Fatty acid synthase expression in Japanese breast carcinoma patients

International Journal of Molecular Medicine

Volumn 4, Issue 4, 1999, Pages 381-387

  Nakamura, Izumi ^a   Kimijima, Izo ^a   Zhang, Guo Jun ^a   Onogi, Hitoshi ^a   Endo, Yoshiyuki ^a   Suzuki, Shinich ^a   Tuchiya, Atuo ^a   Takenoshita, Seiichi ^a   Kusakabe, Takashi ^a   Suzuki, Toshimitsu ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Bbreast carcinoma; Estrogen receptor; Fatty acid synthase; Immunohistochemical method; Nodal status; Progesterone receptor

Indexed keywords

ESTROGEN RECEPTOR; FATTY ACID SYNTHASE; FORMALDEHYDE; PARAFFIN; PROGESTERONE RECEPTOR; STEROID RECEPTOR; TUMOR MARKER;

ADJUVANT CHEMOTHERAPY; ADULT; ARTICLE; BREAST CARCINOMA; CANCER PATIENT; CANCER SURGERY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; JAPANESE (PEOPLE); LYMPH NODE DISSECTION; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PREMENOPAUSE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; SEGMENTAL MASTECTOMY; STAINING; TISSUE SECTION; TUMOR VOLUME; AGE; AGED; BIOSYNTHESIS; BREAST TUMOR; ENZYMOLOGY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; POSTMENOPAUSE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; POSTMENOPAUSE; PREMENOPAUSE; TUMOR MARKERS, BIOLOGICAL;

EID: 0033210886     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.4.4.381     Document Type: Article

References (20)

1. Roncari DA: Mammalian fatty acid synthetase. I. Purification and properties of human liver complex. Can J Biochem 52: 221-230, 1974.
2. Goldrick RB and Galton DJ: Fatty acid synthesis de novo in human adipose tissue. Clin Sei Mol Med 46: 469-479, 1974.
3. Escot C, Joyeux C and Mathieu M: Regulation of fatty acid synthetase ribonucleic acid in the human endometrium during the menstrual cycle. J Clin Endocrinol Metab 70: 1319-1324, 1990.
4. Ballard PL, Liley HG and Gonzales LW: Interferon-gamma and synthesis of surfactant components by cultured human fetal lung. Am J Respir Cell Mol Biol 2: 137-143, 1990.
5. Joyeux C, Chalbos D and Rochefort H: Effects of progestins and menstrual cycle on fatty acid synthetase and PgR in human mammary glands. J Clin Endocrinol Metab 70: 1438-1444, 1990.
6. Joyeux C, Rochefort H and Chalbos D: Progestin increases gene transcription and messenger ribonucleic acid stability of fatty acid synthetase in breast cancer cells. Mol Endocrinol 3: 681-686, 1989.
7. Chalbos D, Chambon M, Ailhaud G and Rochefort H: Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells. J Biol Chem 262: 9923-9926, 1987.
8. Chalbos D, Escot C, Joyeux C, Tissot-Carayon MJ, Pages A and Rochefort H: Expression of the progestin-induced fatty acid synthetase in benign mastopathies and breast cancer as measured by RNA in situ hybridization. J Natl Cancer Inst 82: 602-606, 1990.
9. Chalbos D, Joyeux C, Escot C, Galtier F and Rochefort H: Progestin-induced fatty acid synthetase in breast cancer. From molecular biology to clinical applications. Ann NY Acad Sei 595: 67-73, 1990.
10. Milgraum LZ, Witters LA, Pasternack GR and Kuhajda FP: Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 3: 2115-2120, 1997.
11. Pizer ES, Lax SF, Kuhajda FP, Pasternack GR and Kurman RJ: Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. Cancer 83: 528-537, 1998.
12. Esquenet M, Swinnen JV, van Veldhoven PP, Denef C, Heyns W and Verhoeven G: Retinoids stimulate lipid synthesis and accumulation in LNCaP prostatic adenocarcinoma cells. Mol Cell Endocrinol 136: 37-46, 1997.
13. Swinnen JV and Verhoeven G: Androgens and the control of lipid metabolism in human prostate cancer cells. J Steroid Biochem Mol 65: 191-198, 1998.
14. Shurbaji MS, Kalbfleisch JH and Thurmond TS: Immunohistochemical detection of fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol 27: 917-921, 1996.
15. Rashid A, Pizer ES, Moga M, Milgaum LZ, Zahurak M and Pasternack R: Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 150: 201-208, 1997.
16. Alo PL, Visca P, Marci A, Mangoni A, Botti C and Di Tondo U: Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 77: 474-482, 1996.
17. Hahnel E, Harvey J, Robbins P, Sterrett G and Hahnel R: Hormone-regulated genes (pS2, PIP, FAS) in breast cancer and non-tumoral mammary tissue. Pathobiology 62: 82-89, 1994.
18. Wysocki SJ, Hahnel E, Wilkinson SP, Smith V and Hahnel R: Hormone-sensitive gene expression in breast tumours. Anticancer Res 10: 185-188, 1995.
19. Wei LL, Krett NL and Francis MD: Multiple human PgR messenger ribonucleic acids and their autoregulation by progestin agoists and antagonists in breast cancer cells. Mol Endocrinol 2: 62-72, 1988.
20. Jansen V, Ladekal M, Holm-Nielsen P, Melsen F and Soerensen FB: The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer. J Pathol 176: 343-352, 1995.