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Volumn 8, Issue 1, 2006, Pages

The PI3K-NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A3 RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N(6)-(3-IODOBENZYL)-5'-N-METHYLCARBOXAMIDOADENOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL PEPTIDE;

EID: 70449564383     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1887     Document Type: Article
Times cited : (94)

References (39)
  • 1
    • 0027983055 scopus 로고
    • Adenosine, an endogenous anti-inflammatory agent
    • Cronstein BN: Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 1994, 76:5-13.
    • (1994) J Appl Physiol , vol.76 , pp. 5-13
    • Cronstein, B.N.1
  • 2
  • 3
    • 0037453358 scopus 로고    scopus 로고
    • The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis
    • Mabley J, Soriano F, Pacher P, Hasko G, Marton A, Wallace R, Salzman A, Szabo C: The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis. Eur J Pharmacol 2003, 466 323-329.
    • (2003) Eur J Pharmacol , vol.466 , pp. 323-329
    • Mabley, J.1    Soriano, F.2    Pacher, P.3    Hasko, G.4    Marton, A.5    Wallace, R.6    Salzman, A.7    Szabo, C.8
  • 4
    • 0038604758 scopus 로고    scopus 로고
    • Pharmacology and therapeutic applications of A3 receptor subtype
    • Fishman P, Bar-Yehuda S: Pharmacology and therapeutic applications of A3 receptor subtype. Curr Top Med Chem 2003, 3:463-469.
    • (2003) Curr Top Med Chem , vol.3 , pp. 463-469
    • Fishman, P.1    Bar-Yehuda, S.2
  • 5
    • 0036839622 scopus 로고    scopus 로고
    • Adenosine up-regulates cyclooxygenase-2 in human granulocytes: Impact on the balance of eicosanoid generation
    • Pouliot M, Fiset ME, Massé M, Naccache PH, Borgeat P: Adenosine up-regulates cyclooxygenase-2 in human granulocytes: Impact on the balance of eicosanoid generation. J Immunol 2002, 169 5279-5286.
    • (2002) J Immunol , vol.169 , pp. 5279-5286
    • Pouliot, M.1    Fiset, M.E.2    Massé, M.3    Naccache, P.H.4    Borgeat, P.5
  • 6
    • 0030588630 scopus 로고    scopus 로고
    • Adenosine receptor agonists differentially regulate IL-10, TNFalpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice
    • Hasko G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES: Adenosine receptor agonists differentially regulate IL-10, TNFalpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice J Immunol 1996, 157:4634-4640.
    • (1996) J Immunol , vol.157 , pp. 4634-4640
    • Hasko, G.1    Szabo, C.2    Nemeth, Z.H.3    Kvetan, V.4    Pastores, S.M.5    Vizi, E.S.6
  • 7
    • 0033994680 scopus 로고    scopus 로고
    • Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis
    • Sung JY, Hong JH, Kang HS, Choi I, Lim SD, Lee JK, Seok JH, Lee JH, Hur GM: Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Immunopharmacology 2000, 47:35-44.
    • (2000) Immunopharmacology , vol.47 , pp. 35-44
    • Sung, J.Y.1    Hong, J.H.2    Kang, H.S.3    Choi, I.4    Lim, S.D.5    Lee, J.K.6    Seok, J.H.7    Lee, J.H.8    Hur, G.M.9
  • 8
    • 0033166175 scopus 로고    scopus 로고
    • Sites of action for future therapy: An adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice
    • Cronstein BN, Montesinos MC, Weissmann G: Sites of action for future therapy: An adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice Osteoarthritis Cartilage 1999, 7:361-363.
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 361-363
    • Cronstein, B.N.1    Montesinos, M.C.2    Weissmann, G.3
  • 9
    • 0034096901 scopus 로고    scopus 로고
    • Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: Evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis
    • Montesinos MC, Yap JS, Desai A, Posadas I, McCrary CT, Cronstein BN: Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis Rheum 2000, 43:656-663.
    • (2000) Arthritis Rheum , vol.43 , pp. 656-663
    • Montesinos, M.C.1    Yap, J.S.2    Desai, A.3    Posadas, I.4    McCrary, C.T.5    Cronstein, B.N.6
  • 11
    • 0031691973 scopus 로고    scopus 로고
    • Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists
    • Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, Hasko G: Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists Br J Pharmacol 1998, 125:379-387.
    • (1998) Br J Pharmacol , vol.125 , pp. 379-387
    • Szabo, C.1    Scott, G.S.2    Virag, L.3    Egnaczyk, G.4    Salzman, A.L.5    Shanley, T.P.6    Hasko, G.7
  • 14
    • 0036841034 scopus 로고    scopus 로고
    • Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2
    • Schutle G, Fredholm BB: Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. Mol Pharmacol 2002, 62(5):1137-1146.
    • (2002) Mol Pharmacol , vol.62 , Issue.5 , pp. 1137-1146
    • Schutle, G.1    Fredholm, B.B.2
  • 15
    • 0037030495 scopus 로고    scopus 로고
    • Evidence for involvement of Wnt signaling pathway in IBMECA mediated suppression of melanoma cells
    • Fishman P, Madi L, Bar-Yehuda S, Barer F, Del Valle L, Khalili K: Evidence for involvement of Wnt signaling pathway in IBMECA mediated suppression of melanoma cells. Oncogene 2002, 21:4060-4064.
    • (2002) Oncogene , vol.21 , pp. 4060-4064
    • Fishman, P.1    Madi, L.2    Bar-Yehuda, S.3    Barer, F.4    Del Valle, L.5    Khalili, K.6
  • 17
    • 0142211261 scopus 로고    scopus 로고
    • A3 adenosine receptor activation in melanoma cells: Association between receptor fate and tumor growth inhibition
    • Madi L, Bar-Yehuda S, Barer F, Ardon E, Ochaion A, Fishman P: A3 adenosine receptor activation in melanoma cells: Association between receptor fate and tumor growth inhibition. J Biol Chem 2003, 278:42121-42130.
    • (2003) J Biol Chem , vol.278 , pp. 42121-42130
    • Madi, L.1    Bar-Yehuda, S.2    Barer, F.3    Ardon, E.4    Ochaion, A.5    Fishman, P.6
  • 18
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and inflammation
    • Hanada T, Yoshimura A: Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002, 13:413-421.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 413-421
    • Hanada, T.1    Yoshimura, A.2
  • 19
    • 0030851109 scopus 로고    scopus 로고
    • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages
    • Shackelford RE, Alford PB, Xue Y, Thai SF, Adams DO, Pizzo S: Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. Mol Pharmacol 1997, 52:421-429.
    • (1997) Mol Pharmacol , vol.52 , pp. 421-429
    • Shackelford, R.E.1    Alford, P.B.2    Xue, Y.3    Thai, S.F.4    Adams, D.O.5    Pizzo, S.6
  • 21
    • 0037840263 scopus 로고    scopus 로고
    • The role of apoptosis in rheumatoid arthritis
    • Liu H, Pope RM: The role of apoptosis in rheumatoid arthritis. Curr Opin Pharmacol 2003, 3:317-322.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 317-322
    • Liu, H.1    Pope, R.M.2
  • 22
    • 15444352073 scopus 로고    scopus 로고
    • Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5′-N-ethyluronamide as A1 and A3 adenosine receptor agonists
    • Baraldi PG, Cacciari B, Pineda de Las Infantas MJ, Romagnoli R, Spalluto G, Volpini R, Costanzi S, Vittori S, Cristalli G, Melman N, et al. Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5′-N-ethyluronamide as A1 and A3 adenosine receptor agonists. J Med Chem 1998, 41:3174-3185.
    • (1998) J Med Chem , vol.41 , pp. 3174-3185
    • Baraldi, P.G.1    Cacciari, B.2    Pineda de Las Infantas, M.J.3    Romagnoli, R.4    Spalluto, G.5    Volpini, R.6    Costanzi, S.7    Vittori, S.8    Cristalli, G.9    Melman, N.10
  • 23
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, Linden J: International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001, 53:527-552.
    • (2001) Pharmacol Rev , vol.53 , pp. 527-552
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 25
    • 0042807352 scopus 로고    scopus 로고
    • Targeting the A3 adenosine receptor for cancer therapy: Inhibition of prostate carcinoma cell growth by A3AR agonist
    • Fishman P, Bar-Yehuda S, Ardon E, Rath-Wolfson L, Barrer F, Ochaion A, Madi L: Targeting the A3 adenosine receptor for cancer therapy: inhibition of prostate carcinoma cell growth by A3AR agonist. Anticancer Res 2003, 23:2077-2083.
    • (2003) Anticancer Res , vol.23 , pp. 2077-2083
    • Fishman, P.1    Bar-Yehuda, S.2    Ardon, E.3    Rath-Wolfson, L.4    Barrer, F.5    Ochaion, A.6    Madi, L.7
  • 26
    • 1942532883 scopus 로고    scopus 로고
    • An agonist to the A(3) adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3beta and NF-kappaB
    • Fishman P, Bar-Yehuda S, Ohana G, Barer F, Ochaion A, Erlanger A, Madi L: An agonist to the A(3) adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3beta and NF-kappaB. Oncogene 2004, 23(14):2465-2471.
    • (2004) Oncogene , vol.23 , Issue.14 , pp. 2465-2471
    • Fishman, P.1    Bar-Yehuda, S.2    Ohana, G.3    Barer, F.4    Ochaion, A.5    Erlanger, A.6    Madi, L.7
  • 28
    • 0033628571 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinasT dependent pathways: The role in control of cell growth, survival, and malignant transformation
    • Krasilnikov MA: Phosphatidylinositol-3 kinasT dependent pathways: the role in control of cell growth, survival, and malignant transformation Biochemistry (Mosc) 2000, 65:59-67.
    • (2000) Biochemistry (Mosc) , vol.65 , pp. 59-67
    • Krasilnikov, M.A.1
  • 29
    • 0037771321 scopus 로고    scopus 로고
    • Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways
    • Wang K, Scheel-Toellner D, Wong SH, Craddock R, Caamano J, Akbar AN, Salmon M, Lord JM: Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways. J Immunol 2003, 171:1035-1041.
    • (2003) J Immunol , vol.171 , pp. 1035-1041
    • Wang, K.1    Scheel-Toellner, D.2    Wong, S.H.3    Craddock, R.4    Caamano, J.5    Akbar, A.N.6    Salmon, M.7    Lord, J.M.8
  • 30
    • 0034469496 scopus 로고    scopus 로고
    • Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
    • Pap T, Muller-Ladner U, Gay RE, Gay S: Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000, 2361-367.
    • (2000) Arthritis Res , vol.2 , pp. 361-367
    • Pap, T.1    Muller-Ladner, U.2    Gay, R.E.3    Gay, S.4
  • 32
    • 0037354119 scopus 로고    scopus 로고
    • Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway
    • Stoica BA, Movsesyan VA, Lea PM, Faden AI: Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci 2003, 22:365-382.
    • (2003) Mol Cell Neurosci , vol.22 , pp. 365-382
    • Stoica, B.A.1    Movsesyan, V.A.2    Lea, P.M.3    Faden, A.I.4
  • 35
    • 0033559904 scopus 로고    scopus 로고
    • IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: A mechanism of macrophage deactivation
    • Xaus J, Mirabet M, Lloberas J, Soler C, Lluis C, Franco R, Celada A: IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: A mechanism of macrophage deactivation. J Immunol 1999, 162:3607-3614.
    • (1999) J Immunol , vol.162 , pp. 3607-3614
    • Xaus, J.1    Mirabet, M.2    Lloberas, J.3    Soler, C.4    Lluis, C.5    Franco, R.6    Celada, A.7
  • 37
    • 0034944752 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor alphamediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt
    • Zhang HG, Wang Y, Xie JF, Liang X, Liu D, Yang P, Hsu HC, Ray RB, Mountz JD: Regulation of tumor necrosis factor alphamediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis Rheum 2001, 44:1555-1567.
    • (2001) Arthritis Rheum , vol.44 , pp. 1555-1567
    • Zhang, H.G.1    Wang, Y.2    Xie, J.F.3    Liang, X.4    Liu, D.5    Yang, P.6    Hsu, H.C.7    Ray, R.B.8    Mountz, J.D.9
  • 39
    • 0142027806 scopus 로고    scopus 로고
    • Targeting I kappa B kinase for the treatment of inflammatory and other disorders
    • Burke JR: Targeting I kappa B kinase for the treatment of inflammatory and other disorders. Curr Opin Drug Discov Devel 2003, 6(5):720-728.
    • (2003) Curr Opin Drug Discov Devel , vol.6 , Issue.5 , pp. 720-728
    • Burke, J.R.1


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