Suppression of inflammation response by a novel A 3 adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-κB signaling

Immunobiology

Volumn 216, Issue 9, 2011, Pages 997-1003

  Lee, Hak Sun ^a   Chung, Hwa Jin ^b   Lee, Hyuk Woo ^a   Jeong, Lak Shin ^a   Lee, Sang Kook ^b  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

A 3AR agonist; Anti inflammation; Endotoxemia; IL 1 ; INOS; Thio Cl IB MECA; TNF

Indexed keywords

2 CHLORO N6 (3 IODOBENZYL) 4' THIOADENOSINE 5' N METHYLURONAMIDE; ADENOSINE RECEPTOR STIMULATING AGENT; BETA CATENIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION;

ADENOSINE; ADENOSINE A3 RECEPTOR AGONISTS; ANIMALS; BETA CATENIN; CELL LINE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; HUMANS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A3; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960848582     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.03.008     Document Type: Article

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