Disruption of transcriptionally active stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: Potent in vitro and tumor cell activities

ChemBioChem

Volumn 10, Issue 12, 2009, Pages 1959-1964

  Fletcher, Steven ^a   Singh, Jagdeep ^a   Zhang, Xiaolei ^b   Yue, Peibin ^b   Page, Brent D G ^a   Sharmeen, Sumaiya ^c   Shahani, Vijay M ^a   Zhao, Wei ^b   Schimmer, Aaron D ^c   Turkson, James ^b   Gunning, Patrick T ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Antitumor agents; Molecular recognition; Molecular therapeutics; Protein protein interactions; Stat3

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN INHIBITOR OF ACTIVATED STAT; S 31 201; SALICYLIC ACID DERIVATIVE; SF 1 066; SF 1 068; SF 1 083; SF 1 087; SF 1 121; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG STRUCTURE; HUMAN; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; TUMOR CELL;

AMINOSALICYLIC ACIDS; BENZENESULFONATES; CELL PROLIFERATION; DIMERIZATION; HUMANS; MODELS, MOLECULAR; NEOPLASMS; SALICYLIC ACID; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR;

EID: 70349558529     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900172     Document Type: Article

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