Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

ChemMedChem

Volumn 6, Issue 8, 2011, Pages 1459-1470

  Fletcher, Steven ^a   Page, Brent D G ^a   Zhang, Xialoei ^b   Yue, Peibin ^b   Li, Zhi Hua ^c   Sharmeen, Sumaiya ^c   Singh, Jagdeep ^a   Zhao, Wei ^b   Schimmer, Aaron D ^c   Trudel, Suzanne ^c   Turkson, James ^b   Gunning, Patrick T ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Antitumor agents; Molecular recognition; Molecular therapeutics; Protein protein interactions; Stat3

Indexed keywords

ANTINEOPLASTIC AGENT; SALICYLIC ACID; STAT3 PROTEIN; STAT3 PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA BINDING; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DIMERIZATION; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; SALICYLIC ACID; SRC HOMOLOGY DOMAINS; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960663641     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100194     Document Type: Article

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