Comparative analysis of enzyme and pathway engineering strategies for 5FC-mediated suicide gene therapy applications

Cancer Gene Therapy

Volumn 18, Issue 8, 2011, Pages 533-542

  Johnson, A J ^a   Ardiani, A ^a   Sanchez Bonilla, M ^a   Black, M E ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

5 fluorocytosine; bystander effect; cytosine deaminase; suicide gene therapy; uracil phosphoribosyltransferase

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; PRODRUG; URACIL PHOSPHORIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CANCER INHIBITION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME PRODRUG THERAPY; ENZYME STABILITY; ESCHERICHIA COLI; FEMALE; GLIOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; SUICIDE GENE THERAPY; THERMOSTABILITY; TREATMENT DURATION; TUMOR XENOGRAFT; WILD TYPE;

ANIMALS; ARTIFICIAL GENE FUSION; CELL LINE, TUMOR; CYTOSINE DEAMINASE; DISEASE MODELS, ANIMAL; FLUCYTOSINE; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GLIOMA; HUMANS; MICE; MICE, NUDE; MUTAGENESIS, SITE-DIRECTED; PRODRUGS; RATS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

BACTERIA (MICROORGANISMS);

EID: 79960563757     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.6     Document Type: Article

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