Human neural stem cells transduced with IFN-β and cytosine deaminase genes intensify bystander effect in experimental glioma

Cancer Gene Therapy

Volumn 17, Issue 5, 2010, Pages 299-306

  Ito, S ^a   Natsume, A ^a   Shimato, S ^a   Ohno, M ^a   Kato, T ^a   Chansakul, P ^a   Wakabayashi, T ^a   Kim, S U ^b,c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

Cytosine deaminase; Giloma; Human neural stem cells; Interferon ; Retrovirus

Indexed keywords

BETA INTERFERON; CYTOSINE DEAMINASE; FLUCYTOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BYSTANDER EFFECT; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSDUCTION; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; TUMOR VOLUME; XENOGRAFT;

ANIMALS; BYSTANDER EFFECT; CELL LINE, TUMOR; CYTOSINE DEAMINASE; DISEASE MODELS, ANIMAL; FEMALE; FLUCYTOSINE; GENE THERAPY; GLIOMA; HUMANS; INTERFERON-BETA; MICE; MICE, NUDE;

ANIMALIA;

EID: 77951100891     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2009.80     Document Type: Article

References (23)

1. Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 1993; 71: 2585-2597.
2. Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D et al. Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 2000; 6: 447-450.
3. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000; 97: 12846-12851.
4. Barresi V, Belluardo N, Sipione S, Mudo G, Cattaneo E, Condorelli DF. Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer Gene Ther 2003; 10: 396-402.
5. Shimato S, Natsume A, Takeuchi H, Wakabayashi T, Fujii M, Ito M et al. Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medullo-blastoma. Gene Ther 2007; 14: 1132-1142.
6. Joo KM, Park IH, Shin JY, Jin J, Kang BG, Kim MH et al. Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases. Mol Ther 2009; 17: 570-575.
7. Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC et al. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res 2006; 12: 5550-5556.
8. Aboody KS, Najbauer J, Schmidt NO, Yang W, Wu JK, Zhuge Y et al. Targeting of melanoma brain metastases using engineered neural stem\progenitor cells. Neuro Oncol 2006; 8: 119-126.
9. Yoshida J, Mizuno M, Fujii M, Kajita Y, Nakahara N, Hatano M et al. Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. Hum Gene Ther 2004; 15: 77-86.
10. Wakabayashi T, Natsume A, Hashizume Y, Fujii M, Mizuno M, Yoshida J. A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. J Gene Med 2008; 10: 329-339.
11. Kim SU. Human neural stem cells genetically modified for brain repair in neurological disorders. Neuropathology 2004; 24: 159-171.
12. Borden EC, Lindner D, Dreicer R, Hussein M, Peereboom D. Second-generation interferons for cancer: clinical targets. Semin Cancer Biol 2000; 10: 125-144.
13. Mizuno M, Yoshida J. Effect of human interferon beta gene transfer upon human glioma, transplanted into nude mouse brain, involves induced natural killer cells. Cancer Immunol Immunother 1998; 47: 227-232.
14. Natsume A, Mizuno M, Ryuke Y, Yoshida J. Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse. Gene Ther 1999; 6: 1626-1633.
15. Natsume A, Tsujimura K, Mizuno M, Takahashi T, Yoshida J. IFN-beta gene therapy induces systemic antitumor immunity against malignant glioma. J Neurooncol 2000; 47: 117-124.
16. Yagi K, Hayashi Y, Ishida N, Ohbayashi M, Ohishi N, Mizuno M et al. Interferon-beta endogenously produced by intratumoral injection of cationic liposome-encapsulated gene: cytocidal effect on glioma transplanted into nude mouse brain. Biochem Mol Biol Int 1994; 32: 167-171.
17. Wakabayashi T, Natsume A, Hashizume Y, Fujii M, Mizuno M, Yoshida J. A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. J Gene Med 2008; 10: 329-339.
18. Chiocca EA, Smith KM, McKinney B, Palmer CA, Rosenfeld S, Lillehei K et al. A phase I trial of Ad.hIFN-beta gene therapy for glioma. Mol Ther 2008; 16: 618-626.
19. Schmidt NO, Przylecki W, Yang W, Ziu M, Teng Y, Kim SU et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. Neoplasia 2005; 7: 623-629.
20. Kendall SE, Najbauer J, Johnston HF, Metz MZ, Li S, Bowers M et al. Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling. Stem Cells 2008; 26: 1575-1586.
21. Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU et al. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of inter-feron-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg 2007; 42: 48-53.
22. Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, Trakhtenbrot L et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 2009; 6: e1000029.
23. Takeuchi H, Natsume A, Wakabayashi T, Aoshima C, Shimato S, Ito M et al. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1-and HGF-dependent manner. Neurosci Lett 2007; 426: 69-74.