Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: Vitamin C as a probe for imaging redox status in vivo

Journal of the American Chemical Society

Volumn 133, Issue 30, 2011, Pages 11795-11801

  Bohndiek, Sarah E ^a   Kettunen, Mikko I ^a   Hu, De En ^a   Kennedy, Brett W C ^a   Boren, Joan ^a   Gallagher, Ferdia A ^a   Brindle, Kevin M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACIDS; CELL SUSPENSION; DEHYDROASCORBIC ACID; DYNAMIC NUCLEAR POLARIZATION; EXTRACELLULAR; GLUTATHIONES; HYPERPOLARIZATION; HYPERPOLARIZED; IN-VITRO; IN-VIVO; INTRACELLULAR REDUCTION; INTRAVENOUS ADMINISTRATION; LYMPHOMA CELLS; METABOLIC PRODUCTS; MICROENVIRONMENTS; REDOX STATE; REDOX STATUS; SPONTANEOUS REACTIONS; VITAMIN C;

CELL CULTURE; ENZYME ACTIVITY; KETONES; METABOLISM; ONCOLOGY; ORGANIC ACIDS; OXIDATION; POLARIZATION; PROBES; SUBSTRATES; TUMORS;

VITAMINS;

ASCORBIC ACID; ASCORBIC ACID C 13; BIOLOGICAL MARKER; CARBON 13; DEHYDROASCORBIC ACID; DEHYDROASCORBIC ACID C 13; GLUTATHIONE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ANIMAL CELL; ARTICLE; CANCER LOCALIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; HYPERPOLARIZATION; LYMPHOMA; LYMPHOMA CELL LINE; MOLECULAR IMAGING; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; REACTION ANALYSIS; REACTION TIME; CHEMICAL STRUCTURE; CHEMISTRY; OXIDATION REDUCTION REACTION; STEREOISOMERISM;

ASCORBIC ACID; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STEREOISOMERISM;

EID: 79960886776     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2045925     Document Type: Article

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