Keratinocyte proliferation, differentiation, and apoptosis-Differential mechanisms of regulation by curcumin, EGCG and apigenin

Toxicology and Applied Pharmacology

Volumn 224, Issue 3, 2007, Pages 214-219

  Balasubramanian, Sivaprakasam ^a   Eckert, Richard L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apigenin; Apoptosis; Chemoprevention; Curcumin; EGCG; Epidermis; Involucrin; Keratinocyte differentiation; TPA; Turmeric

Indexed keywords

APIGENIN; CASPASE 14; CURCUMIN; DNA; EPIGALLOCATECHIN GALLATE; INVOLUCRIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; KERATINOCYTE; REVIEW; TEA;

ANTICARCINOGENIC AGENTS; APIGENIN; APOPTOSIS; CATECHIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CURCUMIN; HUMANS; KERATINOCYTES; PROTEIN KINASES;

CURCUMA LONGA;

EID: 35348855249     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.03.020     Document Type: Review

References (47)

1. Agarwal C., Efimova T., Welter J.F., Crish J.F., and Eckert R.L. CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester. J. Biol. Chem. 274 (1999) 6190-6194
2. Balasubramanian S., and Eckert R.L. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J. Biol. Chem. 279 (2004) 24007-24014
3. Balasubramanian S., and Eckert R.L. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J. Biol. Chem. (2006)
4. Balasubramanian S., Efimova T., and Eckert R.L. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J. Biol. Chem. 277 (2002) 1828-1836
5. Balasubramanian S., Sturniolo M.T., Dubyak G.R., and Eckert R.L. Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis. Carcinogenesis 26 (2005) 1100-1108
6. Balasubramanian S., Zhu L., and Eckert R.L. Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J. Biol. Chem. 281 (2006) 36162-36172
7. Banks E.B., Crish J.F., Welter J.F., and Eckert R.L. Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites. Biochem. J. 331 Pt 1 (1998) 61-68
8. Barthelman M., Bair III W.B., Stickland K.K., Chen W., Timmermann B.N., Valcic S., Dong Z., and Bowden G.T. (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis 19 (1998) 2201-2204
9. Birt D.F., Pelling J.C., Nair S., and Lepley D. Diet intervention for modifying cancer risk. Prog. Clin. Biol. Res. 395 (1996) 223-234
10. Birt D.F., Mitchell D., Gold B., Pour P., and Pinch H.C. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res. 17 (1997) 85-91
11. Chen W., Dong Z., Valcic S., Timmermann B.N., and Bowden G.T. Inhibition of ultraviolet B-induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line. Mol. Carcinog. 24 (1999) 79-84
12. Chung J.Y., Huang C., Meng X., Dong Z., and Yang C.S. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res. 59 (1999) 4610-4617
13. Crish J.F., Howard J.M., Zaim T.M., Murthy S., and Eckert R.L. Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype. Differentiation 53 (1993) 191-200
14. Crish J.F., Zaim T.M., and Eckert R.L. The distal regulatory region of the human involucrin promoter is required for expression in epidermis. J. Biol. Chem. 273 (1998) 30460-30465
15. Crish J.F., Bone F., Banks E.B., and Eckert R.L. The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. Oncogene 21 (2002) 738-747
16. Dong Z., Ma W., Huang C., and Yang C.S. Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. Cancer Res. 57 (1997) 4414-4419
17. Eckert R.L., Crish J.F., Efimova T., Dashti S.R., Deucher A., Bone F., Adhikary G., Huang G., Gopalakrishnan R., and Balasubramanian S. Regulation of involucrin gene expression. J. Invest. Dermatol. 123 (2004) 13-22
18. Efimova T., and Eckert R.L. Regulation of human involucrin promoter activity by novel protein kinase C isoforms. J. Biol. Chem. 275 (2000) 1601-1607
19. Efimova T., LaCelle P., Welter J.F., and Eckert R.L. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J. Biol. Chem. 273 (1998) 24387-24395
20. Efimova T., Deucher A., Kuroki T., Ohba M., and Eckert R.L. Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277 (2002) 31753-31760
21. Efimova T., Broome A.M., and Eckert R.L. A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J. Biol. Chem. 278 (2003) 34277-34285
22. Efimova T., Broome A.M., and Eckert R.L. Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol. Cell. Biol. 24 (2004) 8167-8183
23. Gupta S., Hastak K., Afaq F., Ahmad N., and Mukhtar H. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 23 (2004) 2507-2522
24. Hsu S., Yamamoto T., Borke J., Walsh D.S., Singh B., Rao S., Takaaki K., Nah-Do N., Lapp C., Lapp D., Foster E., Bollag W.B., Lewis J., Wataha J., Osaki T., and Schuster G. Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14. J. Pharmacol. Exp. Ther. 312 (2005) 884-890
25. Huang M.T., Ma W., Yen P., Xie J.G., Han J., Frenkel K., Grunberger D., and Conney A.H. Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18 (1997) 83-88
26. Huang M.T., Newmark H.L., and Frenkel K. Inhibitory effects of curcumin on tumorigenesis in mice. J. Cell. Biochem., Suppl. 27 (1997) 26-34
27. Huang M.T., Newmark H.L., and Frenkel K. Inhibitory effects of curcumin on tumorigenesis in mice. J. Cell. Biochem., Suppl. 27 (1997) 26-34
28. Huang M.T., Smart R.C., Wong C.Q., and Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48 (1988) 5941-5946
29. Huang M.T., Smart R.C., Wong C.Q., and Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48 (1988) 5941-5946
30. Katiyar S.K., Mohan R.R., Agarwal R., and Mukhtar H. Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis 18 (1997) 497-502
31. Katiyar S.K., Afaq F., Perez A., and Mukhtar H. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 22 (2001) 287-294
32. Khan N., Afaq F., Saleem M., Ahmad N., and Mukhtar H. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 66 (2006) 2500-2505
33. 2-treated cells and its activation by tyrosine kinase in vitro. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 6587-6592
34. Lepley D.M., Li B., Birt D.F., and Pelling J.C. The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes. Carcinogenesis 17 (1996) 2367-2375
35. Limtrakul P., Anuchapreeda S., Lipigorngoson S., and Dunn F.W. Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. BMC Cancer 1 (2001) 1
36. Lin, J.K., Chen, Y.C., Huang, Y.T., Lin-Shiau, S.Y., 1997. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J. Cell. Biochem., Suppl. 28-29:39-48, 39-48.
37. Lu Y.P., Lou Y.R., Xie J.G., Peng Q.Y., Liao J., Yang C.S., Huang M.T., and Conney A.H. Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12455-12460
38. Nemes Z., and Steinert P.M. Bricks and mortar of the epidermal barrier. Exp. Mol. Med. 31 (1999) 5-19
39. Nomura M., Ma W.Y., Huang C., Yang C.S., Bowden G.T., Miyamoto K., and Dong Z. Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol. Carcinog. 28 (2000) 148-155
40. Ross J.A., and Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 22 (2002) 19-34
41. Sarkar F.H., and Li Y. Cell signaling pathways altered by natural chemopreventive agents. Mutat. Res. 555 (2004) 53-64
42. Shishodia S., Sethi G., and Aggarwal B.B. Curcumin: getting back to the roots. Ann. N. Y. Acad. Sci. 1056 (2005) 206-217
43. Singletary K., MacDonald C., Iovinelli M., Fisher C., and Wallig M. Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. Carcinogenesis 19 (1998) 1039-1043
44. Stoner G.D., and Mukhtar H. Polyphenols as cancer chemopreventive agents. J. Cell. Biochem., Suppl. 22 (1995) 169-180
45. Van Dross R.T., Hong X., and Pelling J.C. Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Mol. Carcinog. 44 (2005) 83-91
46. Wei H., Tye L., Bresnick E., and Birt D.F. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 50 (1990) 499-502
47. Welter J.F., Crish J.F., Agarwal C., and Eckert R.L. Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J. Biol. Chem. 270 (1995) 12614-12622