메뉴 건너뛰기




Volumn 27, Issue 1, 2004, Pages 15-26

Protective Effects of Ethanolic Neem Leaf Extract on N-Methyl-N′ -nitro-N-nitrosoguanidine-Induced Genotoxicity and Oxidative Stress in Mice

Author keywords

Antioxidants; Glutathione; Micronuclei; MNNG; Neem; Oxidative stress

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDE; METHYLNITRONITROSOGUANIDINE; PLANT EXTRACT;

EID: 1542379843     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120027894     Document Type: Article
Times cited : (53)

References (45)
  • 2
    • 0027032112 scopus 로고
    • Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiology
    • Bartsch, H.; Ohshima, H.; Pignatelli, B.; Calmels, S. Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiology. Pharmacogenetics 1992, 2, 272-277.
    • (1992) Pharmacogenetics , vol.2 , pp. 272-277
    • Bartsch, H.1    Ohshima, H.2    Pignatelli, B.3    Calmels, S.4
  • 3
    • 0034942002 scopus 로고    scopus 로고
    • Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats
    • Okino, T.; Onda, M.; Matsukura, N.; Inada, K.I.; Tatematsu, M.; Suzuki, S.; Shimada, T. Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats. Jpn. J. Cancer Res. 2001, 92, 673-679.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 673-679
    • Okino, T.1    Onda, M.2    Matsukura, N.3    Inada, K.I.4    Tatematsu, M.5    Suzuki, S.6    Shimada, T.7
  • 4
    • 0032776093 scopus 로고    scopus 로고
    • Chemopreventive potential of garlic and neem during gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine
    • Arivazhagan, S.; Balasenthil, S.; Nagini, S. Chemopreventive potential of garlic and neem during gastric carcinogenesis induced by N-methyl-N′ -nitro-N-nitrosoguanidine. Med. Sci. Res. 1999, 27, 209-212.
    • (1999) Med. Sci. Res. , vol.27 , pp. 209-212
    • Arivazhagan, S.1    Balasenthil, S.2    Nagini, S.3
  • 5
    • 0035688335 scopus 로고    scopus 로고
    • Attenuation by garlic and neem leaf extracts of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine
    • Arivazhagan, S.; Balasenthil, S.; Nagini, S. Attenuation by garlic and neem leaf extracts of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine. GI Cancer 2001, 3, 375-382.
    • (2001) GI Cancer , vol.3 , pp. 375-382
    • Arivazhagan, S.1    Balasenthil, S.2    Nagini, S.3
  • 6
    • 0036122761 scopus 로고    scopus 로고
    • Prevention of N-methyl-N′-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene
    • Velmurugan, B.; Bhuvaneswari, V.; Usha, K.B.; Nagini, S. Prevention of N-methyl-N′-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. Eur. J. Cancer Prev. 2002, 11, 19-26.
    • (2002) Eur. J. Cancer Prev. , vol.11 , pp. 19-26
    • Velmurugan, B.1    Bhuvaneswari, V.2    Usha, K.B.3    Nagini, S.4
  • 8
    • 0035451067 scopus 로고    scopus 로고
    • Antimutagenesis and anticarcinogenesis, from the past to the future
    • Weisburger, J.H. Antimutagenesis and anticarcinogenesis, from the past to the future. Mutat. Res. 2001, 480-481, 23-35.
    • (2001) Mutat. Res. , vol.480-481 , pp. 23-35
    • Weisburger, J.H.1
  • 9
    • 0023756891 scopus 로고
    • Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis
    • Ketterer, B. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat. Res. 1988, 202, 336-343.
    • (1988) Mutat. Res. , vol.202 , pp. 336-343
    • Ketterer, B.1
  • 10
    • 0002925047 scopus 로고    scopus 로고
    • Biological activities and medicinal properties of neem (Azadirachta indica)
    • Biswas, K.; Chattopadhyay, I.; Banerjee, R.K.; Bandyopadhyay, U. Biological activities and medicinal properties of neem (Azadirachta indica). Current Sci. 2002, 82, 1336-1345.
    • (2002) Current Sci. , vol.82 , pp. 1336-1345
    • Biswas, K.1    Chattopadhyay, I.2    Banerjee, R.K.3    Bandyopadhyay, U.4
  • 11
    • 0031397659 scopus 로고    scopus 로고
    • Biomonitoring the chemopreventive potential of the plant products neem and turmeric in 4-nitroquinoline 1-oxide induced oral carcinogenesis
    • Nagini, S.; Manoharan, S. Biomonitoring the chemopreventive potential of the plant products neem and turmeric in 4-nitroquinoline 1-oxide induced oral carcinogenesis. J. Clin. Biochem. Nutr. 1997, 23, 33-40.
    • (1997) J. Clin. Biochem. Nutr. , vol.23 , pp. 33-40
    • Nagini, S.1    Manoharan, S.2
  • 12
    • 0032851388 scopus 로고    scopus 로고
    • Chemopreventive potential of neem on 7,12-dimethylbenz(a) anthracene induced hamster buccal pouch carcinogenesis
    • Balasenthil, S.; Arivazhagan, S.; Ramachandran, C.R.; Ramachandran, V.; Nagini, S. Chemopreventive potential of neem on 7,12-dimethylbenz(a) anthracene induced hamster buccal pouch carcinogenesis. J. Ethnopharmacol. 1999, 67, 189-195.
    • (1999) J. Ethnopharmacol. , vol.67 , pp. 189-195
    • Balasenthil, S.1    Arivazhagan, S.2    Ramachandran, C.R.3    Ramachandran, V.4    Nagini, S.5
  • 13
    • 0034048872 scopus 로고    scopus 로고
    • Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine induced gastric carcinogenesis in rats
    • Arivazhagan, S.; Balasenthil, S.; Nagini, S. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine induced gastric carcinogenesis in rats. Phytother. Res. 2000, 14, 291-293.
    • (2000) Phytother. Res. , vol.14 , pp. 291-293
    • Arivazhagan, S.1    Balasenthil, S.2    Nagini, S.3
  • 14
    • 0027443096 scopus 로고
    • Possible mechanism of antihyperglycaemic effect of Azadirachta indica leaf extract. Part I
    • Chattopadhyay, R.N.; Maitra, S.K.; Chattopadhyay, R.R. Possible mechanism of antihyperglycaemic effect of Azadirachta indica leaf extract. Part I. Fitoterapia 1993, 64, 332-335.
    • (1993) Fitoterapia , vol.64 , pp. 332-335
    • Chattopadhyay, R.N.1    Maitra, S.K.2    Chattopadhyay, R.R.3
  • 15
    • 0031875056 scopus 로고    scopus 로고
    • Possible biochemical mode of anti-inflammatory action of Azadirachta indica A. Juss. in rats
    • Chattopadhyay, R.R. Possible biochemical mode of anti-inflammatory action of Azadirachta indica A. Juss. in rats. Indian J. Exp. Biol. 1998, 36, 418-420.
    • (1998) Indian J. Exp. Biol. , vol.36 , pp. 418-420
    • Chattopadhyay, R.R.1
  • 16
    • 0030903379 scopus 로고    scopus 로고
    • Antifertility effects of aqueous and steroidal extracts of neem leaf (Azadirachta indica) in male Wistar rats
    • Parshad, O.; Gardner, M.T.; The, T.L.; Williams, L.A.D.; Fletcher, C.K. Antifertility effects of aqueous and steroidal extracts of neem leaf (Azadirachta indica) in male Wistar rats. Phytother. Res. 1997, 11, 168-170.
    • (1997) Phytother. Res. , vol.11 , pp. 168-170
    • Parshad, O.1    Gardner, M.T.2    The, T.L.3    Williams, L.A.D.4    Fletcher, C.K.5
  • 17
    • 0027256348 scopus 로고
    • The gastric antiulcer effects of the leaves of the neem tree
    • Garg, G.P.; Nigam, S.K.; Ogle, C.W. The gastric antiulcer effects of the leaves of the neem tree. Planta. Med. 1992, 59, 215-217.
    • (1992) Planta. Med. , vol.59 , pp. 215-217
    • Garg, G.P.1    Nigam, S.K.2    Ogle, C.W.3
  • 18
    • 0024846535 scopus 로고
    • Inhibition of in vivo genotoxicity by coffee
    • Abraham, S.K. Inhibition of in vivo genotoxicity by coffee. Food Chem. Toxicol. 1989, 27, 787-792.
    • (1989) Food Chem. Toxicol. , vol.27 , pp. 787-792
    • Abraham, S.K.1
  • 19
    • 0016437314 scopus 로고
    • The micronucleus test
    • Schmid, W. The micronucleus test. Mutat. Res. 1975, 31, 9-15.
    • (1975) Mutat. Res. , vol.31 , pp. 9-15
    • Schmid, W.1
  • 20
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95, 351-358.
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 21
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege, J.A.; Aust, S.D. Microsomal lipid peroxidation. Methods Enzymol. 1987, 52, 302-310.
    • (1987) Methods Enzymol. , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 22
    • 0022272493 scopus 로고
    • Determination of glutathione
    • Meister, A., Ed.; Academic Press
    • Anderson, M.E. Determination of glutathione. In Methods Enzymol; Meister, A., Ed.; Academic Press, 1985; 548-551.
    • (1985) Methods Enzymol. , pp. 548-551
    • Anderson, M.E.1
  • 24
    • 0016275313 scopus 로고
    • Glutathione-S-transferases, the first enzymatic step in mercapturic acid formation
    • Habig, W.H.; Pabst, M.J.; Jakoby, W.B. Glutathione-S-transferases, the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249, 130-139.
    • (1974) J. Biol. Chem. , vol.249 , pp. 130-139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 26
    • 0034027358 scopus 로고    scopus 로고
    • Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents
    • Bignami, M.; O'Driscoll, M.; Aquilina, G.; Karran, P. Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutat. Res. 2000, 462, 71-82.
    • (2000) Mutat. Res. , vol.462 , pp. 71-82
    • Bignami, M.1    O'Driscoll, M.2    Aquilina, G.3    Karran, P.4
  • 27
    • 0342940808 scopus 로고    scopus 로고
    • Detection of N-methyl-N′-nitro-N-nitrosoguanidine-induced DNA lesions in mammalian cells: Validation of comet assay against DNA unwinding technique, alkaline elution of DNA and chromosomal aberrations
    • Salmenova, D.; Gabelova, A.; Ruzekova, L.; Chalupa, I.; Harrathova, E.; Farkasova, T.; Bozsakyova, E.; Stetina, R. Detection of N-methyl-N′ -nitro-N-nitrosoguanidine-induced DNA lesions in mammalian cells: validation of comet assay against DNA unwinding technique, alkaline elution of DNA and chromosomal aberrations. Mutat. Res. 1997, 383, 243-252.
    • (1997) Mutat. Res. , vol.383 , pp. 243-252
    • Salmenova, D.1    Gabelova, A.2    Ruzekova, L.3    Chalupa, I.4    Harrathova, E.5    Farkasova, T.6    Bozsakyova, E.7    Stetina, R.8
  • 28
    • 0031565992 scopus 로고    scopus 로고
    • Induction of kinetochore positive and negative micronuclei in V79 cells by N-methyl-N′-nitro-N-nitrosoguanidine: The protective effect of the pyridoindole antioxidant stobadine
    • Horvathova, E.; Bonatti, S.; Abbondandolo, A.; Slamenova, D. Induction of kinetochore positive and negative micronuclei in V79 cells by N-methyl-N′-nitro-N-nitrosoguanidine: the protective effect of the pyridoindole antioxidant stobadine. Mutat. Res. 1997, 395, 243-247.
    • (1997) Mutat. Res. , vol.395 , pp. 243-247
    • Horvathova, E.1    Bonatti, S.2    Abbondandolo, A.3    Slamenova, D.4
  • 29
    • 0037255486 scopus 로고    scopus 로고
    • Molecular and cellular influences of butylated hydroxyanisole on Chinese hamster V79 cells treated N-methyl-N′-nitro-N-nitrosoguanidine: Antimutagenicity of butylated hydroxyanisole
    • Slamenova, D.; Horvathova, E.; Robichova, S.; Hrusovska, L.; Gabelova, A.; Kleibl, K.; Jakubikova, J.; Sedlak, J. Molecular and cellular influences of butylated hydroxyanisole on Chinese hamster V79 cells treated N-methyl-N′-nitro-N-nitrosoguanidine: antimutagenicity of butylated hydroxyanisole. Environ. Mol. Mutagen. 2003, 41, 28-36.
    • (2003) Environ. Mol. Mutagen , vol.41 , pp. 28-36
    • Slamenova, D.1    Horvathova, E.2    Robichova, S.3    Hrusovska, L.4    Gabelova, A.5    Kleibl, K.6    Jakubikova, J.7    Sedlak, J.8
  • 30
    • 0036605536 scopus 로고    scopus 로고
    • Production of hydroxyl free radical in the xanthine oxidase system with addition of 1-methyl-3-nitro-1-nitrosoguanidine
    • Mikuni, T.; Tatsuta, M. Production of hydroxyl free radical in the xanthine oxidase system with addition of 1-methyl-3-nitro-1-nitrosoguanidine. Free Radic. Res. 2002, 36, 641-647.
    • (2002) Free Radic. Res. , vol.36 , pp. 641-647
    • Mikuni, T.1    Tatsuta, M.2
  • 31
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher, D.; Junod, A.F. Role of oxygen free radicals in cancer development. Eur. J. Cancer 1996, 32, 30-38.
    • (1996) Eur. J. Cancer , vol.32 , pp. 30-38
    • Dreher, D.1    Junod, A.F.2
  • 32
    • 0023683410 scopus 로고
    • Toxicity of methylating agents in isolated hepatocytes
    • Reitnan, F.A.; Shertzer, H.G.; Berger, M.L. Toxicity of methylating agents in isolated hepatocytes. Biochem. Pharmacol. 1988, 37, 3183-3188.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3183-3188
    • Reitnan, F.A.1    Shertzer, H.G.2    Berger, M.L.3
  • 33
    • 0022459204 scopus 로고
    • Erythrocyte antioxidants and membrane vulnerability
    • Hebbel, R.P. Erythrocyte antioxidants and membrane vulnerability. J. Lab. Clin. Med. 1986, 107, 401-405.
    • (1986) J. Lab. Clin. Med. , vol.107 , pp. 401-405
    • Hebbel, R.P.1
  • 34
    • 0033067354 scopus 로고    scopus 로고
    • Regulation of hepatic glutathione synthesis: Current concepts and controversies
    • Lu, S.C. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 1999, 13, 1169-1173.
    • (1999) FASEB J. , vol.13 , pp. 1169-1173
    • Lu, S.C.1
  • 35
    • 0028273316 scopus 로고
    • Glutathione, ascorbate and cellular protection
    • Meister, A. Glutathione, ascorbate and cellular protection. Cancer Res. 1994, 54, 1969-1975.
    • (1994) Cancer Res. , vol.54 , pp. 1969-1975
    • Meister, A.1
  • 37
    • 0034192744 scopus 로고    scopus 로고
    • Lipid peroxidation status, somatic mutations and micronuclei in peripheral lymphocytes: A case observation on a possible interrelationship
    • Mayer, C.; Schmezer, P.; Freese, R.; Mutanen, M.; Hietanen, E.; Obe, G.; Basu, S.; Bartsch, H. Lipid peroxidation status, somatic mutations and micronuclei in peripheral lymphocytes: a case observation on a possible interrelationship. Cancer Lett. 2000, 152, 169-173.
    • (2000) Cancer Lett. , vol.152 , pp. 169-173
    • Mayer, C.1    Schmezer, P.2    Freese, R.3    Mutanen, M.4    Hietanen, E.5    Obe, G.6    Basu, S.7    Bartsch, H.8
  • 38
    • 0028293322 scopus 로고
    • DNA Markers of oxidative processes in vivo: Relevance to carcinogenesis and anticarcinogenesis
    • Simic, M.G. DNA Markers of oxidative processes in vivo: relevance to carcinogenesis and anticarcinogenesis. Cancer Res. 1994, 54, 1918s-1923s.
    • (1994) Cancer Res. , vol.54
    • Simic, M.G.1
  • 39
    • 0023338892 scopus 로고
    • The activity of N-methyl-N′-nitro-N-nitrosoguanidine in the mouse bone marrow micronucleus assay
    • Ashby, J.; Mirkowa, E. The activity of N-methyl-N′ -nitro-N-nitrosoguanidine in the mouse bone marrow micronucleus assay. Mutagenesis 1987, 2, 199-204.
    • (1987) Mutagenesis , vol.2 , pp. 199-204
    • Ashby, J.1    Mirkowa, E.2
  • 40
    • 45949113951 scopus 로고
    • Relationships among cytotoxicity, chromosomal aberrations and DNA double-strand breaks
    • Bradley, M.O.; Taylor, V.I.; Armstrong, M.J.; Galloway, S.M. Relationships among cytotoxicity, chromosomal aberrations and DNA double-strand breaks. Mutat. Res. 1987, 189, 69-79.
    • (1987) Mutat. Res. , vol.189 , pp. 69-79
    • Bradley, M.O.1    Taylor, V.I.2    Armstrong, M.J.3    Galloway, S.M.4
  • 42
    • 0032101097 scopus 로고    scopus 로고
    • Effects of neem flowers, Thai and Chinese bitter gourd, fruits and sweet basil leaves on hepatic monooxygenases and glutathione-S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats
    • Kusamran, W.R.; Ratanavila, A.; Tepsuwan, A. Effects of neem flowers, Thai and Chinese bitter gourd, fruits and sweet basil leaves on hepatic monooxygenases and glutathione-S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats. Food Chem. Toxicol. 1998, 36, 475-484.
    • (1998) Food Chem. Toxicol. , vol.36 , pp. 475-484
    • Kusamran, W.R.1    Ratanavila, A.2    Tepsuwan, A.3
  • 43
    • 0034698482 scopus 로고    scopus 로고
    • Rapid and sensitive analysis of azadirachtin and related triterpenoids from neem (Azadirachta indica) by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
    • Schaaf, O.; Jarvis, A.P.; van der Esch, S.A.; Giagnacovo, G.; Oldham, N.J. Rapid and sensitive analysis of azadirachtin and related triterpenoids from neem (Azadirachta indica) by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J. Chromatogr. A. 2000, 886, 89-97.
    • (2000) J. Chromatogr. A , vol.886 , pp. 89-97
    • Schaaf, O.1    Jarvis, A.P.2    Van Der Esch, S.A.3    Giagnacovo, G.4    Oldham, N.J.5
  • 44
    • 0001477712 scopus 로고
    • Chemical and biological investigations on Azadirachta indica (the neem tree)
    • Govindachari, T.R. Chemical and biological investigations on Azadirachta indica (the neem tree). Current Sci. 1992, 63, 117-122.
    • (1992) Current Sci. , vol.63 , pp. 117-122
    • Govindachari, T.R.1
  • 45
    • 0036007615 scopus 로고    scopus 로고
    • Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)
    • Blasiak, J.; Trzeciak, A.; Gasiorowska, A.; Drzewoski, J.; Malecka-Panas, E. Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N′ -nitro-N-nitrosoguanidine (MNNG). Plant Foods Hum. Nutr. 2002, 57, 53-61.
    • (2002) Plant Foods Hum. Nutr. , vol.57 , pp. 53-61
    • Blasiak, J.1    Trzeciak, A.2    Gasiorowska, A.3    Drzewoski, J.4    Malecka-Panas, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.