant. 25, 2159-2167