Organ-derived dendritic cells have differential effects on alloreactive T cells

Blood

Volumn 111, Issue 5, 2008, Pages 2929-2940

  Kim, Theo D ^a   Terwey, Theis H ^a   Zakrzewski, Johannes L ^a   Suh, David ^a   Kochman, Adam A ^a   Chen, Megan E ^a   King, Chris G ^a   Borsotti, Chiara ^a   Grubin, Jeremy ^a   Smith, Odette M ^a   Heller, Glenn ^a   Liu, Chen ^b   Murphy, George F ^c   Alpdogan, Onder ^a   Van Den Brink, Marcel R M ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GRAFT VERSUS HOST REACTION; HISTOINCOMPATIBILITY; INTESTINE LYMPH; LIVER; MAJOR HISTOCOMPATIBILITY COMPLEX; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; SPLEEN; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; BAGG ALBINO MOUSE; C57BL MOUSE; CELL PROLIFERATION; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHENOTYPE; SURVIVAL RATE; UPREGULATION;

ALLOANTIGEN; HOMING RECEPTOR; INTEGRIN; INTEGRIN ALPHA4BETA7; LIGAND; LIPOPOLYSACCHARIDE; SELECTIN; UNCLASSIFIED DRUG;

ANIMALS; CELL PROLIFERATION; DENDRITIC CELLS; GENE EXPRESSION PROFILING; GRAFT VS HOST DISEASE; HUMANS; INTEGRINS; ISOANTIGENS; LIGANDS; LIPOPOLYSACCHARIDES; LIVER; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SPECIFICITY; PHENOTYPE; RECEPTORS, LYMPHOCYTE HOMING; SELECTINS; SURVIVAL RATE; T-LYMPHOCYTES; UP-REGULATION;

EID: 41949131652     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-06-096602     Document Type: Article

References (62)

1. Ferrara JL, Deeg HJ, Burakoff SJ. Graft-vs-host disease. 2nd ed. New York, NY: Marcel Dekker; 1997.
2. Ferrara JL, Deeg HJ. Graft-versus-host disease. N Engl J Med. 1991;324:667-674.
3. Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol. 2007;7:340-352.
4. Ferrara JL, Reddy P. Pathophysiology of graft- versus-host disease. Semin Hematol. 2006;43:3-10.
5. Hill GR, Ferrara JL. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95:2754-2759.
6. Shlomchik WD. Antigen presentation in graft-vs-host disease. Exp Hematol. 2003;31:1187-1197.
7. Duffner UA, Maeda Y Cooke KR, et al. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004;172: 7393-7398.
8. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
9. Zhang Y, Louboutin JP, Zhu J, RiveraAJ, Emerson SG. Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease. J Clin Invest. 2002; 109:1335-1344.
10. Chakraverty R, Sykes M. The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood. 2007; 110:9-17.
11. Zhang Y, Shlomchik WD, Joe G, et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J Immunol. 2002;169:7111-7118.
12. Merad M, Hoffmann P, Ranheim E, et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med. 2004;10:510-517.
13. Matte CC, Liu J, Cormier J, et al. Donor APCs are required for maximal GVHD but not for GVL. Nat Med. 2004;10:987-992.
14. Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood. 2005;105:2227-2234.
15. Jones SC, Murphy GF, Friedman TM, Korngold R. Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model. J Clin Invest. 2003;112:1880-1886.
16. Teshima T, Ordemann R, Reddy P, et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575-581.
17. Dudda JC, Martin SF. Tissue targeting of T cells by DCs and microenvironments. Trends Immunol. 2004;25:417-421.
18. Mora JR, von Andrian UH. T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol. 2006;27:235-243.
19. Agace WW. Tissue-tropic effector T cells: generation and targeting opportunities. Nat Rev Immunol. 2006;6:682-692.
20. Johansson-Lindbom B, Svensson M, Wurbel MA, Malissen B, Marquez G, Agace W. Selective generation of gut tropic Tcells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med. 2003;198: 963-969.
21. Stagg AJ, Kamm MA, Knight SC. Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol. 2002;32: 1445-1454.
22. Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature. 2003;424:88-93.
23. Mora JR, Cheng G, Picarella D, Briskin M, Buchanan N, von Andrian UH. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med. 2005;201:303-316.
24. Dudda JC, Lembo A, Bachtanian E, et al. Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol. 2005;35:1056-1065.
25. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21:527- 538.
26. Sigmundsdottir H, Pan J, Debes GF, et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol. 2007;8:285-293.
27. Mora JR, Iwata M, Eksteen B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006;314:1157-1160.
28. Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol. 2005;6:1182-1190.
29. Sackstein R. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2006;12:2-8.
30. Wysocki CA, Panoskaltsis-Mortari A, Blazar BR, Serody JS. Leukocyte migration and graft-versus- host disease. Blood. 2005;105:4191-4199.
31. Terwey TH, Kim TD, Kochman AA, et al. CCR2 is required for CD8-induced graft-versus-host disease. Blood. 2005;106:3322-3330.
32. National Center for Biotechnology Information. Gene Expression Omnibus (GEO). http://ncbi.nlm.nib.gov/geo/. Accessed January 2008.
33. Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I, the roles of minor H antigens and endotoxin. Blood. 1996;88: 3230-3239.
34. Ferrara J, Guillen FJ. Sleckman B, Burakoff SJ, Murphy GF. Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease. J Invest Dermatol. 1986;86: 371-375.
35. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood. 1997;90:3204-3213.
36. Campbell DJ, Butcher EC. Rapid acquisition of tissue-specific homing phenotypes by CD4( + ) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med. 2002;195:135-141.
37. Beilhack A, Schulz S, Baker J, et al. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood. 2005;106:1113-1122.
38. Shi GP, Villadangos JA, Dranoff G, et al. Cathep- sin S required for normal MHC class II peptide loading and germinal center development. Immunity. 1999;10:197-206.
39. Sato T, Habtezion A, Beilhack A, Schulz S, Butcher E, Thorlacius H. Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host disease. J Hepatol. 2006;44:1132-1140.
40. National Center for Biotechnology Information. GenBank. http://ncbi.nlm.nih.gov/GenBank/. Accessed January 2008.
41. Petrovic A, Alpdogan O. Willis LM, et al. LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood. 2004;103:1542-1547.
42. Dudda JC, Simon JG, Martin S. Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets. J Immunol. 2004;172:857-863.
43. Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol. 2003;3:51-62.
44. Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut. 2003;52:307-314.
45. Thomson AW, Lu L. Are dendritic cells the key to liver transplant tolerance? Immunol Today. 1999; 20:27-32.
46. Pillarisetty VG, Shah AB, Miller G, Bleier Jl, De-Matteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol. 2004;172:1009-1017.
47. De Creus A, Abe M, Lau AH, Hackstein H, Raimondi G, Thomson AW. Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol. 2005;174:2037-2045.
48. Sato T, Thorlacius H, Butcher E. Lymphocyte Homing to the Liver. Curr Med Chem - Anti-Inflammatory Anti-Allergy Agents. 2004;3:331-339.
49. Sato T, Thorlacius H, Johnston B, et al. Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J Immunol. 2005;174: 277-283.
50. Ichiba T. Teshima T. Kuick R, et al. Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays. Blood. 2003;102:763-771.
51. Sugerman PB, Faber SB, Willis LM, et al. Kinetics of gene expression in murine cutaneous graft-versus-host disease. Am J Pathol. 2004; 164: 2189-2202.
52. Taylor S, Herrington S, Prime W, Rudland PS, Barraclough R. S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes. Br J Gancer. 2002;86:409-416.
53. Gattinoni L, Klebanoff CA, Palmer DC, et al. Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest. 2005;115:1616-1626.
54. Duffner U, Lu B, Hildebrandt GC, et al. Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol. 2003;31:897-902.
55. El-Asady R, Yuan R, Liu K, et al. TGF-{beta}-de- pendent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J Exp Med. 2005;201:1647-1657.
56. Dutt S, Ermann J, Tseng D, et al. L-selectin and beta7 integrin on donor GD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood. 2005;106:4009-4015.
57. Waldman E, Lu SX; Hubbard VM, et al. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 2006;107: 1703-1711.
58. Ghakraverty R, Cote D, Buchli J, et al. An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med. 2006;203:2021-2031.
59. Panoskaltsis-Mortari A, Price A, Hermanson JR. et al. In vivo imaging of graft-versus-host-disease in mice. Blood. 2004;103:3590-3598.
60. Murai M, Yoneyama H, Ezaki T, et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003;4:154-160.
61. Welniak LA, Kuprash DV. Tumanov AV, et al. Peyer patches are not required for acute graft- versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation. Blood. 2006;107:410-412.
62. Beilhack A, Schulz S, Baker J, et al. Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood. Pre- published on November 7, 2007, as DOI 10.1182/blood-2007-09-112789.