Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action

Indian Journal of Experimental Biology

Volumn 47, Issue 2, 2009, Pages 113-120

  Preethia, Korengath Chandran ^a   Kuttanb, Girija ^a   Kuttan, Ramadasan ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Anti inflammatory agents; Calendula officinalis; Cyclooxygenase 2; Proinflammatory cytokines

Indexed keywords

ANIMALIA; CALENDULA; CALENDULA OFFICINALIS; MUS;

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; CYTOKINE; PLANT EXTRACT; PTGS2 PROTEIN, MOUSE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CALENDULA; CELL LINE; CELL SHAPE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FLOWER; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; MALE; MOUSE; PATHOLOGY; PHYTOTHERAPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CALENDULA; CELL LINE; CELL SHAPE; CYCLOOXYGENASE 2; CYTOKINES; FLOWERS; GENE EXPRESSION; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 69249221647     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Philip M, Rowley D A & Schreiber H, Inflammation as a tumor promoter in cancer induction Seminars in Cancer Biol, 14 (2004) 433.
2. Virani S S, Polsani V R & Nambi V, Novel markers of inflammation in atherosclerosis, Curr Atheroscler Rep, 10 (2008) 164.
3. Maiti R & Agrawal N K, Atherosclerosis in diabetes mellitus: role of inflammation, Indian J Med Sci, 61 (2007) 292.
4. Ohshima H & Bartsch H, Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis, Mutat Res, 305 (1994) 253.
5. Stevens R J, Douglas K M, Saratzis A N & Kitas G D, Inflammation and atherosclerosis in rheumatoid arthritis, Expert Rev Mol Med, 7 (2005) 1.
6. Hofeseth L J & Ying L, Identifying and defusing weapons of mass inflammation in carcinogenesis, Biochem Biophys Acta, 1765 (2006) 74.
7. Oshima H, Tatemichi M & Sawa T, Chemical basis of inflammation induced carcinogenesis, Arch Biochem Biophys, 417 (2000) 3.
8. Bondarenko V M, Vinogradov N A & Maleev V V, The antimicrobial activity of nitric oxide and its role in the infectious process, Zh Mikrobiol Epidemiol Immunobiol, 5 (1999) 61.
9. Krishnamoorthy S & Honn K V, Inflammation and disease progression, Cancer Metastasis Rev, 25 (2006) 481.
10. Dedona P C & Tannenbaum S R, Reactive nitrogen species in the chemical biology of inflammation, Arch Biochem Biophys, 423 (2004) 12.
11. Coussens L M & Werb Z, Inflammation and cancer, Nature, 420 (2002) 860.
12. Surh Y J, NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities, Asia Pac J Clin Nutr, 17 (2008) 269.
13. Gupta S S, Prospects and perspectives of natural plants products in medicine, Indian J Pharmacol, 26 (1994) 1.
14. Basch E, Bent S, Foppa I, Haskmi, S, Kroll D, Mele M, Szapary P, Ulbricht C, Vora M & Yong S, Marigold (Calendula officinalis L.): An evidence-based systematic review by the Natural Standard Research Collaboration, J Herbal Pharmacother, 6 (2006) 135.
15. Dumenil G, Chemli R & Balausard G, Evaluation of antibacterial properties of Calendula officinalis flowers and mother homeopathic tinctures of Calendula officinalis, Ann Pharma Fran, 38 (1980) 493.
16. Kasiram K, Sakharkar P R & Patil A T, Antifungal activity of Calendula officinalis, Indian J Pharm Sci, 6 (2000) 464.
17. Barbour E K, Sagherian V, Talhouk S, Talhouk R, Farran M T, Sleiman F T & Harakeh S, Evaluation of homeopathy in broiler chickens exposed to live viral vaccines and administered Calendula officinalis extract, Med Sci Monit, 10(8) (2004) 281.
18. Preethi K C , Kuttan G & Kuttan R, Antioxidant potential of an extract of Calendula officinalis in vitro and in vivo, Pharm Biol, 44 (9) (2006) 691.
19. Committee on Pharmacopoeia of the American Institute of Homeopathy, The Homeopathic Pharmacopoeia of the United States, 6th edition, (Otis Clapp & Son, Inc., Boston) 1954, 39.
20. Winter C A, Risly E A & Nuss C W, Carrageenan induced edema in hind paw of the rats- an assay for antiinflammatory drugs, Proc Soc Exp Biol Med, 111(1962) 544.
21. Maity T K, Mandal S C & Mukherjee P K, Studies on antiinflammatory effect of Cassia tora leaf extract (Fam. Leguminosae), Phytother Res, 12 (1998) 221.
22. Chau T T, Analgesic testing in animal models, in Pharmacological methods in the control of inflammations (Alan R Liss Inc, New York), 1989, 448.
23. Sugarman B J, Agarwal B B, Hass P E, Figari I S, Palladino MA & Shepard H M, Recombinant human tumor necrosis factor cells in vitro, Science, 230 (1985) 943.
24. Tomkins P, Cooper K, Webber D & Bower G, The L929 cell bioassay for murine tumor necrosis factor is not influenced by other cytokines, J Immmunol Methods, 151 (1992) 313.
25. Thejass P & Kuttan G, Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production, Nitric Oxide, 16 (2007) 247.
26. Smolinski A T, Pestka J J, Comparative effects of the herbal constituent parthenolide (fever few) on lipopolysaccharide induced inflammatory gene expression in murine spleen and liver, J Inflamm, 2 (2005) 6.
27. Chomczynski P & Sacchi N, The single step method for RNA isolation by acid guanidium thiocyanate-phenolchloroform extraction: twenty something years on, Nature Protocols, 1 (2006) 581.
28. Larsen G L & Henson P M, Mediators of inflammation, Ann Rev Immunol, 1 (1983) 335.
29. Brooks P M & Day O, Non-steroidal anti-inflammatory drugs: differences and similarities, N Engl J Med, 324 (1991) 1716.
30. Vane J & Booting R, Inflammation and the mechanism of action of anti-inflammatory drugs, FASEB J, 1 (1987) 89.
31. Ghosh M N, Banerjee, R H & Mukherjee S K, Capillary permeability increasing property of hyaluronidase in rat, Indian J Physiol Pharmacol, 7 (1963) 17.
32. Greenwald R A, Animal model for evaluation of arthric drugs, Meth Food Clin Pharmacol, 13 (1991) 75.
33. Robbins R A, Springall D R, Warren J B, Keon O J, Buttery L D, Wilson A J, Adcock I M, Moreno V R, Moncada S, & Polac J, Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation, Biochem Biophys Res Commun, 198 (1994) 835.
34. Iles K E & Forman H J, Macrophage signaling and respiratory burst, Immunol Res, 26 (2002) 95.
35. Kundu J K & Surh Y J, Breaking the relay in deregulated signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals, Mut Res, 591 (2005) 123.
36. Matysik G, Wojciak-Kosior M & Paduch R, The influence of Calendula officinalis flos extract on cell cultures and the chromatographic analysis of extracts, J Pharm Biomed Anal, 38(2) (2005) 285.
37. Kishimoto S, Maoka T, Sumitomo K & Ohmiya A, Analysis of carotenoid composition in petals of Calendula (Calendula officinalis L.), Biosci Biotechno Biochem, 69 (11) (2005) 2122.
38. Nishino H, Murakosh M, Ii T, Takemura M, Kuchide M, Kanazawa M, Mou X Y, Wada S, Masuda M, Ohsaka Y, Yogosawa S, Satomi Y & Jinno K, Carotenoids in cancer chemoprevention, Cancer Metastasis Rev, 21 (2002) 257.
39. Böhm F, Haley J, Truscott T G & Schalch W, Cellular bound beta-carotene quenches singlet oxygen in man, J Photochem Photobiol, 21 (1993) 219.
40. Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker P B, Hunziker W, Goralczyk R & Wertz K, Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate, FASEB J, 19 (2) (2005) 272.