Glutathione selectively inhibits Doxorubicin induced phosphorylation of p53Ser15, caspase dependent ceramide production and apoptosis in human leukemic cells

Biochemical and Biophysical Research Communications

Volumn 411, Issue 1, 2011, Pages 1-6

  Thayyullathil, Faisal ^a   Chathoth, Shahanas ^a   Kizhakkayil, Jaleel ^a   Galadari, Alaa ^a   Hago, Abdulkader ^a   Patel, Mahendra ^a   Galadari, Sehamuddin ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Apoptosis; Caspase; Ceramide; Doxorubicin; GSH; P53; P53Ser15

Indexed keywords

ANTIOXIDANT; CASPASE; CERAMIDE; DOXORUBICIN; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; SERINE;

APOPTOSIS; ARTICLE; CYTOTOXICITY; DNA FRAGMENTATION; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CASPASES; CERAMIDES; DOXORUBICIN; GLUTATHIONE; HUMANS; JURKAT CELLS; LEUKEMIA; PHOSPHORYLATION; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA;

EID: 79960565704     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.156     Document Type: Article

References (41)

1. Circu M.L., Aw T.Y. Glutathione and apoptosis. Free Radic. Res. 2008, 42:689-706.
2. Liu B., Andrieu-Abadie N., Levade T., Zhang P., Obeid L.M., AHannun Y. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J. Biol. Chem. 1998, 273:11313-11320.
3. Thayyullathil F., Chathoth S., Hago A., Patel M., Galadari S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic. Biol. Med. 2008, 45:1403-1412.
4. Friesen C., Kiess Y., Debatin K.M. Critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death Differ. 2004, 11:S73-S85.
5. Chathoth S., Thayyullathil F., Hago A., Shahin A., Patel M., Galadari S. UVC-induced apoptosis in Dubca cells is independent of JNK activation and p53(Ser-15) phosphorylation. Biochem. Biophys. Res. Commun. 2009, 383:426-432.
6. Kemp C.J., Sun S., Gurley K.E. P53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Res. 2001, 61:327-332.
7. Liu M., Dhanwada K.R., Birt D.F., Hecht S., Pelling J.C. Increase in p53 protein half-life in mouse keratinocytes following UV-B irradiation. Carcinogenesis 1994, 15:1089-1092.
8. Siliciano J.D., Canman C.E., Taya Y., Sakaguchi K., Appella E., Kastan M.B. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 1997, 11:3471-3481.
9. She Q.B., Chen N., Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J. Biol. Chem. 2000, 275:20444-20449.
10. Dbaibo G.S., Pushkareva M.Y., Rachid R.A., et al. p53-dependent ceramide response to genotoxic stress. J. Clin. Invest. 1998, 102:329-339.
11. Kim M.Y., Linardic C., Obeid L.M., Hannun Y.A. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J. Biol. Chem. 1991, 266:484-489.
12. Cifone M.G., De Maria R., Roncaioli P., et al. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 1994, 180:1547-1552.
13. Haimovitz-Friedman A., Kan C.C., Ehleiter D., et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 1994, 180:525-535.
14. Yabu T., Imamura S., Yamashita M., Okazaki T. Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis. J. Biol. Chem. 2008, 283:29971-29982.
15. Jarvis W.D., Grant S. The role of ceramide in the cellular response to cytotoxic agents. Curr. Opin. Oncol. 1998, 10:552-559.
16. Pronk G.J., Ramer K., Amiri P., Williams L.T. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science 1996, 271:808-810.
17. Dbaibo G.S., Perry D.K., Gamard C.J., et al. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 1997, 185:481-490.
18. Genestier L., Prigent A.F., Paillot R., et al. Caspase-dependent ceramide production in Fas- and HLA class I-mediated peripheral T cell apoptosis. J. Biol. Chem. 1998, 273:5060-5066.
19. Lafont E., Milhas D., Carpentier S., et al. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ. 2010, 17:642-654.
20. Watanabe M., Kitano T., Kondo T., et al. Increase of nuclear ceramide through caspase-3-dependent regulation of the " sphingomyelin cycle" in Fas-induced apoptosis. Cancer Res. 2004, 64:1000-1007.
21. Laurent G., Jaffrézou J.P. Signaling pathways activated by daunorubicin. Blood 2001, 98:913-924.
22. Bose R., Verheij M., Haimovitz-Friedman A., Scotto K., Fuks Z., Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 1995, 82:405-414.
23. J.P. Jaffrézou, T. Levade, A. Bettaïeb, et al., Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis, EMBO J. 15 (1996) 15 2417-2424.
24. Gamen S., Anel A., Pérez-Galán P., et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp. Cell Res. 2000, 258:223-235.
25. Thayyullathil F., Chathoth S., Hago A., Wernery U., Patel M., Galadari S. Investigation of heat stress response in the camel fibroblast cell line dubca. Ann. NY Acad. Sci. 2008, 1130:376-384.
26. Thayyullathil F., Chathoth S., Shahin A., et al. Protein phosphatase 1 dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. J. Cell Biochem. 2011, 112:1138-1153.
27. Thayyullathil F., Chathoth S., Hago A. Et al. Purification and characterization of a second type of neutral ceramidase from rat brain: A second more hydrophobic form of rat brain ceramidase. Biochim. Biophys. Acta 2011, 1811:242-252.
28. Morgan S.E., Kastan M.B. P53 and ATM: cell cycle, cell death, and cancer. Adv. Cancer Res. 1997, 71:1-25.
29. Lakin N.D., Jackson S.P. Regulation of p53 in response to DNA damage. Oncogene 1999, 18:7644-7655.
30. Shen Y., White E. P53-dependent apoptosis pathways. Adv. Cancer Res. 2001, 82:55-84.
31. el-Deiry W.S. Regulation of p53 downstream genes. Semin. Cancer Biol. 1998, 8:345-357.
32. Meek D.W. Mechanisms of switching on p53: a role for covalent modification?. Oncogene 1999, 18:7666-7675.
33. Kurita-Ochiai T., Amano S., Fukushima K., Ochiai K. Cellular events involved in butyric acid-induced T cell apoptosis. J. Immunol. 2003, 171:3576-3584.
34. Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9:231-241.
35. Liu X., Chua C.C., Gao J., et al. Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H933-H939.
36. Hammond C.L., Madejczyk M.S., Ballatori N. Activation of plasma membrane reduced glutathione transport in death receptor apoptosis of HepG2 cells. Toxicol. Appl. Pharmacol. 2004, 195:12-22.
37. Ghibelli L., Fanelli C., Rotilio G., et al. Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J. 1998, 12:479-486.
38. Franco R., Cidlowski J.A. SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis. J. Biol. Chem. 2006, 281:29542-29557.
39. Modrak D.E., Gold D.V., Goldenberg D.M. Sphingolipid targets in cancer therapy. Mol. Cancer Ther. 2006, 5:200-208.
40. Ogretmen B., Hannun Y.A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 2004, 4:604-616.
41. Erdreich-Epstein A., Tran L.B., Bowman N.N., et al. Ceramide signaling in fenretinide-induced endothelial cell apoptosis. J. Biol. Chem. 2002, 277:49531-49537.