Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells

World Journal of Gastroenterology

Volumn 6, Issue 2, 2000, Pages 295-297

  Huang, Pei Lin ^a,b,c   Zhu, Shi Neng ^b   Lu, Shi Lun ^b   Dai, Zhen Sheng ^a   Jin, Yue Lin ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CERULENIN; FATTY ACID SYNTHASE;

APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; DRUG INHIBITION; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL;

EID: 0033996516     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR, Kuhajda FP. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res, 1996;56:1189-1193
2. AloPL, Visca P, Marci A, Mangoni A, Botti C, Tondo UD. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer, 1996; 77: 474-482
3. Rashi A, Pizer ES, Moga M, Milgraum LZ, Zahurak M, Pasternack GR, Kuhajda FP, Hamilton SR. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol, 1997; 150: 201 -208
4. Shurbaji MS, Kalbfleisch JH, Thurmond TS. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol, 1996; 27: 917-921
5. Epstein JI, Carmichael M, Partin AW. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology, 1995; 45; 81-86
6. Omura S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev, 1976; 40:681-697
7. Funabashi H, Kawaguchi A, Tomkoda H, Omura S, Okuda S, Iwasaki S. Binding site of cerulenin in fatty acid synthetase. J Biochem, 1989;105;751-755
8. Kerr JFR, Winterford CM, Biol ADA, Harmon BV. Apoptosis: its significance in cancer and cancer therapy. Cancer, 1994;73: 2013-2026
9. Willams GT. Programmed cell death; apoptosis and oncogenesis. Cell, 1991; 65:1097-1098
10. Pizer ES, Chrest FJ, DiGiuseppe JA, Han WF. Pharmacological inhibitor of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res, 1998; 58: 4611-4615