Intrinsic proton-donating power of zinc-bound water in a carbonic anhydrase active site model estimated by NMR

Journal of the American Chemical Society

Volumn 133, Issue 29, 2011, Pages 11331-11338

  Lesnichin, Stepan B ^a,b   Shenderovich, Ilya G ^a,b   Muljati, Titin ^a,d   Silverman, David ^c   Limbach, Hans Heinrich ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; APROTIC; BIOLOGICAL FUNCTIONS; ENZYME REACTION; HYDROBORATES; LIQUID STATE; METALLOENZYMES; ORGANOMETALLIC COMPLEX; PENTAFLUOROPHENYL; PROTON DONORS;

BORON; BORON COMPOUNDS; CARBOXYLIC ACIDS; COMPLEXATION; HYDROGEN; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANOMETALLICS; OXYGEN; PROTONS; ZINC; ZINC COMPOUNDS;

CARBONIC ANHYDRASE;

2,4,6 TRIMETHYLPYRIDINE HYDROGEN; CARBONATE DEHYDRATASE; CARBOXYLIC ACID DERIVATIVE; METAL COMPLEX; NITRIC OXIDE DONOR; NITROGEN; OXYGEN; PROTON; UNCLASSIFIED DRUG; WATER; ZINC;

[AQUATRIS(PENTAFLUOROPHENYL)BORON]; ARTICLE; CHEMICAL BOND; CHEMICAL MODEL; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME MECHANISM; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; WATER; ZINC;

EID: 79960570663     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203478j     Document Type: Article

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