Nothing Iffy about HIF in the hypothalamus

PLoS Biology

Volumn 9, Issue 7, 2011, Pages

  Virtue, Sam ^a   Vidal Puig, Antonio ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; HYPOXIA INDUCIBLE FACTOR; PROOPIOMELANOCORTIN; PROTEIN IFFY; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; GLUCOSE; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ARTICLE; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; HOMEOSTASIS; HYPOTHALAMUS; METABOLISM; NONHUMAN; NUTRIENT; OXYGEN SENSING; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; ENERGY METABOLISM; FEMALE; GENETICS; MALE; NOTE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ENERGY METABOLISM; FEMALE; GLUCOSE; HYPOTHALAMUS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; PRO-OPIOMELANOCORTIN;

EID: 79960903344     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001116     Document Type: Article

References (22)

1. Koivunen P, Hirsila M, Kivirikko K. I, Myllyharju J, (2006) The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem 281: 28712-28720.
2. Koivunen P, Hirsila M, Gunzler V, Kivirikko K. I, Myllyharju J, (2004) Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279: 9899-9904.
3. Ehrismann D, Flashman E, Genn D. N, Mathioudakis N, Hewitson K. S, et al. (2007) Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J 401: 227-234.
4. Aragones J, Fraisl P, Baes M, Carmeliet P, (2009) Oxygen sensors at the crossroad of metabolism. Cell Metab 9: 11-22.
5. Majmundar A. J, Wong W. J, Simon M. C, (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40: 294-309.
6. Kaelin W. G Jr, Ratcliffe P. J, (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402.
7. Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, et al. (2001) Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414: 550-554.
8. Lando D, Peet D. J, Gorman J. J, Whelan D. A, Whitelaw M. L, et al. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471.
9. Mahon P. C, Hirota K, Semenza G. L, (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686.
10. Iyer N. V, Kotch L. E, Agani F, Leung S. W, Laughner E, et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-162.
11. Rankin E. B, Rha J, Selak M. A, Unger T. L, Keith B, et al. (2009) Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol 29: 4527-4538.
12. Kaelin W. G Jr, (2008) The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873.
13. Bernhardt W. M, Wiesener M. S, Scigalla P, Chou J, Schmieder R. E, et al. (2010) Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 21: 2151-2156.
14. Kasiganesan H, Sridharan V, Wright G, (2007) Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance. Acta Physiol (Oxf) 190: 163-169.
15. Trayhurn P, Wang B, Wood I. S, (2008) Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100: 227-235.
16. Zhang N, Fu Z, Linke S, Chicher J, Gorman J. J, et al. (2010) The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 11: 364-378.
17. Zhang H, Zhang G, Gonzalez F. J, Park S, Cai D, (2011) Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol 9: e1001112 doi:10.1371/journal.pbio.1001112.
18. Demidenko Z. N, Blagosklonny M. V, (2011) The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1alpha. Cell Cycle 10: 1557-1562.
19. Bento C. F, Pereira P, (2011) Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes. Diabetologia In press.
20. Isoe T, Makino Y, Mizumoto K, Sakagami H, Fujita Y, et al. (2010) High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein. Kidney Int 78: 48-59.
21. Lopez M, Lage R, Saha A. K, Perez-Tilve D, Vazquez M. J, et al. (2008) Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 7: 389-399.
22. Cota D, Proulx K, Smith K. A, zma S. C, Thomas G, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930.