Rescue of cells from apoptosis by inhibition of active GSH extrusion

FASEB Journal

Volumn 12, Issue 6, 1998, Pages 479-486

  Ghibelli, L ^a   Fanelli, C ^a   Rotilio, G ^a   Lafavia, E ^a   Coppola, S ^a   Colussi, C ^a   Civitareale, P ^a   Ciriolo, M R ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Cystathionine; GSH efflux; Methionine; Puromycin

Indexed keywords

CYSTATHIONINE; GLUTATHIONE; METHIONINE; PUROMYCIN;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; HEPATOMA CELL; HUMAN; HUMAN CELL; MONOCYTE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

EID: 0031897274     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.6.479     Document Type: Article

References (37)

1. Wyllie, A. H., Ker, J. F. R., and Currie, A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-273
2. Kerr, J. F. R., and Harmon, B. V. (1991) Apoptosis: The Molecular Basis of Cell Death (Tomei, L. D., and Cope, F. O., eds) pp. 5-29, Cold Spring Harbor Lab. Press, Cold Spring Harbor, N.Y.
3. Wyllie, A. H. (1987) Apoptosis: cell death in tissue regulation. J. Pathol. 153, 313-316
4. Buttke, T. M., and Sandstrom, P. A. (1994) Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7-10
5. Cotter, T. G., Lennon, S. V., Glynn, J. M., and Green, D. R. (1992) Microfilament disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res. 52, 997-1005
6. Dini, L., Coppola, S., Ruzittu, M. T., and Ghibelli, L. (1996) Multiple pathways for apoptotic nuclear fragmentation. Exp. Cell Res. 223, 340-347
7. Kumar, S. (1995) ICE-like proteases in apoptosis. Trends Biochem. Sci. 20, 198-202
8. Lennon, S. V., Martin, S. J., and Cotter, T. G. (1991) Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif. 24, 203-214
9. Nosseri, C., Coppola, S., and Ghibelli, L. (1994) Possible involvement of poly(ADP-ribosyl)polymerase in triggering stress-induced apoptosis. Exp. Cell Res. 212, 367-373
10. Zeng, L., Xia, Y., Garcia, G. E., Hwang, D., and Wilson, C. B. (1995) Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J. Clin. Invest. 95, 1669-1675
11. Zuckerman, S. H., Evans, G. F., and Guturie, L. (1991) Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA. Immunol 73, 460-465
12. Malorni, W., D'Ambrosio, A., Rainaldi, G., Rivabene, R., and Viola, M. (1994) Thiol supplier N-acetylcystein enhances conjugate formation between natural killer cells and K562 or U937 targets but increases the lytic function only against the latter. Immunol. Lett. 43, 209-214
13. Korsmeyer, S. J. (1992) Bcl-2: a repressor of lymphocyte death. Immunol. Today 14, 131-136
14. Hockenbery, D. M., Oltvai, Z. N.,Yin, X. N., Milliman, C. L., and Korsmeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251
15. Shimizu, S., Eguchi, Y., Kosaka, H., Kamiike, W., Matsuda, H., and Tsujimoto, Y. (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature (London) 374, 811-813
16. Jacobson, M. D., Raff, M. C. (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature (London) 374, 814-816
17. Meister, A., and Anderson, M. E. (1983) Glutathione. Annu. Rev. Biochem. 52, 711-760
18. Reed, D. J. (1990) Glutathione: toxicological implication. Annu. Rev. Pharmacol Toxicol. 30, 603-631
19. Aw, T. Y., Ooktens, M., and Kaplowitz, N. (1984) Inhibition of glutathione efflux from isolated rat hepatocytes by methionine. J. Biol. Chem. 259, 9355-9358
20. Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Butler Gralla, E., Seiverstone Valentine, J., Ord, T., and Bredesen, T. E. (1993) Bcl-2 inhibition of neural death: decreased geration of reactive oxygen species. Science 262, 1274-1277
21. Slater, A. F. C., Nobel, C. S. I., Maellaro, E., Bustamante, J., Kimland, M., and Orrenius, S. (1995) Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. J. 306, 771-778
22. Ghibelli, L., Coppola, S., Rotilio, G., Lafavia, E., Maresca, V., and Ciriolo, M. R. (1995) Non-oxidative loss of glutathione in apoptosis via GSH extrusion. Biochem. Biophys. Res. Commun. 216, 313-320
23. Reed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, M. W., and Potter, D. W. (1980) High performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulphide and related thiols and disulphides. Anal. Biochem. 106, 55-62
24. Lowry, O. H., Rosebrough, N. J., Fair, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
25. Iu, S. C., Sun, W. M., Yi, J., Ookthens, M., Sze, G., and Kaplowitz, N. (1996) Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH mammalian cells. J. Clin. Invest. 97, 1488-1496
26. Chow, S. C., Peters, I., and Orrenius, S. (1995) Reevaluation of the role of de novo protein synthesis in rat thymocytes apoptosis. Exp. Cell Res. 216, 149-159
27. 2-induced apoptosis by ADP-ribosylation inhibitors is related to cell blebbing. Exp. Cell Res. 221, 470-477
28. Wright, S. C., Wei, Q. S., Kinder, D. H., and Larrick, J. (1996) Biochemical pathways of apoptosis: nicotinamide adenine di-nucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA. J Exp. Med. 183, 463-471
29. Kaplowitz, N. (1990) Inhibition of GSH efflux from rat liver by methionine effects of GSH synthesis in cells and perfused organ. Am. J. Physiol. 258, G967-G973
30. Beatty, P. W., and Reed, D. J. (1980) Involvement of the cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes. Arch. Biochem. Biophys. 204, 80-87
31. Rouzer, C. A., Scott, W. A., Griffith, O. W., Hamill, A. L., and Cohn, Z. A. (1981) Glutathione metabolism in resting and phagocytizing peritoneal macrophages. J. Biol. Chem. 257, 2002-2008
32. Van den Dobbelsteen, D., Nobel, S., Schlegel, J., Cotgreave, I. A., Orrenius, S., and Slater, A. (1996) Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-fas/APO1 antibody. J. Biol. Chem. 271, 15420-15427
33. Ghibelli, L., Maresca, V., Coppola, S., and Gualandi, G. (1995) Protease inhibitors block apoptosis at intermediate stages: a compared analysis of DNA fragmentation and apoptotic nuclear morphology. FEBS Lett. 377, 9-14
34. Grierson, A. W., Nicholson, R., Talbot, P., Webster, A., and Kemp, G. (1994) The protease of adenovirus serotype 2 requires cysteine residues for both activation and catalysis. J. Gen. Virol. 75, 2761-2764
35. Luthen, R., Niederau, C., and Grendell, J. H. (1995) Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats. Am. J. Physiol. 268, G592-G604
36. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssier, J. L., Petit, P. X., and Kroemer, G. (1995) Reduction in mitochondrial potential constitutes an early and irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181, 1661-1672
37. Macho, A., Hirsch, T., Marzo, I., Marchetti, P., Dallaporta, B., Susi, S. A., Zamzami, N., and Kroemer, G. (1997) Glutathione depletion is an early event and calcium elevation is a late event of thymocyte apoptosis. J. Immunol. 158, 4612-4619