The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vitro and in vivo

Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

Volumn 46, Issue 5, 2011, Pages 526-533

  Bokulić, Ana ^a,c   Garaj Vrhovac, Verica ^b   Brajša, Karmen ^a   Durić, Koraljka ^a   Glojnarić, Ines ^a   Šitum, Kristina ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^c Galapagos istraživački centar doo ^*  (Croatia)

Author keywords

Ames test; Antitumor drugs; Apigenin; Cyclophosphamide; Doxorubicin; Flavonoids; Micronucleus test

Indexed keywords

AMES TEST; ANTITUMOR DRUGS; APIGENIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; MICRONUCLEUS TEST;

ANIMALS; BLOOD; FLAVONOIDS; FREQUENCY RESPONSE; METABOLISM; OXYGEN;

DRUG DOSAGE;

APIGENIN; CD1 ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLAVONOID; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SMEAR; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROSCOPY; MOUSE; MUTAGENICITY; NONHUMAN; PLASMA; RAT; REVERTANT; ANIMAL; BLOOD; CHEMISTRY; DNA DAMAGE; MUTAGEN TESTING; SALMONELLA TYPHIMURIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APIGENIN; CYCLOPHOSPHAMIDE; DNA DAMAGE; DOXORUBICIN; GLUTATHIONE PEROXIDASE; MICE; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM; SUPEROXIDE DISMUTASE;

EID: 79960861556     PISSN: 10934529     EISSN: 15324117     Source Type: Journal    
DOI: 10.1080/10934529.2011.551744     Document Type: Article

References (45)

1. Blaszkowsky, L.S.; Erlichman, C. Carcinogenesis of anticancer drugs. In Cancer chemotherapy and biotherapy: Principles and practice; Chabner, B.A., Longo, D.L., Eds.; Lippincott Williams & Wilkins: Philadelphia, 2006; 70-90.
2. Keizer, H.G.; Pinedo, H.M.; Schuurhuis, G.J.; Joenje, H. Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol. Ther. 1990, 47 (2), 219-231. (Pubitemid 20228581)
3. Smith, J.J.; Tully, P.; Padberg, R.M. Chemoprevention: A primary cancer prevention strategy. Seminars in Oncology Nursing 2005, 21 (4), 243-251. (Pubitemid 41627507)
4. Aydemir, N.; Çelikler, S.; Bilaloñlu, R. In vitro genotoxic effects of the anticancer drug gemcitabine in human lymphocytes.Muta. Res. Genetic Toxicol. Environ. Mutagen. 2005, 582 (1-2), 35-41. (Pubitemid 40386919)
5. Nafisi, S.; Hashemi, M.; Rajabi, M.; Tajmir-Riahi, H.A. DNA adducts with antioxidant flavonoids:Morin, apigenin, and naringin. DNA Cell Biol. 2008, 27 (8), 433-442.
6. Uhl, M.; Ecker, S.; Kassie, F.; Lhoste, E.; Chakraborty, A.; Mohn, G.; Knasmuller, S. Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4, 5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (Hep G2) cells. Arch. Toxicol. 2003, 77 (8), 477-484. (Pubitemid 37100613)
7. Wang, I.-K.; Lin-Shiau, S.-Y.; Lin, J.-K. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur. J. Cancer 1999, 35 (10), 1517-1525. (Pubitemid 29454650)
8. Ujiki, M.B.; Ding, X.-Z.; Salabat, M.R.; Bentrem, D.J.; Golkar, L.; Milam, B.; Talamonti, M.S.; Bell Jr., R.H.; Iwamura, T.; Adrian, T.E. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol. Cancer 2006, 5, 76.
9. Hertog, M.G.L.; Hollman, P.C.H.; Katan, M.B.; Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr. Cancer 1993, 20 (1), 21-29. (Pubitemid 23225364)
10. Pietta, P.; Gardana, C.; Pietta, A. Flavonoids in herbs. In Flavonoids in health and disease; Rice-Evans, C.A., Packer, L., Eds.; Marcel Dekker: New York, 2003, 43-70.
11. Soobrattee, M.A.; Neergheen, V.S.; Luximon-Ramma, A.; Aruoma, O.I.; Bahorun, T. Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mut. Res. 2005, 579 (1-2), 200-213. (Pubitemid 41540144)
12. Siddique, Y.H.; Afzal, M. Protective effect of apigenin against hydrogen peroxide induced genotoxic damage on cultured human peripheral blood. J. Appl. Biomed. 2009, 7 (1), 35-43.
13. Rithidech, K.N.; Tungjai, M.; Whorton, E.B. Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes. Mut. Res. 2005, 585 (1-2), 96-104. (Pubitemid 40980423)
14. Jeyabal, P.V.S.; Syed, M.B.; Venkataraman, M.; Sambandham, J.K.; Sakthisekaran, D.Apigenin inhibits oxidative stress-induced macromolecular damage inN-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. Molec. Carcin. 2005, 44 (1), 11-20. (Pubitemid 41216403)
15. Khan, T.H.; Jahangir, T.; Prasad, L.; Sarwat, S. Inhibitory effect of apigenin on benzo(a) pyrene-mediated genotoxicity in Swiss albino mice. J. Pharm. Pharmacol. 2006, 58 (12), 1655-1660. (Pubitemid 46051682)
16. Gajski, G.; Garaj Vrhovac V. Increased frequency of sister chromatid exchanges and decrease in cell viability and proliferation kinetics in human peripheral blood lymphocytes after in vitro exposure to whole bee venom. J. Environ. Sci. Health A 2010, 45 (12), 1654-1659.
17. Birt, D.F.; Walker, B.; Tibbels, M.G.; Bresnick, E. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis 1986, 7 (6), 959-963.
18. Choi, J.S.; Park, K.Y.; Moon, S.H.; Rhee, S.H.; Young, H.S. Antimutagenic effect of plant flavonoids in the Salmonella assay system. Arch. Pharm. Res. 1994, 17 (2), 71-75.
19. Nagasugi, T.; Nakashima, M.; Komai, K. Antimutagens in gaiyou (Artemisia argyi levl. et vant.). J. Agric. Food Chem. 2000, 48 (8), 3256-3266.
20. Balasubramanian, S.; Eckert, R.L. Keratinocyte proliferation, differentiation, and apoptosis-Differential mechanisms of regulation by curcumin, EGCGand apigenin. Toxicol.Appl. Pharmacol. 2007, 224 (3), 214-219. (Pubitemid 47575681)
21. Torkin, R.; Lavoie, J.-F.; Kaplan, D.R.; Yeger, H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Molec. Cancer Ther. 2005, 4 (1), 1-11. (Pubitemid 40268061)
22. Maron, D.M.; Ames, B.N. Revised methods for the Salmonella mutagenicity test. Mut. Res. 1983, 113 (3-4), 173-215. (Pubitemid 13120319)
23. Musatov, S.A.; Anisimov, V.N.; André, V.; Vigreux, C.; Godard, T.; Gauduchon, P.; Sichel, F. Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and comet assay. Mut. Res. 1998, 417 (2-3) , 75-84. (Pubitemid 28414379)
24. Morita, T.; Asano, N.; Awogi, T.; Sasaki, Y.F.; Sato, S.-I.; Shimada, H.; Sutou, S.; Suzuki, T.; Wakata, A.; Sofuni, T.; Hayashi, M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B): The summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group. Mut. Res. 1997, 389 (1), 3-122. (Pubitemid 27314256)
25. Hayashi, M.; Morita, T.; Kodama, Y.; Sofuni, T.; Ishidate Jr., M. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mut. Res. 1990, 245 (4), 245-249.
26. Noel, S.; Kasinathan, M.; Rath, S.K. Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay. Toxicol. in Vitro 2006, 20 (7), 1168-1172. (Pubitemid 44067381)
27. Garaj Vrhovac, V.; Ore?sLanin, V.; Ruk, D.; Gajski, G. In vitro assessment of genotoxic effects of electric arc furnace dust on human lymphocytes using the alkaline comet assay. J. Environ. Sci. Health A.. 2009, 44 (3), 279-87.
28. Nijveldt, R.J.; Van Nood, E.; Van Hoorn, D.E.C.; Boelens, P.G.; Van Norren, K.; Van Leeuwen, P.A.M. Flavonoids: A review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 2001, 74 (4), 418-425. (Pubitemid 32880250)
29. Nagao, M.; Morita, N.; Yahagi, T.; Shimizu, M.; Kuroyanagi, M.; Fukuoka, M.; Yoshihira, K.; Matori, S.; Fujino, T.; Sugimura, T. Mutagenicities of 61 flavonoids and 11 related compounds. Environ. Mut. 1981, 3 (4), 401-420.
30. Czeczot, H.; Tudek, B.; Kusztelak, J.; Szymczyk, T.; Dobrowolska, B.; Glinkowska, G.; Malinowski, J.; Strzelecka, H. Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs. Mut. Res. 1990, 240 (3), 209-216. (Pubitemid 20075452)
31. Cutts, S.M.; Nudelman, A.; Rephaeli, A.; Phillips, D.R. The power and potential of doxorubicin-DNA adducts. IUBMB Life 2005, 57 (2), 73-81. (Pubitemid 40632297)
32. Webb, M.R.; Ebeler, S.E. Comparative analysis of topoisomerase IB inhibition andDNAintercalation by flavonoids and similar compounds: Structural determinates of activity. Biochem. J. 2004, 384 (Pt 3), 527-541. (Pubitemid 40018966)
33. Kanakis, C.D.; Nafisi, S.; Rajabi, M. Structural analysis of DNA and RNA interactions with antioxidant flavonoids. Spectroscopy 2009, 23 (1), 29-43.
34. Snyder, R.D.; Gillies, P.J. Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. Environ. Molec. Mut, 2002, 40 (4), 266-276. (Pubitemid 36068845)
35. Wan, L.; Guo, C.; Yu, Q.; Li, Y.; Wang, X. Wang, X.; Chen, C. Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry. J. Chromatogr. B. 2007, 855 (2), 286-289. (Pubitemid 47212016)
36. Samy, R.P.; Gopalakrishnakone, P.; Ignacimuthu, S. Antitumor promoting potential of luteolin against 7, 12- dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem. Biol. Interact. 2006, 164 (1-2), 1-14. (Pubitemid 44709707)
37. Fleming, R.A. An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy.1997, 17 (5 Pt 2), 146S-154S. (Pubitemid 27411255)
38. Sharma, N.; Trikha, P.; Athar, M.; Raisuddin, S. Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia. Mut. Res. 2001, 480-481, 179-88. (Pubitemid 32744826)
39. Chen, Y.; Jia, X.; Chen, J.; Wang, J.; Hu, M. The pharmacokinetics of raloxifene and its interaction with apigenin in rat. Molecules.2010, 15 (11), 8478-8487.
40. Psotová, J.; Chlopčíkova, ? S.; Miketová, P.; Hrbác, J.; ?Simánek, V. Chemoprotective effect of plant phenolics against anthracyclineinduced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin.Phytother.Res. 2004, 18 (7), 516-521. (Pubitemid 39079145)
41. Navarro, J.; Obrador, E.; Carretero, J.; Petschen, I.; Avinó, J.; Perez, P.; Estrela, J.M. Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo. Free Rad. Biol. Med. 1999, 26 (3-4), 410-418.
42. Thomasset, S.C.; Berry, D.P.; Garcea, G.; Marczylo, T.; Steward, W.P.; Gescher, A.J. Dietary polyphenolic phytochemicals - Promising cancer chemopreventive agents in humans? A review of their clinical properties. Int. J. Cancer 2007, 120 (3), 451-458. (Pubitemid 44969013)
43. Subapriya, R.; Kumaraguruparan, R.; Abraham, S.K.; Nagini, S. Protective effects of ethanolic neem leaf extract on N-methyl-N- nitro-N-nitrosoguanidine- induced genotoxicity and oxidative stress in mice. Drug Chem. Toxicol. 2004, 27 (1), 15-26. (Pubitemid 38304856)
44. Kumaraguruparan, R.; Chandra Mohan, K.V.P.; Abraham, S.K.; Nagini, S. Attenuation of N-methyl-N-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination. Life Sci. 2005, 76 (19), 2247-2255. (Pubitemid 40283649)
45. Larramendy, M.L.; Bianchi, M.S.; Padron, J. Correlation between the anti-oxidant enzyme activities of blood fractions and the yield bleomycin-induced chromosome damage. Mut. Res. 1989, 214 (1), 129-136. (Pubitemid 19220295)