Kinetic mechanism of uracil phosphoribosyltransferase from Escherichia coli and catalytic importance of the conserved proline in the PRPP binding site

Biochemistry

Volumn 38, Issue 11, 1999, Pages 3327-3334

  Lundegaard, Claus ^a   Jensen, Kaj Frank ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Structural Bioinformatics Advanced Technologies A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

PROLINE; URACIL PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; GENE MUTATION; LIGAND BINDING; MOLECULAR CLONING; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; ESCHERICHIA COLI; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PENTOSYLTRANSFERASES; PHOSPHORIBOSYL PYROPHOSPHATE; PROLINE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; URIDINE MONOPHOSPHATE;

EID: 0033574207     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982279q     Document Type: Article

References (49)

1. Musick, W. D. L. (1981) CRC Crit. Rev. Biochem. 11, 1-34.
2. Jensen, K. F. (1983) in Metabolism of Nucleotides, Nucleosides and Nucleobases in Microorganisms (Munch-Petersen, A., Ed.) pp 1-25, Academic Press, London.
3. Crawford, I., Kornberg, A., and Simms, E. S. (1957) J. Biol. Chem. 193, 1093-1101.
4. Traut, T. W., and Jones, M. E. (1996) Prog. Nucleic Acid Res. Mol. Biol. 53, 1-78.
5. Fast, R., and Sköld, O. (1977) J. Biol. Chem. 252, 7620-7624.
6. Rasmussen, U. B., Mygind, B., and Nygaard, P. (1986) Biochim. Biophys. Acta 881, 268-275.
7. Jensen, K. F., and Mygind, B. (1996) Eur. J. Biochem. 240, 637-645.
8. Molloy, A., and Finch, L. R. (1969) FEBS Lett. 5, 211-213.
9. Jensen, H. K., Mikkelsen, N., and Neuhard, J. (1997) Protein Expression Purif. 10, 356-364.
10. Linde, L., and Jensen, K. F. (1996) Biochim. Biophys. Acta 1296, 16-22.
11. Natalini, P., Rugguirerri, S., Santarelli, I., Vita, A., and Magni, G. (1979) J. Biol. Chem. 254, 1558-1563.
12. Asai, T., Lee, C. S., Chandler, A., and O'Sullivan, W. J. (1990) Comput. Biochem. Physiol. 95B, 159-163.
13. Dai, Y.-P., Lee, C. S., and O'Sullivan, W. J. (1995) Int. J. Parasitol. 25, 207-214.
14. Jyssum, S., and Jyssum, K. (1979) J. Bacteriol. 138, 320-323.
15. Alloush, H. M., and Kerridge, D. (1994) Mvcopathologia 125, 129-141.
16. Mitchell, A., and Finch, L. R. (1979) J. Bacteriol. 137, 1073-1080.
17. Kern, L., de Montigny, J., Jund, R., and Lacroute, F. (1990) Gene 88, 149-157.
18. Kern, L., de Montigny, J., Lacroute, F., and Jund, R. (1991) Curr. Genet. 19, 333-337.
19. Martinussen, J., Andersen, P. S., and Hammer, K. (1994) J. Bacteriol. 176, 1514-1516.
20. Andersen, P. S., Martinussen, J., and Hammer, K. (1996) J. Bacteriol. 178, 5005-5012.
21. Xu, Y., Eads, J., Sacchettini, J. C., and Grubmeyer, C. (1997) Biochemists 36, 3700-3712.
22. Tao, W., Grubmeyer, C., and Blanchard, J. S. (1996) Biochemistry 35, 14-21.
23. Bhatia, M. B., Vititsky, A., and Grubmeyer, C. (1990) Biochemistry 29, 10480-10487.
24. Gross, J. W., Rajavel, M., and Grubmeyer, C. (1998) Biochemistry 37, 4189-4199.
25. Eads, J. C., Ozturk, D., Wexler, T. B., Grubmeyer, C., and Sacchettini, J. C. (1997) Structure 5, 47-58.
26. Hershey, H. V., and Taylor, M. W. (1986) Gene 43, 287-293.
27. Hove-Jensen, B., Harlow, K. V., King, C. J., and Switzer, R. L. (1986) J. Biol. Chem. 261, 6765-6771.
28. Willemoës, M., Nilsson, D., and Hove-Jensen, B. (1996) Biochemistry 35, 8181-8186.
29. Ozturk, D., Dorfman, R. H., Scapin, G., Sacchettini, J. C., and Grubmeyer, C. (1995) Biochemistry 34, 10764-10770.
30. Eads, J. C., Scapin, G., Xu, Y., Grubmeyer, C., and Sacchettini, J. C. (1994) Cell 78, 325-334.
31. Scapin, G., Ozturk, D. H., Gruibmeyer, C., and Sacchettini, J. C. (1995) Biochemistry 34, 10744-10754.
32. Krahn, J. M., Kim, J. H., Burns, M. R., Parry, R. J., Zalkin, H., and Smith, J. L. (1997) Biochemistry 36, 11061-11068.
33. Led, J. J., Switon, W. K., and Jensen, K. F. (1983) Eur. J. Biochem. 136, 469-479.
34. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene 77, 51-59.
35. Munch-Petersen, A., Mygind, B., Nicholaisen, A., and Pihl, N. J. (1979) J. Biol. Chem. 254, 3730-3737.
36. Miller, J. H. (1972) Experiments in molecular genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
37. Jensen, K. F., Houlberg, U., and Nygaard, P. (1979) Anal. Biochem. 98, 254-263.
38. Ormö, M., and Sjöberg, B.-M. (1990) Anal. Biochem. 189, 138-141.
39. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
40. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 104-137.
41. Tavares, A., Lee, C. S., and O'Sullivan, W. J. (1987) Biochim. Biophys. Acta 913, 279-284.
42. Traut, T. H., and Jones, M. E. (1977) J. Biol. Chem. 252, 8374-8381.
43. Victor, J., Greenberg, L. B., and Sloan, D. L. (1979) J. Biol. Chem. 254, 2647-2655.
44. Lieberman, I., and Kornberg, A. (1953) Biochim. Biophys. Acta 12, 223-234.
45. Yuang, L., Wu, C.-S. C., Craig, S. P., III, Liu, A. F., and Wang, C. C. (1993) Biochim. Biophys. Acta 1162, 10-16.
46. Wang, G., Lundegaard, C., Jensen, K. F., and Grubmeyer, C. (1999) Biochemistry 38, 275-283.
47. Grubmeyer, C., and Wang, G. (1998) Paths Pyrimidines 6, 1-11.
48. Scapin, G., Grubmeyer, C., and Sacchettini, J. C. (1994) Biochemistry 33, 1287-1294.
49. Schumacher, M. A., Carter, D., Scott, D. M., Roos, D. S., Ullman, B., and Brennan, R. G. (1998) EMBO J. 17, 3219-3232.