Hyperpolarized [2-13C]-fructose: A hemiketal DNP substrate for in vivo metabolic imaging

Journal of the American Chemical Society

Volumn 131, Issue 48, 2009, Pages 17591-17596

  Keshari, Kayvan R ^a,b   Wilson, David M ^a   Chen, Albert P ^c   Bok, Robert ^a   Larson, Peder E Z ^a   Hu, Simon ^a   Van Criekinge, Mark ^a   Macdonald, Jeffrey M ^b   Vigneron, Daniel B ^a   Kurhanewicz, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c GE HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EX-VIVO; FATTY LIVER DISEASE; HEXOKINASES; HYPERPOLARIZATION; HYPERPOLARIZED; IN-VIVO; METABOLIC IMAGING; METABOLIC PATHWAYS; MOLECULAR PROBES; PROSTATE CANCERS; SIGNAL DECAY; SIGNAL ENHANCEMENT; SPECTROSCOPIC IMAGING; TRANSGENIC MODELS;

BIOCHEMISTRY; CARBOHYDRATES; CARBOXYLATION; FRUCTOSE; GLUCOSE; METABOLISM; PATHOLOGY; PLANTS (BOTANY); PROBES;

SPIN POLARIZATION;

2 FRUCTOSE C 13; CARBON; CARBOXYLIC ACID DERIVATIVE; GLUCOSE; HEXOKINASE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; FRUCTOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG UPTAKE; EX VIVO STUDY; GLYCOLYSIS; HYPERPOLARIZATION; IN VIVO STUDY; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; PROSTATE CANCER; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; MALE; METABOLISM; METHODOLOGY; PROSTATE TUMOR; SPECTROSCOPY;

ANIMALS; CARBON ISOTOPES; FRUCTOSE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MOLECULAR IMAGING; PROSTATIC NEOPLASMS; SPECTRUM ANALYSIS;

EID: 72249086965     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9049355     Document Type: Article

References (40)

1. Ardenkjaer-Larsen, J. H.; Fridlund, B.; Gram, A.; Hansson, G.; Hansson, L.; Lerche, M. H.; Servin, R.; Thaning, M.; Golman, K. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 10158-10163.
2. Golman, K.; Zandt, R. I.; Lerche, M. H.; Pehrson, R.; Ardenkjaer-Larsen, J. H. Cancer Res. 2006, 66, 10855-10860.
3. Albers, M. J.; Bok, R.; Chen, A. P.; Cunningham, C. H.; Zierhut, M. L.; Zhang, V. Y.; Kohler, S. J.; Tropp, J.; Hurd, R. E.; Yen, Y. F.; Nelson, S. J.; Vigneron, D. B.; Kurhanewicz, J. Cancer Res. 2008, 68, 8607-8615.
4. Day, S. E.; Kettunen, M. I.; Gallagher, F. A.; Hu, D. E.; Lerche, M.; Wolber, J.; Golman, K.; Ardenkjaer-Larsen, J. H.; Brindle, K. M. Nat. Med. 2007, 13, 1382-1387.
5. Abragam, A.; Goldman, M. Rep. Prog. Phys. 1978, 41, 395-463.
6. Borghini, M. Phys. Rev. Lett. 1968, 20, 419-421.
7. Chen, A. P.; Kurhanewicz, J.; Bok, R.; Xu, D.; Joun, D.; Zhang, V.; Nelson, S. J.; Hurd, R. E.; Vigneron, D. B. Magn. Reson. Imaging 2008, 26, 721-726.
8. Merritt, M. E.; Harrison, C.; Storey, C.; Jeffrey, F. M.; Sherry, A. D.; Malloy, C. R. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 19773-19777.
9. Wilson, D. M.; Hurd, R. E.; Keshari, K. R.; Van Criekinge, M.; Chen, A. P.; Nelson, S. J.; Vigneron, D. B.; Kurhanewicz, J. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 5503-5507.
10. Schroeder, M. A.; Atherton, H. J.; Ball, D. R.; Cole, M. A.; Heather, L. C.; Griffin, J. L.; Clarke, K.; Radda, G. K.; Tyler, D. J. FASEB J. 2009, 23, 2529-2538.
11. Warren, W. S.; Jenista, E.; Branca, R. T.; Chen, X. Science 2009, 323, 1711-1714.
12. Denko, N. C. Nat. Rev. Cancer 2008, 8, 705-713.
13. Ganapathy, V.; Thangaraju, M.; Prasad, P. D. Pharmacol. Ther. 2008, 121, 29-40.
14. Kroemer, G.; Pouyssegur, J. Cancer Cell 2008, 13, 472-482.
15. Farrell, G.; Larter, C. Hepatology 2006, 43, S99-S112.
16. Huynh, M.; Luiken, J. J.; Coumans, W.; Bell, R. Obesity (Silver Spring) 2008, 16, 1755-1762.
17. Douard, V.; Ferraris, R. P. Am. J. Physiol. Endocrinol. Metab. 2008, 295, E227-237.
18. Antoniewicz, M. R.; Kelleher, J. K.; Stephanopoulos, G. Metab. Eng. 2006, 8, 324-337.
19. Lane, A. N.; Fan, T. W.; Higashi, R. M.; Tan, J.; Bousamra, M.; Miller, D. M. Exp. Mol. Pathol. 2009, 86, 165-173.
20. Bais, R.; James, H. M.; Rofe, A. M.; Conyers, R. A. Biochem. J. 1985, 230, 53-60.
21. Skoog, M.; Johansson, G.; Olsson, B.; Appelqvist, R. Mikrochim. Acta 1988, III, 131-142.
22. Funari, V.; Herrera, V.; Freeman, D.; Tolan, D. Mol. Brain Res. 2005, 142, 115-122.
23. Petersen, A.; Kappler, F.; Szwergold, B. S.; Brown, T. R. Biochem. J. 1992, 284 (Pt 2), 363-366.
24. Levi, J.; Cheng, Z.; Gheysens, O.; Patel, M.; Chan, C. T.; Wang, Y.; Namavari, M.; Gambhir, S. S. Bioconjugate Chem. 2007, 18, 628-634.
25. Voet, D.; Voet, J. G. Biochemistry; 3rd ed.; John Wiley & Sons: New York, 2004.
26. Tong, X.; Zhao, F.; Thompson, C. B. Curr. Opin. Genet. Dev. 2009, 19, 32-37.
27. Vizán, P.; Alcarraz-Vizán, G.; Díaz-Moralli, S.; Solovjeva, O.; Frederiks, W.; Cascante, M. Int. J. Cancer 2009, 124, 2789-2796.
28. Zamora-León, S. P.; Golde, D. W.; Concha, I. I.; Rivas, C. I.; Delgado-López, F.; Baselga, J.; Nualart, F.; Vera, J. C. Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 1847-1852.
29. Sreekumar, A.; et al. Nature 2009, 457, 910-914.
30. Gallagher, F. A.; Kettunen, M. I.; Day, S. E.; Lerche, M.; Brindle, K. M. Magn. Reson. Med. 2008, 60, 253-257.
31. Golman, K.; Ardenkjaer-Larsen, J. H.; Petersson, J. S.; Mansson, S.; Leunbach, I. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 10435-10439.
32. Hu, S.; Lustig, M.; Chen, A. P.; Crane, J.; Kerr, A.; Kelley, D. A.; Hurd, R.; Kurhanewicz, J.; Nelson, S. J.; Pauly, J. M.; Vigneron, D. B. J. Magn. Reson. 2008, 192, 258-264.
33. Wang, Y. M.; van Eys, J. Annu. Rev. Nutr. 1981, 1, 437-475.
34. Goux, W. J. J. Am. Chem. Soc. 1985, 107, 4320-4327.
35. Gallagher, F. A.; Kettunen, M. I.; Day, S. E.; Hu, D. E.; Ardenkjaer-Larsen, J. H.; in't Zandt, R.; Jensen, P. R.; Karlsson, M.; Golman, K.; Lerche, M. H.; Brindle, K. M. Nature 2008, 453, 940-U973.
36. Ven, F. J. M. v. d. Multidimensional NMR in Liquids: Basic Principles and Experimental Methods; Wiley-VCH: New York, 1995; pp 356-358.
37. Merritt, M. E.; Harrison, C.; Storey, C.; Sherry, A. D.; Malloy, C. R. Magn. Reson. Med. 2008, 60, 1029-1036.
38. Kohler, S. J.; Yen, Y.; Wolber, J.; Chen, A. P.; Albers, M. J.; Bok, R.; Zhang, V.; Tropp, J.; Nelson, S. J.; Vigneron, D. B.; Kurhanewicz, J.; Hurd, R. E. Magn. Reson. Med. 2007, 58, 65-69.
39. Schroeder, M. A.; Cochlin, L. E.; Heather, L. C.; Clarke, K.; Radda, G. K.; Tyler, D. J.; Shulman, R. G. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 12051-12056.
40. Donnelly, K. L.; Smith, C. I.; Schwarzenberg, S. J.; Jessurun, J.; Boldt, M. D.; Parks, E. J. J. Clin. Invest. 2005, 115, 1343-1351.