Failure to induce organ-specific autoimmunity by breaking of tolerance: Importance of the microenvironment

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2395-2406

  Limmer, Andreas ^a   Sacher, Torsten ^a   Alferink, Judith ^a   Kretschmar, Marianne ^b   Schönrich, Günter ^b   Nichterlein, Thomas ^b   Arnold, Bernd ^a   Hämmerling, Günter J ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autoimmunity; Breaking of tolerance; Microenvironment

Indexed keywords

INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE; TISSUE INJURY; TRANSGENIC MOUSE;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; GRAFT REJECTION; H-2 ANTIGENS; HEPATITIS, ANIMAL; INTERLEUKIN-2; LISTERIA INFECTIONS; LIVER; LYMPHOCYTE ACTIVATION; MAST-CELL SARCOMA; MICE; MICE, INBRED CBA; MICE, INBRED DBA; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; SELF TOLERANCE; T-LYMPHOCYTES;

EID: 0031879057     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2395::AID-IMMU2395>3.0.CO;2-D     Document Type: Article

References (51)

1. Kruisbeek, A. M. and Amsen, D., Mechanisms underlying T cell tolerance. Curr. Opin. Immunol. 1996. 8: 233-244.
2. Miller, J. F. A. P. and Flavell, R. A., T cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance. Curr. Op. Immunol. 1994. 6: 892-899.
3. Hämmerling, G. J., Schönrich, G., Ferber, I. and Arnold, B., Peripheral tolerance as a multi-step mechanism. Immunol. Rev. 1993. 133: 93-104.
4. Webb, S., Morris, C. and Sprent, J., Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 1990. 63: 1249-1256.
5. Fields, L. E. and Loh, D. Y., Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice. Proc. Natl. Acad. Sci. USA 1992. 89: 5730-5734.
6. Schönrich, G., Kalinke, U., Momburg, F., Malissen, M., Schmitt-Verhulst, A.-M., Malissen, B., Hämmerling, G. J. and Arnold, B., Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 1991. 65: 293-304.
7. Schönrich, G., Momburg, F., Malissen, M., Schmitt-Verhulst, A.-M., Malissen, B., Hämmerling, G. J. and Arnold, B., Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen. Int. Immunol. 1992. 4: 581-590.
8. Ferber, I, Schönrich, G., Schenkel, J., Mellor, A. L., Hämmerling, G. J. and Arnold, B., Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science 1994. 263: 674-676.
9. Streilein, J. W., Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transpl. Proceed. 1996. 28: 2066-2070.
10. Burkly, L. C., Lo, D. and Flavell, R. A., Tolerance in transgenic mice expressing MHC molecules extrathymically on pancreatic cells. Science 1990. 248: 1364-1368.
11. Ohashi, P. S., Oehen, S., Buerki, K., Pircher, H., Ohashi, C. T., Odermatt, B., Malissen, B., Zinkernagel, R. M. and Hengartner, H., Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991. 65: 305-317.
12. Wekerle, H., Bradl, M., Linington, C., Kaab, G. and Kojima, K., The shaping of the brain-specific T-lymphocyte repertoire in the thymus. Immunol. Rev. 1996. 149: 231-243.
13. Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J. and Lewicki, H., Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991. 65: 319-331.
14. Ohashi, P. S., Oehen, S., Aichele, P., Pircher, H., Odermatt, B., Herrera, P., Higuchi, Y., Buerki, K., Hengartner, H. and Zinkernagel, R. M., Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-α. J. Immunol. 1993. 150: 5185-5194.
15. Picarella, O. E., Kratz, H., Li, C. B., Ruddle, N. H. and Flavell, R. A., Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J. Immunol. 1993. 150: 4136-4150.
16. Sarvetnick, N., Shizuru, J., Liggitt, D., Martin, L., Mclntyre, B., Gregory, A., Parslow, T. and Stewart, T., Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 1990. 346: 844-847.
17. Guerder, S., Meyerhoff, F. and Flavell, R. A., The role of the T cell costimulator B7-1 in autoimmunity and induction and maintenance of tolerance to peripheral antigen. Immunity 1994. 1: 155-166.
18. Von Herrath, M. G., Guerder, S., Lewicki, H. H., Flavell, R. H. and Oldstone, M. B. A., Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity 1995. 3: 727-738.
19. Sinha, A. A., Lopez, M. T. and McDevitt, H. O., Autoimmune disease: the failure of self tolerance. Science 1990. 248: 1380-1388.
20. Gianani, R. and Sarvetnick, N., Viruses, cytokines, antigens, and autoimmunity. Proc. Natl. Acad. Sci. USA 1996. 93: 2257-2259.
21. Krawitt, E. L., Autoimmune hepatitis. N. Engl. J. Meed. 1996. 334: 897-903.
22. Oldstone, M. B. A., Molecular mimicry and autoimmune disease. Cell 1987. 50: 819-820.
23. Wucherpfennig, K. W. and Strominger, J. L., Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995. 80: 695-705.
24. Vaughan, J. H., Infection and autoimmunity. Curr. Opin: Immunol. 1989. 1: 708-717.
25. Pak, C. Y., Eun, H. M., McArthur, R. G. and Yoon, J. W., Association of cytomegalovirus infection with autoimmune type 1 diabetes. Lancet. 1988. 2: 1-4.
26. Robertson, D. A. F., Zhang, S. L., Guy, E. C. and Wright, R., Persistent measles virus genome in autoimmune chronic active hepatitis. Lancet. 1987. 2: 9-11.
27. Alferink, J., Schittek, B., Schönrich, G., Hämmerling, G. J. and Arnold, B., Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol. 1995. 7: 331-336.
28. Krull, M., Most, R., Hippenstiel, S., Domann, E., Chakraborty, T. and Suttorp, N., Listeria monocytogenes potently induces upregulation of endothelial adhesion molecules and neutrophil adhesion to cultured human endothelial cells. J. Immunol. 1997. 159: 1970-1976.
29. Boury, N. M. and Czuprynski, C. J., Listeria monocytogenes infection increases neutrophil adhesion and damage to a murine hepatocyte cell line in vitro. Immunol. Lett. 1995. 46: 111-116.
30. Beverly, B., Kang, S. M., Lenardo, M. J. and Schwartz, R. H., Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 1992. 4: 661-671.
31. Tafuri, A., Alferink, J., Möller, P., Hämmerling, G. J. and Arnold, B., T cell awareness of paternal alloantigens during pregnancy. Science 1995. 270: 630-633.
32. Jacobsen, K., Kravitz, J., Kincade, P. W. and Osmond, D. G., Adhesion receptors on bone marrow stromal cells: In vivo expression of vascular adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and γ-irradiated mice. Blood 1996. 87: 73-82.
33. Shirota, T. and Tavassoli, M., Alterations of bone marrow sinus endothelium induced by ionizing radiation: Implications in the homing of i.v. transplanted marrow cells. Blood Cells 1992. 18: 197-214.
34. Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L. and Deeq, H. J., Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 1995. 31: 1319-1339.
35. Raetz, C. R. H., Biochemistry of endotoxins. Annu. Rev. Biochem. 1990. 59: 129-170.
36. Röcken, M., Urban, J. F. and Shevach, E. M., Infection breaks tolerance. Nature 1992. 359: 79-82.
37. Butcher, E. C. and Picker, L. J., Lymphocyte homing and homeostasis. Science 1996. 272: 60-66.
38. Ando, K., Guidotti, L. G., Cerny, A., Ishikawa, T. and Chisari, F. V., CTL access to tissue antigen is restricted in vivo. J. Immunol. 1994. 153: 482-488.
39. Morita, M., Watanabe, Y. and Akaike, T., Inflammatory cytokines upregulate intercellular adhesion molecule-1 expression on primary cultured mouse hepatocytes and T lymphocyte adhesion. Hepatology 1994. 19: 426-431.
40. Unanue, E. R., Studies in listeriosis show the strong symbiosis between the innate cellular system and the T cell response. Immunol. Rev. 1997. 158: 11-25.
41. Van Oosten, M., Van de Bilt, E., de Vries, H. E., van Berkel, T. J. C. and Kuiper, J., Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. Hepatology 1995. 22: 1538-1546.
42. Soldevila, G., Geiger, T. and Flavell, R. A., Breaking immunologie ignorance to an antigenic peptide of simian virus 40 large T antigen. J. Immunol. 1995. 155: 5590-5600.
43. Schirmbeck, R., Bohm, W., Melber, K. and Reimann, J., Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation. J. Immunol. 1995. 155: 4676-4684.
44. Bevan, M. J., Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med. 1995. 182: 639-641.
45. + T cells. J. Exp. Med. 1997. 186: 239-245.
46. b in the liver. Eur. J. Immunol. 1995. 25: 1932-1942.
47. Heath, W. R., Allison, J., Hoffmann, M. W., Schönrich, G., Hämmerling, G. J., Arnold, B. and Miller, J. F. A. P., Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature. 1992. 359: 547-549.
48. André, I., Gonzalez, A., Katz, J., Benoist, C. and Mathis, D., Checkpoints in the progression of autoimmune disease: Lessons from diabetes models. Proc. Natl. Acad. Sci. USA 1996. 93: 2260-2263.
49. Brabb, T., Goldrath, A. W., von Dassow, P., Paez, A., Liggitt, H. D. and Govermann, J., Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis. J. Immunol. 1997. 159: 497-507.
50. Sambrook, J., Fritsch, E. F. and Maniatis, T. (Eds) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1989. 16.30-16.36.
51. b-specific cytotoxic T cell clone detect several clone-specific molecules. J. Immunol. 1986. 136: 937-1944.