Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference

Biochemistry

Volumn 43, Issue 28, 2004, Pages 8957-8964

  Mahan, Sheri D ^a   Ireton, Greg C ^b   Stoddard, Barry L ^b   Black, Margaret E ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYMES; GENES; MUTAGENESIS; ONCOLOGY; SUBSTRATES;

CYTOSINE; MUTANTS;

BIOCHEMISTRY;

ALANINE; AMINO ACID; CYTOSINE DEAMINASE; CYTOTOXIN; FLUCYTOSINE; FLUOROURACIL; PRODRUG; PYRIMIDINE DERIVATIVE;

ARTICLE; BACTERIAL GENE; CANCER CELL; CODA GENE; CONFORMATIONAL TRANSITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE TARGETING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUICIDE GENE;

ALANINE; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLIZATION; CYTOSINE; CYTOSINE DEAMINASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUCYTOSINE; GENES, TRANSGENIC, SUICIDE; GENETIC COMPLEMENTATION TEST; MUTAGENESIS, SITE-DIRECTED; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 3142668353     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049720z     Document Type: Article

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